Abstract: A drug delivery device (100) for delivering an amount of medicament comprising a housing and a medicament reservoir (135) with a piston (136). The device further comprises a ratchet mechanism comprising a first and a second set of movable and stationary ratchet members (281, 381, 481, 165.1, 365.1) adapted to provide a first and a second plurality of periodic audible signals, during the expelling of medicament. The ratchet mechanism is further adapted for generating the first and second plurality of periodic signals out-of-phase, whereby each of the signals are distinguishable by a user. The ratchet mechanism further comprises means to provide a radial force to counteract influence from radial play, which otherwise may generate variation in the frequency.

Abstract: The invention relates to an injection device comprising an End-of-Content mechanism. The End-of-Content mechanism comprises a piston rod (10) being driven forward by a rotatable piston rod guide (20), a driver (50) attached to a dose setting tube (30) and an End-of-Content tube (40). The End-of-Content tube is moved axially forward during dose setting a distance which correlates to the size of the dose being set. When the accumulated set and ejected dose equals the injectable amount initially available in the cartridge (3), the End-of-Content tube engages a lock mechanism provided in the piston rod guide and the driver engages a stop surface on the End-of-Content tube. Once the End-of-Content mechanism is locked, no further dose can be set and the piston rod guide cannot be rotated. In order to provide a proper engagement between the piston rod guide and the driver, the End-of-Content mechanism is released during dose expelling.

Abstract: The invention relates to a torsion spring driven injection device for delivering set doses of a liquid drug wherein a torsion spring is strained by rotation of a rotatable dose setting structure and released by proximal movement of a piston rod driver. The dose setting structure is coupled to a drive element which is rotated during dose setting and which drive element is released during dosing to thereby rotate the piston rod driver. The piston rod driver is further coupled to the piston rod to generate a rotation and thus forward movement of the piston rod. The drive element and the piston rod driver are coupled to each other by a toothed engagement which is functional both during dose setting and during dose expelling.

Abstract: The invention relates to an injection system or a needle assembly in which a needle cannula secured to an injection device is shielded by a axially movable needle shield. Should the needle cannula be exposed to a force above a predetermined value e.g. if a user drops the injection device onto a hard surface, a locking mechanism will automatically lock and block further movement of the axially movable needle shield and thus render the injection device unusable.

Abstract: The invention relates to a prefilled injection pen for apportioning multiple set doses of a liquid drug. The injection pen comprises a housing assembly with a removable cap rotatable coupled to the housing assembly such that the user has to rotate the removable cap upon mounting and dismounting the removable cap. Rotation of the removable cap initiates a process in which the proximal end of a needle cannula is first inserted into a cartridge permanently embedded in the housing assembly and thereafter moves the cartridge proximally to thereby pump a predetermined amount of the preservative containing liquid drug from the cartridge and into a cleaning chamber carried by an axially movable shield. The needle cannula is mounted in a needle hub which is arranged to follow rotation of the removable cap and guided helically in relation to the housing assembly such that the needle hub is moved proximally upon rotation of the removable cap.

Abstract: The invention relates to an injection device comprising an End-of-Content mechanism. The End-of-Content mechanism comprises a piston rod (10) being driven forward by a rotatable piston rod guide (20), a driver (50) attached to a dose setting tube (30) and an End-of-Content tube (40). The End-of-Content tube is moved axially forward during dose setting a distance which correlates to the size of the dose being set. When the accumulated set and ejected dose equals the injectable amount initially available in the cartridge (3), the End-of-Content tube engages a lock mechanism provided in the piston rod guide and the driver engages a stop surface on the End-of-Content tube. Once the End-of-Content mechanism is locked, no further dose can be set and the piston rod guide cannot be rotated. In order to provide a proper engagement between the piston rod guide and the driver, the End-of-Content mechanism is released during dose expelling.

Abstract: The invention relates to a prefilled injection pen for apportioning multiple set doses of a liquid drug. The injection pen comprises a housing assembly with a removable cap rotatable coupled to the housing assembly such that the user has to rotate the removable cap upon mounting and dismounting the removable cap. Rotation of the removable cap initiates a process in which the proximal end of a needle cannula is first inserted into a cartridge permanently embedded in the housing assembly and thereafter moves the cartridge proximally to thereby pump a predetermined amount of the preservative containing liquid drug from the cartridge and into a cleaning chamber carried by an axially movable shield. The needle cannula is mounted in a needle hub which is arranged to follow rotation of the removable cap and guided helically in relation to the housing assembly such that the needle hub is moved proximally upon rotation of the removable cap.

Abstract: The invention relates to an injection system or a needle assembly in which a needle cannula secured to an injection device is shielded by a axially movable needle shield. Should the needle cannula be exposed to a force above a predetermined value e.g. if a user drops the injection device onto a hard surface, a locking mechanism will automatically lock and block further movement of the axially movable needle shield and thus render the injection device unusable.

Abstract: The invention relates to a device for dispensing a mist of an ophthalmic fluid, the device comprising a discharge opening for said mist, a mixing chamber communicating with a discharge opening, an air chamber, a first drive operable to expel air from the air chamber, a fluid chamber for holding a first volume of the liquid and communicating with the mixing chamber, a dosing chamber for containing a second volume of the liquid corresponding to a plurality of the doses, preferably to two doses, of the liquid, the dosing chamber communicating with or configured for communicating with a supply of the liquid, such as a collapsible liquid container or a liquid container having a movable bottom, and with the fluid chamber, a second drive operable to supply the second volume of the liquid from the supply to the dosing chamber and for emptying the dosing chamber by repetitive delivery of a single dose of the plurality of doses of the liquid contained therein to the fluid chamber, the air chamber communicating with the

Abstract: The methods serves for activating an electric motor of a metering pump with which the fluid quantity (Vnom) to be delivered is set by an external impulse trigger, wherein a predetermined delivery quantity (Vnom) is allocated to each impulse (t). The control detects the temporal interval (?t) of the two last-received impulses and activates the electric motor such that the fluid quantity to be delivered, taking the previously evaluated interval as a basis, is distributed over the subsequent impulse interval.

Abstract: The methods serves for activating an electric motor of a metering pump with which the fluid quantity (Vnom) to be delivered is set by an external impulse trigger, wherein a predetermined delivery quantity (Vnom) is allocated to each impulse (t). The control detects the temporal interval (&Dgr;t) of the two last-received impulses and activates the electric motor such that the fluid quantity to be delivered, taking the previously evaluated interval as a basis, is distributed over the subsequent impulse interval.