Patents by Inventor Kurt Weindel
Kurt Weindel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120247150Abstract: This invention relates to magnetic particles having a glass surface which are substantially spherical. This invention also relates to methods for making them, as well as to suspensions thereof and their uses for the purification of DNA or RNA in particular in automated processes.Type: ApplicationFiled: February 13, 2012Publication date: October 4, 2012Applicant: Roche Diagnostics GmbHInventors: Kurt Weindel, Michael Riedling, Albert Geiger
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Patent number: 8129118Abstract: This invention relates to magnetic particles having a glass surface which are substantially spherical. This invention also relates to methods for making them, as well as to suspensions thereof and their uses for the purification of DNA or RNA in particular in automated processes.Type: GrantFiled: May 11, 2005Date of Patent: March 6, 2012Assignee: Roche Diagnostics GmbHInventors: Kurt Weindel, Michael Riedling, Albert Geiger
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Patent number: 8026068Abstract: This invention relates to a method for the isolation of a target nucleic acid using a material with an unmodified silica surface and subsequent amplification of the target nucleic acid in the presence of the material with an unmodified silica surface. The method is preferably carried out as an automated process preferably in a high throughput format. The method is preferably used in diagnostics.Type: GrantFiled: January 6, 2003Date of Patent: September 27, 2011Assignee: Roche Molecular Systems, Inc.Inventors: Judith Pinsl-Ober, Peter Wenzig, Ralf Schoenbrunner, Patrick O'Donnell, Erich Kyger, Khushbeer Malhotra, Kurt Weindel, Knut Bartl
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Patent number: 7560231Abstract: The present invention is related to compounds comprising mannitol or glucitol derivatives which may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are disclosed wherein the oligomeric compounds are used.Type: GrantFiled: December 5, 2003Date of Patent: July 14, 2009Assignee: Roche Molecular Systems, Inc.Inventors: Frank Bergmann, Herbert Von Der Eltz, Christoph Seidel, Kurt Weindel
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Patent number: 7329491Abstract: A method for purification of a nucleic acid comprising the steps of (a) adsorbing on a substrate the nucleic acid from a composition containing (i) an aqueous buffer, (ii) salts in a high concentration, (iii) a water-miscible, non-acidic organic compound, and (iv) the nucleic acid; (b) optionally washing with a washing solution the substrate with the adsorbed nucleic acid; (c) contacting the substrate with the adsorbed nucleic acid with a solution containing salts in a lower concentration compared to the composition of step (a), thereby desorbing the nucleic acid from the substrate; (d) separating the solution with the desorbed nucleic acid from the substrate, thereby purifying the nucleic acid; and optionally (e) precipitating the desorbed nucleic acid from the solution of step (d) and isolating the precipitated nucleic acid, thereby further purifying the nucleic acid.Type: GrantFiled: October 12, 2004Date of Patent: February 12, 2008Assignee: Roche Diagnostics Operations, Inc.Inventors: Michael Kirchgesser, Frank Bergmann, Thomas Walter, Kurt Weindel, Ralf Zielenski, Emad Sarofim
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Publication number: 20050266462Abstract: This invention relates to magnetic particles having a glass surface which are substantially spherical. This invention also relates to methods for making them, as well as to suspensions thereof and their uses for the purification of DNA or RNA in particular in automated processes.Type: ApplicationFiled: May 11, 2005Publication date: December 1, 2005Inventors: Kurt Weindel, Michael Riedling, Albert Geiger
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Publication number: 20050079535Abstract: A method for purification of a nucleic acid comprising the steps of (a) adsorbing on a substrate the nucleic acid from a composition containing (i) an aqueous buffer, (ii) salts in a high concentration, (iii) a water-miscible, non-acidic organic compound, and (iv) the nucleic acid; ( b) optionally washing with a washing solution the substrate with the adsorbed nucleic acid; (c) contacting the substrate with the adsorbed nucleic acid with a solution containing salts in a lower concentration compared to the composition of step (a), thereby desorbing the nucleic acid from the substrate; (d) separating the solution with the desorbed nucleic acid from the substrate, thereby purifying the nucleic acid; and optionally (e) precipitating the desorbed nucleic acid from the solution of step (d) and isolating the precipitated nucleic acid, thereby further purifying the nucleic acid.Type: ApplicationFiled: October 12, 2004Publication date: April 14, 2005Inventors: Michael Kirchgesser, Frank Bergmann, Thomas Walter, Kurt Weindel, Ralf Zielenski, Emad Sarofim
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Publication number: 20040191794Abstract: The present invention is directed to a method for the determination of at least 3 analytes using specific binding partners. Combinations of detectable labels are coupled to the binding partners assuring that each binding partner molecule is coupled with only one detectable label. This allows the determination of more different analytes than different labels used by not limiting the range of useable labels. The present invention is also related to kits, composition of matters and their use.Type: ApplicationFiled: February 26, 2004Publication date: September 30, 2004Inventors: Kurt Weindel, Stefan Kraiss, Frank Bergmann, Hans-Peter Josel, Dieter Heindl
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Patent number: 6790623Abstract: The discriminating capability of hybridization assays is increased by a combination of labelled primers which produce amplificates of one strand of a nucleic acid with a capture probe which is complementary to the same strand of the nucleic acid.Type: GrantFiled: March 22, 2002Date of Patent: September 14, 2004Assignee: Roche Diagnostics GmbHInventors: Kurt Weindel, Joachim Brand
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Publication number: 20040157247Abstract: The present invention is related to compounds comprising mannitol or glucitol derivatives which may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are disclosed wherein the oligomeric compounds are used.Type: ApplicationFiled: December 5, 2003Publication date: August 12, 2004Applicant: ROCHE MOLECULAR SYSTEMS, INCInventors: Frank Bergmann, Herbert Von Der Eltz, Christoph Seidel, Kurt Weindel
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Publication number: 20040014070Abstract: This invention relates to a method for the isolation of a target nucleic acid using a material with an unmodified silica surface and subsequent amplification of the target nucleic acid in the presence of the material with an unmodified silica surface. The method is preferably carried out as an automated process preferably in a high throughput format. The method is preferably used in diagnostics.Type: ApplicationFiled: January 6, 2003Publication date: January 22, 2004Inventors: Judith Pinsl-Ober, Peter Wenzig, Ralf Schoebrunner, Patrick O'Donnell, Erich Kyger, Khushbeer Malhotra, Kurt Weindel, Knut Bartl
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Publication number: 20030224366Abstract: This invention relates to magnetic particles having a glass surface which are substantially spherical. This invention also relates to methods for making them, as well as to suspensions thereof and their uses for the purification of DNA or RNA in particular in automated processes.Type: ApplicationFiled: May 16, 2002Publication date: December 4, 2003Inventors: Kurt Weindel, Michael Riedling, Albert Geiger
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Publication number: 20030152937Abstract: The discriminating capability of hybridization assays is increased by a combination of labelled primers which produce amplificates of one strand of a nucleic acid with a capture probe which is complementary to the same strand of the nucleic acid.Type: ApplicationFiled: March 22, 2002Publication date: August 14, 2003Applicant: ROCHE DIAGNOSTICS GmbHInventors: Kurt Weindel, Joachim Brand
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Patent number: 6503714Abstract: The invention concerns a method of detecting a substance to be analyzed in a sample by contacting the sample with a probe which contains nucleobases and two or more non-nucleosidic marker-promoting groups in conditions in which the substance to be analyzed binds indirectly or directly to the probe. The method enables the binding product to be detected. The probe is preferably branched.Type: GrantFiled: November 16, 2000Date of Patent: January 7, 2003Assignee: Roche Diagnostics GmbHInventors: Kurt Weindel, Christoph Seidel, Gerhard Lassonczyk
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Patent number: 6447999Abstract: The combination of two mechanisms of detection in a single device yields a method which allows the simple quantification of analyte determinations. Suitable formats and reagent kits are suggested.Type: GrantFiled: February 16, 1999Date of Patent: September 10, 2002Assignee: Roche Diagnostics GmbHInventors: Ursula Giesen, Peter Wenzig, Günter Ziegler, Kurt Weindel
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Patent number: 6410235Abstract: The discriminating capability of hybridization assays is increased by a combination of labelled primers which produce amplificates of one strand of a nucleic acid with a capture probe which is complementary to the same strand of the nucleic acid.Type: GrantFiled: June 4, 1999Date of Patent: June 25, 2002Assignee: Roche Diagnostics GmbHInventors: Kurt Weindel, Joachim Brand
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Patent number: 6214549Abstract: The invention concerns a method of detecting a substance to be analyzed in a sample by contacting the sample with a probe which contains nucleobases and two or more non-nucleosidic marker-promoting groups in conditions in which the substance to be analyzed binds indirectly or directly to the probe. The method enables the binding product to be detected. The probe is preferably branched.Type: GrantFiled: September 10, 1998Date of Patent: April 10, 2001Assignee: Roche Diagnostics GmbHInventors: Kurt Weindel, Christoph Seidel, Gerhard Lassonczyk
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Patent number: 6197594Abstract: The present invention concerns a method for the detection of an analyte in a sample liquid by luminescence measurement according to the principle of a ligand-receptor assay, e.g. an immunoassay or a hybridization assay or a combination thereof, wherein a sample liquid is incubated with at least one receptor which carries a luminescent label and the presence or/and the amount of the analyte to be detected is determined in the sample liquid by measuring the luminescence in a measuring medium containing dispersed components.Type: GrantFiled: November 3, 1995Date of Patent: March 6, 2001Assignee: Roche Diagnostics GmbHInventors: Kurt Weindel, Hans Hornauer
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Patent number: 5830762Abstract: Methods of optimising binding assays are disclosed using binding agents having binding sites specific for an analyte by varying the density of binding sites on a solid phase, advantageously extending the working range of the assay and/or improving the precision of the assay within a given range. Processes for manufacturing an assay kit following the optimisation method and to methods of carrying out assays for analytes using these assay kits are also provided.Type: GrantFiled: February 6, 1997Date of Patent: November 3, 1998Assignee: Boehringer Mannheim GmbHInventor: Kurt Weindel