Patents by Inventor Kurt R. Klimpel

Kurt R. Klimpel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anthrax toxin fusion proteins and related methods
    Patent number: 5677274
    Abstract: The present invention provides a nucleic acid encoding a fusion protein comprising a nucleotide sequence encoding the anthrax protective antigen (PA) binding domain of the native anthrax lethal factor (LF) protein and a nucleotide sequence encoding an activity inducing domain of a second protein. Also provided is a nucleic acid encoding a fusion protein comprising a nucleotide sequence encoding the translocation domain and LF binding domain of the native anthrax PA protein and a nucleotide sequence encoding a ligand domain which specifically binds a cellular target. Proteins encoded by the nucleic acid of the invention, vectors comprising the nucleic acids and hosts capable of expressing the protein encoded by the nucleic acids are also provided. A composition comprising the PA binding domain of the native LF protein chemically attached to a non-LF activity inducing moiety is further provided. A method for delivering an activity to a cell is provided.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: October 14, 1997
    Assignee: The Government of the United States as represented by the Secretary of the Department of Health and Human Services
    Inventors: Stephen H. Leppla, Kurt R. Klimpel, Naveen Arora, Yogendra Singh, Peter J. Nichols
  • Anthrax toxin fusion proteins, nucleic acid encoding same
    Patent number: 5591631
    Abstract: The present invention provides a nucleic acid encoding a fusion protein, comprising a nucleotide sequence encoding the protective antigen (PA) binding domain of the native lethal factor (LF) protein and a nucleotide sequence encoding an activity inducing domain of a second protein. Also provided is a nucleic acid encoding a fusion protein, comprising a nucleotide sequence encoding the translocation domain and LF binding domain of the native PA protein and a nucleotide sequence encoding a ligand domain which specifically binds a cellular target. Proteins encoded by the nucleic acid of the invention, vectors comprising the nucleic acids and hosts capable of expressing the protein encoded by the nucleic acids are also provided. A composition comprising the PA binding domain of the native LF protein chemically attached to a non-LF activity inducing moiety is further provided. A method for delivering an activity to a cell is provided.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: January 7, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Stephen H. Leppla, Kurt R. Klimpel, Naveen Arora, Yogendra Singh, Peter J. Nicholls