Patents by Inventor Kurt Stoepel

Kurt Stoepel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optically active 1,4-dihydropyridine esters useful for treating circulatory illnesses
    Patent number: 4988717
    Abstract: The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: March 30, 1989
    Date of Patent: January 29, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Friedrich Bosseret, Wulf Vater, Robertson Towart, Kurt Stoepel, Stanislav Kazda
  • The compound, (.revreaction.)1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5- dicarboxylic acid, methyl isobutyl ester, compositions containing same and a method for effecting coronary dilation
    Patent number: 4849433
    Abstract: The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: February 9, 1987
    Date of Patent: July 18, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Friedrich Bossert, Wulf Vater, Robertson Towart, Kurt Stoepel, Stanislav Kazda
  • Isopropyl 2-(3-trifluoromethylphenoxy)-ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate as vaso-dilators
    Patent number: 4675329
    Type: Grant
    Filed: June 27, 1985
    Date of Patent: June 23, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Andreas Knorr, Kurt Stoepel, Arend Heise
  • Vasodilating cyanoalkyl esters of 1,4-dihydropyridines
    Patent number: 4551467
    Abstract: The invention relates to 1,4-dihydropyridines as well as methods for the preparation of said 1,4-dihydropyridines and compositions contained therein. The invention also includes the use of said compounds and compositions for influencing circulation.
    Type: Grant
    Filed: October 11, 1979
    Date of Patent: November 5, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert, Wulf Vater, Kurt Stoepel
  • 1,4-Dihydro-2,6-dimethyl-4-(2'-chlorophenyl)-3,5-dicarboxylic acid,methyl or ethyl,trifluoroethyl ester
    Patent number: 4510310
    Abstract: The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: April 9, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Friedrich Bossert, Wulf Vater, Robertson Towart, Kurt Stoepel, Stanislay Kazda
  • 1,4-Dihydropyridazine compounds, and their medicinal use
    Patent number: 4360520
    Abstract: The invention includes new 1,4-dihydropyridazine compounds, compositions containing said 1,4-dihydropyridazine compounds and methods for the use of said compounds and compositions. Also included in the invention are methods for preparing the new 1,4-dihydropyridazine compounds.
    Type: Grant
    Filed: September 11, 1978
    Date of Patent: November 23, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Meyer, Gerhard Franckowiak, Friedrich Bossert, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Egbert Wehinger
  • 1,4-Dihydropyridazine compounds
    Patent number: 4348395
    Abstract: The invention includes, as novel compounds, 1,4-dihydropyridazines and methods for their preparation. Also included are compositions containing said compounds and methods for the use of said compounds and compositions. The compounds of the invention are active as circulation-influencing and spasmolytically active agents.
    Type: Grant
    Filed: October 4, 1978
    Date of Patent: September 7, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Franckowiak, Horst Meyer, Friedrich Bossert, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Egbert Wehinger
  • 2-Amino-3a,4,5,6-tetrahydro-perimidine derivatives and their medicinal use in combatting circulatory diseases
    Patent number: 4328223
    Abstract: The invention includes new 2-amino-3a,4,5,6-tetrahydro-perimidines and method for their preparation from corresponding racemacic compounds. Also included in the invention are pharmaceutical compositions containing said 2-amino-3a,4,5,6-tetrahydro-perimidines and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: April 5, 1979
    Date of Patent: May 4, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Joachim Kabbe, Hildegard E. Mayer, Annedore Mayer, Andrea Mayer, Heinz Ziemann, Kurt Stoepel
  • Nitro-substituted 1,4-dihydropyridines, processes for _their production and their medicinal use
    Patent number: 4248873
    Abstract: The invention includes novel nitro-substituted 1,4-dihydropyridines useful because of their influence on the circulation. Also included in the invention are methods for the preparation of said novel nitro-substituted 1,4-dihydropyridines, compositions containing them and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: November 6, 1978
    Date of Patent: February 3, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Friedrich Bossert, Gerhard Franckowiak, Arend Heise, Stanislav Kazda, Horst Meyer, Kurt Stoepel, Robertson Towart, Egbert Wehinger
  • 1,4-Dihydropyridine derivatives substituted in the 2 position, and their use as medicaments
    Patent number: 4188395
    Abstract: The present invention provides 1,4-dihydropyridine derivatives of the formula in which ##STR1## R represents hydrogen, alkyl, alkenyl, alkoxyalkyl, aryl or aralkyl, the alkyl and aryl groups being optionally substituted,A represents a straight-chain or branched alkylene radical,R.sup.1 represents (a) an optionally substituted alkylthio group or (b) a group of the formula O--CO-alkyl, O--CO-aryl or O--CO-aralkyl, the alkyl and aryl groups being optionally substituted or (c) a phthalimido radical which is optionally substituted in the benzene ring, Y and Z are identical or different and each represents a group of the formula COOR.sup.2 or COR.sup.2,whereinR.sup.2 represents alkyl, alkenyl, alkinyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl or aralkyl, the alkyl and aryl radicals being optionally substituted, orY and Z are identical or different and each represents a cyano radical or a radical of the formula S(O).sub.n --R.sup.3,whereinR.sup.
    Type: Grant
    Filed: December 1, 1977
    Date of Patent: February 12, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Friedrich Bossert, Egbert Wehinger, Horst Meyer, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Wulf Vater, Klaus Schlossmann
  • 1,4-Dihydropyridine-sugar derivatives, and their use as medicaments
    Patent number: 4179500
    Abstract: The invention concerns the provision of novel 1,4-dihydropyridine-sugar derivatives and processes for their preparation. The invention also concerns pharmaceutical compositions containing the compounds of the invention and methods for their use. The products of the invention, such as 2-[1,4-dihydro-5-(2-propyl)-oxycarbonyl-2,6-dimethyl-4-m-nitrophenyl-3- pyridylcarbonyloxy]-ethyl .beta.-D-glucopyranoside, are effective for the treatment of circulatory disorders and can be used as antihypertensive agents, vasodilators or coronary therapeutic agents.
    Type: Grant
    Filed: August 26, 1977
    Date of Patent: December 18, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bodo Junge, Friedrich Bossert, Horst Meyer, Egbert Wehinger, Wulf Vater, Arend Heise, Stanislav Kazda, Kurt Stoepel
  • 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use
    Patent number: 4177278
    Abstract: The invention includes the provision of 2-alkyleneaminodihydropyridines and salts thereof and are useful, inter alia, as coronary dilators and antihypertensive agents. Also included in the invention are pharmaceutical compositions containing said 2-alkyleneaminodihydropyridines and methods of treatment involving the use of said compounds or compositions.
    Type: Grant
    Filed: March 15, 1978
    Date of Patent: December 4, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Friedrich Bossert, Egbert Wehinger, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Wulf Vater, Klaus Schlossmann
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ester, and its use as a peripheral vasodilator
    Patent number: 4166855
    Abstract: The invention provides a novel compound, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid isopropyl 2-propoxyethyl ester and processes for its preparation. In addition, the invention includes the provision of compositions containing the compound of the invention and methods for treating warm-blooded animals for peripheral perfusion disturbances.
    Type: Grant
    Filed: October 6, 1977
    Date of Patent: September 4, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert, Horst Meyer, Arend Heise, Stanislav Kazda, Kurt Stoepel, Wulf Vater
  • Sulphur-containing amino-dihydropyridines, and their use as medicants
    Patent number: 4162321
    Abstract: The invention relates to new dihydropyridines which are substituted by an amino group in at least one of the 2- and 6-positions, by a sulphur-containing substituent in the 3-position, by a cyclic substituent in the 4-position and by a carbonyl substituent in the 5-position. The new dihydropyridines are particularly useful as agents which influence the circulatory system. Also included in the invention are procedures for preparation of the new dehydropyridines, compositions containing them and methods for their use.
    Type: Grant
    Filed: August 26, 1977
    Date of Patent: July 24, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert, Horst Meyer, Gerhard Franckowiak, Wulf Vater, Arend Heise, Stanislav Kazda, Kurt Stoepel
  • 2,6-Dimethyl -3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
    Patent number: 4154839
    Abstract: The isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate demonstrates the unique ability of increasing myocardial perfusion upon oral or intravenous administration. Methods of preparing the compound, its use in coronary conditions and pharmaceutical compositions for effecting that use are disclosed.
    Type: Grant
    Filed: May 8, 1978
    Date of Patent: May 15, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert, Arend Heise, Stanislav Kazda, Kurt Stoepel, Wulf Vater
  • Aminoalkylideamino-1,4-dihydropyridines and their use as medicaments
    Patent number: 4146627
    Abstract: The circulation provides new aminoalkylidene-amino-1,4-dihydropyridines which influence the circulatory system and are useful, for instance, as antihypertensive agents. Also included in the invention are methods for the preparation of said dihydropyridines, compositions containing them and methods for their use.
    Type: Grant
    Filed: August 26, 1977
    Date of Patent: March 27, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert, Horst Meyer, Wulf Vater, Arend Heise, Stanislav Kaada, Kurt Stoepel
  • Antihypertensive 2-amino-4,5-dihydropyridine derivatives
    Patent number: 4136187
    Abstract: 4,5-Dihydropyridines bearing an N,N-disubstituted amino group in the 2-position, carbonyl functions in the 3- and 5-positions and being optionally substituted in the 6-position by lower alkyl or phenyl and, in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-pyrrolidino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxy lic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a substituted 3,3-diaminoacrylate.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: January 23, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Meyer, Friedrich Bossert, Wulf Vater, Kurt Stoepel
  • 1,2-Pentamethylene-1,4-dihydropyridine derivatives
    Patent number: 4053614
    Abstract: 1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, and being fused through the 1- and 2-positions to a five, six or seven membered cycloalkyl ring, one methylene group of which can be replaced by sulfur, oxygen imino or alkylimino, are anti-hypertensive agents and coronary vessel dilators. The compounds, of which 6-methyl-4-(3-nitrophenyl)-1,2-pentamethylene-1,4-dihydropyridine-3,5-dica rboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a cyclic enamino carbonyl derivative.
    Type: Grant
    Filed: August 13, 1975
    Date of Patent: October 11, 1977
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Meyer, Friedrich Bossert, Wulf Vater, Kurt Stoepel
  • 4-Quinoline and isoquinoline substituted 2,6-diamino-1,4-dihydropyridine derivatives
    Patent number: 4049662
    Abstract: 2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2,6-diamino-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an amidine with either an aldehyde or an ylidenecyanoacetoacetic acid ester.
    Type: Grant
    Filed: January 28, 1975
    Date of Patent: September 20, 1977
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Meyer, Friedrich Bossert, Wulf Vater, Kurt Stoepel
  • 1,4-Dihydropyridines
    Patent number: 4044141
    Abstract: 1,4-Dihydropyridines characterized by a carbo(arylalkoxy) group in the 5-position, an aryl group in the 4-position and a alkanoyl or carbalkoxy group in the 3-position and further optionally substituted in the 1,2 and 6-positions are coronary dilating, spasmolytic and hypotensive agents. The compounds, of which 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbobenzoxy-1,4-dihydropy ridine is a representative embodiment, are prepared through the reaction of an ylidene-.beta.-dicarbonyl compound, which may be generated in situ from the corresponding .beta.-dicarbonyl compound and an aldehyde, and an enaminocarboxylic acid ester, which may also be generated in situ from a .beta.-dicarbonyl compound and an amine.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: August 23, 1977
    Assignee: Bayer Aktiengesellschaft
    Inventors: Friedrich Bossert, Egbert Wehinger, Kurt Stoepel, Wulf Vater, Stanislav Kazda