Abstract: The present disclosure relates to bisphenyl compounds that are useful for inhibiting the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.

Abstract: The present invention relates to a pharmaceutical composition for promoting fertilization comprising cyclic ADP-ribose or its derivative, CD38 and to a method of promoting fertilization by promoting the synthesis of cyclic ADP-ribose to increase sperm motility. Also, the present invention relates to a pharmaceutical composition for contraception and a method for inhibiting fertilization, which can inhibit the expression or function of cyclic ADP-ribose to reduce sperm motility, thereby inhibiting fertilization.

Abstract: The administration of nicotinic acid adenine dinucleotide phosphate (NAADP) or a pharmaceutically acceptable salt thereof to a host in need thereof for the treatment of type-2 diabetes has been disclosed.

Abstract: The present disclosure relates to bisphenyl compounds that are useful for inhibiting the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.

Abstract: The present disclosure relates to bisphenyl compounds that are useful for inhibit the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.

Abstract: Nicotinic acid adenine dinucleotide phosphate and a pharmaceutically acceptable derivative thereof are useful for the treatment of type-2 diabetes.

Abstract: Disclosed is a tablet liquid crystal display device which senses light applied from a light irradiating device to receive an input signal applied from an exterior.

Abstract: A metal fiber media exhibiting superior durability, mechanical strength, and heat transfer efficiency, a filter for an exhaust gas purifier using the same as a filter member, and a method for manufacturing the filter are disclosed. The metal filter media includes a metal fiber mat made of longitudinally-aligned metal fiber yarns each including a bundle of 20 to 500 uniformly-oriented metal fibers and having a length of 0.45 to 0.6 m per 1 g, and a torsion of 1 to 9 turns/m such that the metal fiber mat has a porosity of 30 to 95%, and supports respectively attached to upper and lower surfaces of the metal fiber mat, the supports having a porosity of 5 to 95%. Since the metal fiber media exhibits excellent durability and mechanical strength, no crack is generated in the metal fiber medial due to external impact. Accordingly, there is no possibility of damage. Since the metal fiber media has excellent heat transfer efficiency, uniform heat transfer is achieved during regeneration of the filter.

Abstract: The present invention provides the use of L-2-oxothiazolidine-4-carboxylic acid for the treatment of type 2 diabetes(NIDDM; non-insulin dependent diabetes mellitus). The present invention also provides the pharmaceutical composition containing the chemical L-2-oxothiazolidine-4-carboxylic acid as an active agent for the treatment of type 2 diabetes and the method for the treatment of type 2 diabetes comprising administering to a mammal having the same disease.

Abstract: Disclosed are a thin film transistor-liquid crystal display(TFT-LCD) improving aperture ratio and having increased storage capacitance, and a manufacturing method of the same. The TFT-LCD comprises: a glass substrate; gate bus lines arranged parallel each other on the glass substrate; data bus lines disposed perpendicular to the gate bus lines thereby defining pixel region; a thin film transistor formed adjacent to each intersection of the gate bus line and the data bus line; a transparent pixel electrode being contacted with the thin film transistor and disposed at each pixel region; a transparent storage electrode formed at a bottom of the transparent pixel electrode, wherein the transparent storage electrode forms a storage capacitance together with the pixel electrode; and a common electrode line for transmitting common signal to the storage electrode.