Patents by Inventor Kurt Stach, deceased
Kurt Stach, deceased has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4243807Abstract: 4-Phenoxymethyl-piperidines of the formula ##STR1## wherein R is hydrogen, halogen, nitro, lower alkyl or lower alkoxy, in the form of the free base or an acid addition salt, are provided and they are useful as intermediates in the production of anti-hypertensive agents through condensation with (a) propyl chloride and then with an adenine, or (b) a propyl indole.Type: GrantFiled: November 1, 1976Date of Patent: January 6, 1981Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Max Thiel, Kurt Stach, deceased, by Werner Plattner, administrator
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Patent number: 4238506Abstract: Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, andR is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.Type: GrantFiled: June 29, 1978Date of Patent: December 9, 1980Assignee: Boehringer Mannheim GmbHInventors: Kurt Stach, deceased, Elmar Bosies, Ruth Heerdt, Hans-Frieder Kuhnle, Felix H. Schmidt
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Patent number: 4229464Abstract: New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, andR.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen and the pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.Type: GrantFiled: September 18, 1978Date of Patent: October 21, 1980Assignee: Boehringer Mannheim GmbHInventors: Wolfgang Kampe, Kurt Stach, deceased, by Werner Plattner, administrator, Max Thiel, Wolfgang Bartsch, Karl Dietmann, Egon Roesch, Wolfgang Schaumann
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Patent number: 4172136Abstract: New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO-NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.Type: GrantFiled: March 23, 1978Date of Patent: October 23, 1979Assignee: Boehringer Mannheim GmbHInventors: Herbert Berger, Rudi Gall, Kurt Stach, deceased, Max Thiel, Wolfgang Vomel
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Patent number: 4151303Abstract: Novel phenoxyalkylcarboxylic acid compounds of the formula ##STR1## wherein A is aryl, aryloxy, substituted aryl or substituted aryloxy, wherein the substituents are selected from lower alkyl, lower alkoxy, halogen and haloalkyl;B is a straight-chained or branched, saturated or unsaturated hydrocarbyl containing up to 5 carbon atoms;N is 1, 2 or 3 andR.sub.1, r.sub.2 and R.sub.3, which may be the same or different, are hydrogen or lower alkyl;And the pharmacologically compatible salts thereof; have been found to be outstandingly effective in depressing serum-lipid and triglycerides in the serum of mammals.Type: GrantFiled: September 1, 1976Date of Patent: April 24, 1979Assignee: Boehringer Mannheim GmbHInventors: Ernst-Christian Witte, Hans P. Wolff, Kurt Stach, deceased, Wolfgang Schaumann, Karlheinz Stegmeier
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Patent number: 4113871Abstract: Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, andR is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.Type: GrantFiled: April 8, 1976Date of Patent: September 12, 1978Assignee: Boehringer Mannheim GmbHInventors: Kurt Stach, deceased, Elmar Bosies, Ruth Heerdt, Hans-Frieder Kuhnle, Felix Helmut Schmidt
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Patent number: 4107299Abstract: 12-Epi-digoxins of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen or a lower alkanoyl or alkyl radical,R.sub.3 is hydrogen or a lower alkanoyl radical, andR.sub.4 is hydrogen or a lower alkyl, alkenyl or alkynyl radical,Are characterized by marked cardioactivity and therapeutic spectrum. They are produced by reduction of the corresponding 12-dehydrodigoxin.Type: GrantFiled: November 4, 1976Date of Patent: August 15, 1978Assignee: Boehringer Mannheim GmbHInventors: Fritz Kaiser, Wolfgang Schaumann, Kurt Stach, deceased, by Werner Plattner, administrator, Wolfgang Voightlander
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Patent number: 4105772Abstract: New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO--NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof, are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.Type: GrantFiled: November 22, 1976Date of Patent: August 8, 1978Assignee: Boehringer Mannheim GmbHInventors: Herbert Berger, Rudi Gall, Kurt Stach, deceased, by Werner Plattner, administrator, Max Thiel, Wolfgang Vomel
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Patent number: 4092416Abstract: Benzopyrones of the formula ##STR1## wherein R.sub.1 is a hydrogen or halogen atom or a hydroxyl, lower alkyl, alkoxy, alkylthio or trifluoromethyl radical,R.sub.2, r.sub.3, r.sub.4 and R.sub.5 each independently is hydrogen, a halogen atom, a hydroxyl radical, a lower alkyl or lower alkoxy radical, or a lower alkyl or lower alkoxy radical substituted by at least one of hydroxyl, halogen, mesyloxy or tosyloxy or by an oxirane, dioxane or dioxolane ring,A is a lower alkylene radical, andn is 0, 1 or 2,And salts thereof exhibit anti-allergic activity.Type: GrantFiled: December 1, 1976Date of Patent: May 30, 1978Assignee: Boehringer Mannheim GmbHInventors: Werner Winter, Max Thiel, Kurt Stach, deceased, Androniki Roesch, by Werner Plattner, administrator, Wolfgang Schaumann
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Patent number: 4087520Abstract: An L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine peptide of the formula ##STR1## wherein A is an alkylene radical which can be substituted by a hydroxyl group or by a phenyl radical which optionally carries at least one hydroxyl group, andR is a hydrogen atom or a lower alkyl radical or a glycyl or alanyl radical,Or a pharmacologically compatible salt thereof. These compounds are outstanding in lowering blood pressure.Type: GrantFiled: March 9, 1976Date of Patent: May 2, 1978Assignee: Boehringer Mannheim GmbHInventors: Franz Braun, Kurt Stach, deceased, by Werner Plattner, executor, Max Thiel, Gisbert Sponer, Karl Dietmann
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Patent number: 4086347Abstract: 9-[3-(4-Phenoxymethylpiperidino)-propyl]-adenines of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl radical,R.sub.2 is a hydrogen atom, a ower alkyl radical optionally substituted by hydroxyl, or a cycloalkyl radical, orR.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a heterocyclic ring, andR.sub.3 is a hydrogen atom, a halogen atom, a lower alkyl radical or a lower alkoxy radical,In the form of the free base or a salt thereof, exhibit anti-allergic, anti-inflammatory, anti-oedematous and anti-hypertensive activity.Type: GrantFiled: November 2, 1976Date of Patent: April 25, 1978Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Max Thiel, Kurt Stach, deceased, by Werner Plattner, administrator, Otto-Henning Wilhelms, Erika VON Mullendorff, Gisbert Sponer
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Patent number: 4070373Abstract: Novel tricyclic aminoalkyl derivatives are disclosed which are characterized by valuable pharmacological activities and namely by cardiac and circulatory activities. The tricyclic aminoalkyl derivatives are compounds of the formula: ##STR1## wherein X is an oxygen or a sulfur atom, a saturated or unsaturated, straight chain or branched alkylene group containing up to 3 carbon atoms, an oxymethylene, thiamethylene or thiaethylene group or a valency bond, R.sub.1 is hydrogen, halogen, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen or hydroxyl, R.sub.3 is hydrogen or together with R.sub.2 represents a further valency bond, R.sub.4 and R.sub.Type: GrantFiled: September 22, 1972Date of Patent: January 24, 1978Assignee: C.F. Boehringer & Soehne GmbHInventors: Werner Winter, Max Thiel, Kurt Stach, deceased, by Werner Plattner, administrator, Wolfgang Schaumann, Karl Dietmann
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Patent number: 4034096Abstract: New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.Type: GrantFiled: July 14, 1975Date of Patent: July 5, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Alfred Rhomberg, Herbert Berger, Kurt Stach, deceased, by Werner Plattner, administrator, Wolfgang Vomel, Winfriede Sauer
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Patent number: 4033967Abstract: New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.Type: GrantFiled: October 17, 1974Date of Patent: July 5, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Alfred Rhomberg, Herbert Berger, Kurt Stach, deceased, Werner Plattner, administrator, Wolfgang Vomel, Winfriede Sauer
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Patent number: 4016262Abstract: N(6)-disubstituted adenosine compounds of the formula: ##STR1## wherein R.sub.1 is alkenyl, cycloalkenyl or cycloalkenyl-alkyl; andR.sub.2 is alkenyl, cycloalkenyl, straight or branched-chain alkyl, cycloalkyl, bicycloalkyl, alkyl-cycloalkyl, or alkyl-bicycloalkyl;And the pharmacologically compatible salts thereof; exhibit outstanding anti-lipolytic, anti-hyperlipaemic and anti-hypercholesterolaemic action.Type: GrantFiled: May 30, 1975Date of Patent: April 5, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Erich Fauland, Wolfgang Kampe, Kurt Stach, deceased, by Werner Plattner, executor, Harald Stork, Karl Dietmann
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Patent number: 3988460Abstract: Certain novel cyclopentenoquinolone derivatives of the formula: ##SPC1##WhereinR and X, which may be the same or different, are hydrogen or lower saturated or unsaturated aliphatic hydrocarbyl;Y is hydroxyl or lower alkoxy or lower acyloxy (i.e., alkanoyloxy); andZ is hydrogen or lower alkoxy, or, together with Y, represents an oxo or lower alkenyldioxy radical; and the pharmacologically compatibile salts thereofAre outstandingly effective as anti-microbials, particularly for applications against infections of the urinary tract.Type: GrantFiled: March 13, 1975Date of Patent: October 26, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Alfred Rhomberg, Herbert Berger, Kurt Stach, deceased, by Werner Plattner, executor, Wolfgang Vomel, Winfriede Sauer