Abstract: Disclosed are a dental barrier membrane for guided bone regeneration using a silk matrix and a method of manufacturing the same, wherein the dental barrier membrane is configured such that a silk matrix having a cross-section with a first thickness, produced from silkworms, is subjected to planar division into two or more silk matrix pieces having a predetermined shape with the first thickness. This dental barrier membrane is biocompatible, has superior tensile strength and porosity, and promotes the formation of new bone in bone defects, unlike existing dental barrier membranes.

Abstract: Disclosed are a vascular patch using a silk matrix and a method of manufacturing the same, wherein the vascular patch is configured such that a silk matrix having a cross-section with a first thickness, produced from silkworms, is subjected to planar division into two or more silk matrix pieces having a predetermined shape with the first thickness. Furthermore, the manufacturing process is relatively simple, thus reducing the manufacturing cost compared to when manufacturing typical vascular patches, and also, the vascular patch can exhibit outstanding cell culture capacity and is biocompatible.

Abstract: Disclosed herein are a cocoon-based, vascular patch and a method for manufacturing the same. The cocoon-based, vascular patch is manufactured by dividing a cocoon into two or more fragments in a predetermined form, the cocoon having a shell having a predetermined thickness. The cocoon-based vascular patch can be relatively simply manufactured in a more cost efficient manner than conventional vascular patches, and has excellent cell growth potential and biocompatibility.

Abstract: Disclosed herein are a cocoon-based, dental barrier membrane for guided bone regeneration and a method for manufacturing the same. The cocoon-based, dental barrier membrane is manufactured by dividing a cocoon into two or more fragments in a predetermined form, the cocoon having a shell having a first thickness. The dental barrier membrane is biocompatible, has excellent tensile strength and porosity, and promotes osteogenesis in a bone defect.

Abstract: Disclosed are a vascular patch using a silk matrix and a method of manufacturing the same, wherein the vascular patch is configured such that a silk matrix having a cross-section with a first thickness, produced from silkworms, is subjected to planar division into two or more silk matrix pieces having a predetermined shape with the first thickness. Furthermore, the manufacturing process is relatively simple, thus reducing the manufacturing cost compared to when manufacturing typical vascular patches, and also, the vascular patch can exhibit outstanding cell culture capacity and is biocompatible.

Abstract: Disclosed are a dental barrier membrane for guided bone regeneration using a silk matrix and a method of manufacturing the same, wherein the dental barrier membrane is configured such that a silk matrix having a cross-section with a first thickness, produced from silkworms, is subjected to planar division into two or more silk matrix pieces having a predetermined shape with the first thickness. This dental barrier membrane is biocompatible, has superior tensile strength and porosity, and promotes the formation of new bone in bone defects, unlike existing dental barrier membranes.

Abstract: Disclosed are an artificial biomembrane using a silk matrix and a method of manufacturing the same, wherein the artificial biomembrane is configured such that a silk matrix having a cross-section with a first thickness, produced from silkworms, is subjected to planar division into two or more silk matrix pieces having a predetermined shape with the first thickness. Furthermore, the manufacturing process is relatively simple, thus reducing the manufacturing cost compared to when manufacturing typical artificial biomembranes, and moreover, the artificial biomembrane can exhibit outstanding cell culture capacity, is biocompatible, and has superior tensile strength and elongation, which are required of biomembranes.

Abstract: Disclosed herein are a cocoon-based, vascular patch and a method for manufacturing the same. The cocoon-based, vascular patch is manufactured by dividing a cocoon into two or more fragments in a predetermined form, the cocoon having a shell having a predetermined thickness. The cocoon-based vascular patch can be relatively simply manufactured in a more cost efficient manner than conventional vascular patches, and has excellent cell growth potential and biocompatibility.

Abstract: Disclosed herein are a cocoon-based, dental barrier membrane for guided bone regeneration and a method for manufacturing the same. The cocoon-based, dental barrier membrane is manufactured by dividing a cocoon into two or more fragments in a predetermined form, the cocoon having a shell having a first thickness. The dental barrier membrane is biocompatible, has excellent tensile strength and porosity, and promotes osteogenesis in a bone defect.

Abstract: Disclosed herein are a cocoon-based artificial biomembrane and a method for manufacturing the same. A cocoon the shell of which has a first thickness is divided into two or more fragments in predetermined form. The cocoon fragments may be used as artificial biomembranes. They can be relatively simply manufactured in a more cost efficient manner than conventional artificial biomembranes and have excellent cell growth potential. Also contemplated are a cocoon-based artificial biomembrane having excellent tensile strength and elongation, and a method for manufacturing the same.

Abstract: Disclosed is a method for the purification of bee venom on a mass scale. It comprises dissolving crude bee venom in a solvent to form a bee venom solution; applying an adsorbent to the bee venom solution to form a mixture; and removing the adsorbent through filtration to afford a pure bee venom solution. By the method of the present invention, crude bee venom collected from bee farms can be purified to a purity of 99% or higher on a mass scale, without inducing a change in the composition thereof, and thus the purified bee venom can be used as a material for medicines, cosmetics and foods.

Abstract: Disclosed is a method for the purification of bee venom on a mass scale. It comprises dissolving crude bee venom in a solvent to form a bee venom solution; applying an adsorbent to the bee venom solution to form a mixture; and removing the adsorbent through filtration to afford a pure bee venom solution.

Abstract: Provided is an artificial eardrum using silk protein and a method of fabricating the same. The artificial eardrum is fabricated in the form of a silk membrane by desalinating and drying silk protein (or silk fibroin) or a silk protein complex solution obtained after removal of sericin from a silkworm cocoon or silk fiber. Thus, regeneration of an eardrum perforated due to disease or a sudden accident is stimulated, a boundary of the regenerated eardrum is clean and biocompatibility and transparency are increased. In addition, the artificial eardrum may be fabricated using the silk protein or silk protein complex solution obtained from a silkworm cocoon alone or mixed with collagen, alginic acid, PEG or pluronic 127.

Abstract: Provided is an artificial eardrum using silk protein and a method of fabricating the same. The artificial eardrum is fabricated in the form of a silk membrane by desalinating and drying silk protein (or silk fibroin) or a silk protein complex solution obtained after removal of sericin from a silkworm cocoon or silk fiber. Thus, regeneration of an eardrum perforated due to disease or a sudden accident is stimulated, a boundary of the regenerated eardrum is clean and biocompatibility and transparency are increased. In addition, the artificial eardrum may be fabricated using the silk protein or silk protein complex solution obtained from a silkworm cocoon alone or mixed with collagen, alginic acid, PEG or pluronic 127.

Abstract: The present invention provides bee venom which can decrease expression levels of sclerotic factors, inflammatory factors and vascular adhesion factors associated with atherosclerosis, and a pharmaceutical composition comprising the bee venom as an active ingredient for the treatment of the atherosclerosis. When the bee venom was administered to laboratory animal models of atherosclerosis, the total cholesterol and neutral lipid were decreased, high-density cholesterol was maintained or even increased, the expression levels of TNF-? and IL-? as inflammation-associated cytokines were decreased in the blood, the expression levels of fibrosis-associated cytokines and vascular adhesion factors were decreased in the main artery and the heart, the plaque deposition generally caused by the atherosclerosis was decreased, and the expression levels of intercellular adhesion molecules (ICAM) and vascular cell adhesion molecules (VCAM), TGF-?1 and fibronectin as fibrosis-related cytokines were decreased.