Patents by Inventor Kurt William Vogel

Kurt William Vogel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KINASE AND UBIQUINATION ASSAYS
    Publication number: 20100151484
    Abstract: Compositions, including antibodies, polypeptides, and organic molecules, kits, and methods for probing molecular interactions (e.g., deubiquination, ubiquination and kinase activity), e.g., using resonance energy transfer (RET) are provided.
    Type: Application
    Filed: July 23, 2009
    Publication date: June 17, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kurt William VOGEL, Steven Michael Riddle, Robert Aron Horton, Matthew Brian Robers, Gregory Allen Michaud, Thomas Machleidt, Kevin Vedvik, Kristin G. Huwiler
  • Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy
    Patent number: 6921531
    Abstract: Bifunctional molecules and methods for their use in the production of binary or tripartite complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. The molecular weight of the bifunctional molecule is less than about 5000 daltons. In the methods, an effective amount of the bifunctional molecule is administered to the host. In certain embodiments the bifunctional molecule binds to the presenter protein and a drug target to produce a tripartite complex, while in other embodiments the bifunctional molecule binds to either the presenter protein or the drug target, but not both, to produce a binary complex The subject methods and compositions find use in a variety of therapeutic applications.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: July 26, 2005
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Howard Hughes Medical Institute
    Inventors: Roger Briesewitz, Gerald R. Crabtree, Thomas Wandless, Gregory Thomas Ray, Kurt William Vogel
  • Bifunctional molecules and therapies based thereon
    Publication number: 20020147133
    Abstract: Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. In the subject methods, an effective amount of the bifunctional molecule is administered to the host. The bifunctional molecule binds to the presenter protein to produce a binary complex that exhibits at least one of improved affinity, specificity or selectivity as compared to the corresponding free drug. The subject methods and compositions find use in a variety of therapeutic applications.
    Type: Application
    Filed: December 21, 2001
    Publication date: October 10, 2002
    Inventors: Roger Briesewitz, Gerald R. Crabtree, Thomas Wandless, Gregory Thomas Ray, Kurt William Vogel
  • Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
    Patent number: 6372712
    Abstract: Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. The molecular weight of the bifunctional molecule is preferably less than about 5000 daltons, and the drug moiety may have a molecular weight of from about 50 to 2000 daltons. The drug moiety and presenter protein ligand may be covalently linked directly or through a linking group. The drug moiety binds to a drug target such as a protein and the presenter protein ligand binds to a presenter protein that is not the drug target such as extracellular or intracellular protein. Presenter proteins include peptidyl prolyl isomerase (FKBP), Heat Shock Protein 90 (Hsp90), steroid hormone receptors, cytoskeletal proteins, albumin and vitamin receptors.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: April 16, 2002
    Assignees: The Board of Trustees of the Leland Stanford Jr. University, The Howard Hughes Medical Institute
    Inventors: Roger Briesewitz, Gerald R. Crabtree, Thomas Wandless, Gregory Thomas Ray, Kurt William Vogel