Abstract: A sensor device includes: a support structure having a cantilever shape extending in a first direction and having a first end fixed; a sensing element having a surface and a resonant frequency changing according to contaminants adsorbed to the surface and disposed at a second end of the support structure; a frequency detector configured to detect the resonant frequency of the sensing element; and an actuator disposed at the one end of the support structure and configured to move the support structure so that the second end of the support structure moves in a second direction perpendicular to the first direction.

Abstract: The present invention relates to a tire including a fabric strip, and the tire includes a fabric strip in a belt layer, the fabric strip including a plurality of warps arranged in parallel to one another and wefts arranged to weave the warps. The tire according to the invention is advantageous in that the production process is simplified, the production cost required during the production process is lowered, the weight of the tire is reduced, and the fuel efficiency is increased when a car using the tire of the invention is driven, by reducing the resistance to rolling.

Abstract: A tire including a sealant layer and a sound absorbing material layer is provided, and more particularly, a tire is provided, which includes a sound absorbing material layer which is attached to an inner surface of a tire, and a sealant layer which is disposed between the inner surface of the tire and the sound absorbing material layer and includes a sealant which attaches the sound absorbing material layer to the inner surface of the tire. The sound absorbing material layer includes a non-woven fabric.

Abstract: The present invention provides a method for synthesizing etelcalcetide or salts thereof, comprising the steps of: (a) synthesizing the D-amino acids in the formula (I) sequentially by Fmoc solid-phase synthesis, using a solid support as a starting material in solid phase peptide synthesis and sequentially synthesizing a D-form amino acid of formula (I) by Fmoc chemistry; deprotecting Fmoc group and acetylating the amino group to obtain a sequence A comprising protecting groups (PG) in the side chain of D-Cys and D-Arg; (b) removing the protecting group in the side-chain of D-Cys of the sequence A to form a sequence B; (c) disulfide formation at D-Cys of the sequence B by (PG)-L-Cys-OH to obtain a sequence C; (d) using a cleavage solution to remove the protecting groups of the sequence C to give etelcalcetide as formula (I). The present invention can shorten the steps and time for preparing Etelcalcetide.

Abstract: Methods, devices, and systems for solving the problem of management and tracking of collection, processing, and movement of biological samples during clinical trials are disclosed herein. According to one embodiment, a method is implemented on one or more servers. The method includes receiving first biological sample data from a first mobile device. The first mobile device includes a camera for capturing at least a portion of the first biological sample data and a first graphical user interface (GUI) configured for displaying the first biological sample data. The method further includes storing the first biological sample data within a distributed ledger. The distributed ledger may include at least one block chain.

Abstract: The present disclosure relates to a rubber composition for a tire tread and a tire including the rubber composition for the tire tread. The rubber composition for the tire tread is capable of providing a tire of which handling performance and braking performance on the wet road surface or the ice and snow road surface are simultaneously improved by comprising: a raw material rubber including 20 to 50 parts by weight of a first styrene butadiene rubber, 20 to 50 parts by weight of a second styrene butadiene rubber, and 10 to 40 parts by weight of a butadiene rubber (BR); and 80 to 180 parts by weight of a reinforcing filler, 2 to 50 parts by weight of a natural oil, and 2 to 30 parts by weight of a hydrocarbon resin with respect to 100 parts by weight of the raw material rubber.

Abstract: The present invention provides a method for synthesizing etelcalcetide or salts thereof, comprising the steps of: (a) synthesizing the D-amino acids in the formula (I) sequentially by Fmoc solid-phase synthesis, using a solid support as a starting material in solid phase peptide synthesis and sequentially synthesizing a D-form amino acid of formula (I) by Fmoc chemistry; deprotecting Fmoc group and acetylating the amino group to obtain a sequence A comprising protecting groups (PG) in the side chain of D-Cys and D-Arg; (b) removing the protecting group in the side-chain of D-Cys of the sequence A to form a sequence B; (c) disulfide formation at D-Cys of the sequence B by (PG)-L-Cys-OH to obtain a sequence C; (d) using a cleavage solution to remove the protecting groups of the sequence C to give etelcalcetide as formula (I). The present invention can shorten the steps and time for preparing Etelcalcetide.

Abstract: A method for preparing 42-(dimethylphosphinate) Rapamycin (Ridaforolimus) (I) is provided, which has advantages of high conversion rate and no 31,42-bis(dimethyl phosphinate) Rapamycin (III) generated. In the method of the present invention, Rapamycin (II) is firstly reacted with triethyl chlorosilane in a base condition to form 31,42-bis(triethylsilylether) Rapamycin (IV-b), followed by a selective deprotection process to obtain 31-triethylsilylether Rapamycin (V-b). Next, a phosphorylation reaction is performed by using dimethylphosphinic chloride under a base solution to obtain a crude product. Finally, a deprotection reaction is performed in a diluted sulfuric acid solution to obtain a crude product of Ridaforolimus (I). Since the conversion rate of each step of the method of the present invention is higher than 98%, it indicates that the method of the present invention is suitable for industrial production.

Abstract: A method for preparing 42-(dimethylphosphinate) Rapamycin (Ridaforolimus) (I) is provided, which has advantages of high conversion rate and no 31,42-bis(dimethyl phosphinate) Rapamycin (III) generated. In the method of the present invention, Rapamycin (II) is firstly reacted with triethyl chlorosilane in a base condition to form 31,42-bis(triethylsilylether) Rapamycin (IV-b), followed by a selective deprotection process to obtain 31-triethylsilylether Rapamycin (V-b). Next, a phosphorylation reaction is performed by using dimethylphosphinic chloride under a base solution to obtain a crude product. Finally, a deprotection reaction is performed in a diluted sulfuric acid solution to obtain a crude product of Ridaforolimus (I). Since the conversion rate of each step of the method of the present invention is higher than 98%, it indicates that the method of the present invention is suitable for industrial production.

Abstract: The present invention provides two synthetic routes for the preparation of Temsirolimus (compound 1b and analog of Temsirolimus 1a). The first route includes the synthesis of CCI-779 by directly reacting rapamycin (4b) or Prolyl-rapamycin (4a) with substituent-2,2-bis(methoxy) propionic acid anhydride(11) in the presence of an organic base, followed by deprotection to give CCI-779 or Proline CCI-779. The second route includes a process involving a reaction of rapamycin-OH-31-sily ether (4d) or Prolyl-rapamycin-OH-31-sily ether (4c) with substituent-2,2-bis(methoxy) propionic acid anhydride(11) in the presence of an organic base and followed by subsequent hydrolysis step to obtain the desired CCI-779 or Proline CCI-779. Compound 11, as described in this invention, is stable at room temperature, cost effective and ease of processing.

Abstract: The best match of two time-uncertain series is quantified with a degree of confidence by selecting one of the time series and repeatedly computing a maximum covariance between the selected time series and a series of random records with the same distribution and expected autocorrelation as the non-selected time series. The resulting distribution of maximum covariances can be used to determine a degree of confidence by determining the percentage of those computed maxima which lie below the maximum covariance associated with the best match.

Abstract: A process for making Biolimus A9 comprises reacting sirolimus (or rapamycin) with alkyl benzene sulfonate under the catalyzing of organic base and in the presence of organic solvent to undergo a nucleophilic substitution reaction to obtain the Biolimus A9 with high yield, not only for small-scale laboratory experiment, but also for rendering reproducibility of high yield even after process amplification.

Abstract: The present invention provides two synthetic routes for the preparation of Temsirolimus (compound 1b and analog of Temsirolimus 1a). The first route includes the synthesis of CCI-779 by directly reacting rapamycin (4b) or Prolyl-rapamycin (4a) with substituent-2,2-bis(methoxy) propionic acid anhydride(11) in the presence of an organic base, followed by deprotection to give CCI-779 or Proline CCI-779. The second route includes a process involving a reaction of rapamycin-OH-31-sily ether (4d) or Prolyl-rapamycin-OH-31-sily ether (4c) with substituent-2,2-bis(methoxy) propionic acid anhydride(11) in the presence of an organic base and followed by subsequent hydrolysis step to obtain the desired CCI-779 or Proline CCI-779. Compound 11, as described in this invention, is stable at room temperature, cost effective and ease of processing.

Abstract: A process for making caspofungin acetate comprising the steps of: A. selectively dehydrating pneumocandin Bo to obtain a nitrile; B. reducing the nitrile to primary amine; C. reacting the primary amine with an arylthiol in a suitable solvent to obtain a thioether; and D.

Abstract: A process for making Biolimus A9 comprises reacting sirolimus (or rapamycin) with alkyl benzene sulfonate under the catalyzing of organic base and in the presence of organic solvent to undergo a nucleophilic substitution reaction to obtain the Biolimus A9 with high yield, not only for small-scale laboratory experiment, but also for rendering reproducibility of high yield even after process amplification.

Abstract: A method for controlling access to a handheld device (10) by validating voice sounds includes: setting voice characteristics acceptable error margin; storing voice characteristics of the original voice sounds of a user in a memory (12) of the handheld; recording validation voice sounds of the user through a microphone (11) in the handheld device; detecting voice characteristics of the validation voice sounds; determining whether the voice characteristics of the validation voice sounds matches the voice characteristics of the original voice sounds in the memory by comparing a difference between the voice characteristics of the validation voice sounds and the voice characteristics of the original voice sounds is within the voice characteristics acceptable error margin; and allowing the user to access the handheld device if the voice characteristics of the validation voice sounds matches the voice characteristics of the original voice sounds.

Abstract: This invention is directed to a vegetable protein composition comprising a protein material having low levels of isoflavones, low levels of phytic acid and/or phytates, and moderate levels of ribonucleic acids. Many vegetable compositions described additionally have high protein content, low manganese content, low ash content, and enhanced storage stability in liquid form. Processes for preparing such vegetable protein compositions are also disclosed.

Abstract: This invention relates to a polyelectrolyte composition for a humidity sensor, polyelectrolyte ink and a preparation method of a polyelectrolyte membrane for a humidity sensor by inkjet printing. The polyelectrolyte composition according to this invention is composed of polyelectrolyte, crosslinking agent and organic solvent comprising a single component or in the form of a mixture of two or more solvents such as alcohols. The object of this invention is to provide a polyelectrolyte composition and a polyelectrolyte ink composition suitable for humidity sensor and a preparation method for a reliable humidity sensor with uniform thickness achieved through inkjet printing.

Abstract: The present invention is to manufacture the organic silver solution by dissolving silver oxide in an organic solvent, and further provide an ink enabling a conductive circuit to be formed by applying it to an inkjet printer. Also, it is to provide a method for forming a conductive circuit on various substrates by printing it through the inkjet printer using the manufactured ink and further heat-treating it. The organic silver solution, a composition according to the present invention, can be manufactured by dissolving silver oxide in an amine-based compound and a lactone-based compound (or a lactam-based compound, a carbonate-based compound, a cyclic acid anhydride-based compound) by reacting the former an the latter, and in order to ensure the appropriate liquid fluidity for the inkjet printer, the ink was manufactured by adding an organic solvent, such as alcohol, a surfactant and the like thereto.

Abstract: Embodiments of the present invention may provide an apparatus and a method for transmitting a multi-carrier signal, the multi-carrier signal being generated by modulating a received digital signal. The received digital signal may be modulated to a first multi-carrier signal and a second multi-carrier signal. The first multi-carrier signal and the second multi-carrier signal may be combined to generate a combined multi-carrier signal, wherein the second multi-carrier signal is generated to have a same phase with a combined multi-carrier signal.