Abstract: The present disclosure relates to isoxazolidines and their use as receptor-interacting protein kinase 1 inhibitors, for example in the treatment of diseases and disorders mediated by RIP kinase 1.

Abstract: A roller press for compacting fine-grained chemicals, especially salts, into sheets, having synchronously driven rollers with two axially spaced pressing surfaces on ring elements being provided with radial shoulders at both of their ends. Screw feeders for feeding the salt into the roll nip and wedge-shaped wall elements closing-off the roll nip in the axial direction on both ends of said ring elements and bearing against the shoulders, are also provided. Adjustment rods acting parallel to the roll axis are provided for the outer wall elements and vertical rods between the inner wall elements acting onto these wall elements via wedge-shaped surfaces arranged on said rods and the walls of said wall elements facing each other. The ring elements are integral with the roller bodies or separate cylindrical rings shrink-fit onto the roller bodies. Each ring element is associated with at least two screw feeders.

Abstract: The invention relates to a roll briquetting press having a preconnected feed arrangement including a multiplicity of juxtaposed screw conveyors.