Abstract: The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

Abstract: A method for removing a predetermined amount of material from the inner surface of a circular article which deviates from a true circular configuration. The outer surface of the article is touch probed to determine its true location in space, and the data are stored in a computer memory. These data are then compared to engineering design data to establish the location of the surface to which material removal is desired. A control computer compares the measured data with the design data, and sends commands to the machine control system, causing the machine to remove the excess material down to the desired dimension. Any deviations from circular are compensated for by moving the article radially relative to the cutting tool as the article moves circumferentially relative to the cutting tool.

Abstract: A buffing guide includes a mating surface, a first guide surface, a second guide surface and means for engaging an airfoil root. The buffing guide directs a buffing wheel into precise contact with a root edge at a point where selective contouring is desired, with sustained contact providing a smooth radiused surface while avoiding the detrimental effects of grinding or milling operations.