Patents by Inventor Kuzhalmannam L. Ramachandran

Kuzhalmannam L. Ramachandran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid probe linked to a label having a terminal cysteine
    Patent number: 5109124
    Abstract: A polynucleotide probe with a label bearing a plurality of signalling moieties. The label is attached to the probe by the reaction of an amino and sulfhydryl reactive hetero bifunctional reagent with the probe and label, the reaction resulting in the oxidation of a sulfhydryl group of the label. The label may be attached to the 5' terminus of the probe, or to modified bases of the probe. Probes constructed according to the invention are useful in detecting target sequences in genomic DNA.
    Type: Grant
    Filed: February 2, 1989
    Date of Patent: April 28, 1992
    Assignee: Biogen, Inc.
    Inventors: Kuzhalmannam L. Ramachandran, Richard L. Cate
  • Peptides involved in the pathogenesis of HIV infection
    Patent number: 5017688
    Abstract: This invention relates to peptides involved in the pathogenesis of human immunodeficiency virus ("HIV"). More particularly, this invention relates to peptides from the env region of the HIV genome and the use of such peptides in methods and compositions for preventing, treating, or detecting acquired immune deficiency syndrome ("AIDS") infection.
    Type: Grant
    Filed: October 30, 1989
    Date of Patent: May 21, 1991
    Assignee: Biogen, Inc.
    Inventors: Walter Gilbert, Richard A. Fisher, Vicki L. Sato, Kuzhalmannam L. Ramachandran