Abstract: Disclosed herein are thiocolchicine and colchicine analogs and derivatives suitable for use as a muscle relaxant, an anti-inflammatory agent, an anti-gout agent, an anti-proliferative agent, or an anti-cancer agent; methods of making the compounds, and compositions comprising the compounds.

Abstract: Disclosed herein is a method of using colchicine. In one embodiment, the method comprises administering to a patient colchicine and a substrate of cytochrome P450 1A2 and monitoring the patient during administration of colchicine and the substrate for an adverse event. Also disclosed are articles of manufacture comprising a container containing a dosage form of colchicine and a method of manufacturing a colchicine product.

Abstract: The present invention provides various amorphous forms of the compound metaxalone (I), such as solid amorphous metaxalone and amorphous dispersions comprising metaxalone. The present invention further provides pharmaceutical compositions comprising these amorphous forms, and methods of their preparation. The present invention additionally provides methods of treating painful conditions (e.g., such as painful musculoskeletal conditions) comprising administering a therapeutically effective amount of any one of these amorphous forms to a subject in need thereof.

Abstract: Disclosed are new quinine sulfate polymorphs, methods of making the polymorphs as well as formulations prepared therefrom and uses thereof.

Abstract: Active agent compositions comprising active agent particles having an effective average particle size of less than 2000 nm, wherein the compositions comprise a particle sequestrant are disclosed. Compositions having an effective average particle size of less than 2000 nm, wherein the compositions comprise no added surfactants, phospholipids, or combinations thereof, are also disclosed.

Abstract: Disclosed herein is a method of using quinine. The method comprises informing a user that quinine does not induce the activity of a cytochrome p450 isozyme.

Abstract: Disclosed herein is a method of using quinine. In one embodiment, the method comprises obtaining quinine from a container associated with published material providing information that quinine affects the activity of a cytochrome p450 isozyme. In another embodiment, the method comprises informing a user that quinine affects the activity of a cytochrome p450 isozyme. Also included are articles of manufacture comprising a container containing a dosage form of quinine, wherein the container is associated with published material informing that quinine affects activity of a cytochrome p450 isozyme. Also disclosed are a method of treatment and a method of manufacturing a quinine product.

Abstract: A method for producing sodium bicarbonate from a nahcolite deposit comprising injecting water or other aqueous solution at a temperature of at least 250° F. into the deposit, dissolving sodium bicarbonate in the hot water to form a production solution and subjecting the production solution to multiple stages of crystallization. The sodium bicarbonate crystals may be dewatered and dried to form a commercial sodium bicarbonate product.

Abstract: A method for producing sodium bicarbonate from a nahcolite deposit comprising injecting water or other aqueous solution at a temperature of at least 250° F. into the deposit, dissolving sodium bicarbonate in the hot water to form a production solution and subjecting the production solution to multiple stages of crystallization. The sodium bicarbonate crystals may be dewatered and dried to form a commercial sodium bicarbonate product.

Abstract: The present invention relates to compounds having utility as surfactants which are derived from intermediates produced in petroleum biodesulfurization processes. The compounds of the invention include acyloxybiphenylsulfinates, acyloxybiphenylsulfonates, alkyl sulfinatobiphenyl ethers and alkyl sulfonatobiphenyl ethers. The invention also provides methods of producing these compounds.