Patents by Inventor Kwang-Poo Chang

Kwang-Poo Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunotherapy of canine leishmaniasis
    Patent number: 11219677
    Abstract: The present invention provides a method for treating canine leishmaniasis by immunotherapy.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: January 11, 2022
    Inventors: Kwang-Poo Chang, Laura Manna, Raffaele Corso, Bala K. Kolli
  • IMMUNOTHERAPY OF SOLID TUMORS BY VACCINATION WITH TRANSGENIC LEISHMANIA EXPRESSING CANCER VACCINES AND WITH RECOMBINANT VACCINES WITH LEISHMANIA AS ADJUVANTS
    Publication number: 20200376100
    Abstract: Disclosed herein are methods of vaccination against cancer by providing a sample of a photo-inactivated Leishmania optionally transgenically modified to express a cancer antigen such as alpha-enolase; optionally providing an effective amount of an alpha-enolase; and delivering an effective amount of the sample and/or the alpha-enolase to a patient in need thereof.
    Type: Application
    Filed: May 29, 2020
    Publication date: December 3, 2020
    Inventors: Kwang-Poo Chang, Bala K. Kolli
  • IMMUNOTHERAPY OF CANINE LEISHMANIASIS
    Publication number: 20180318408
    Abstract: The present invention provides a method for treating canine leishmaniasis by immunotherapy.
    Type: Application
    Filed: May 3, 2018
    Publication date: November 8, 2018
    Inventors: Kwang-Poo CHANG, Laura MANNA, Raffaele CORSO, Bala K. KOLLI
  • Photodynamic insecticides
    Patent number: 10070648
    Abstract: Disclosed herein are photodynamic insecticide methods and compositions for the control or reduction of insect populations comprising the use of photosensitizer compounds in combination with light.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: September 11, 2018
    Assignees: Rosalind Franklin University of Medicine and Science, National Taiwan University
    Inventors: Kwang Poo Chang, Bala Krishna Kolli, Shin-Hong Shiao
  • Photodynamic Insecticides
    Publication number: 20170295793
    Abstract: Disclosed herein are photodynamic insecticide methods and compositions for the control or reduction of insect populations comprising the use of photosensitizer compounds in combination with light.
    Type: Application
    Filed: April 10, 2017
    Publication date: October 19, 2017
    Inventors: Kwang Poo Chang, Bala Krishna Kolli, Shin-Hong Shiao
  • PHOTOSENSITIZED TRYPANOSOMATIDS AND VACCINE COMPOSITIONS THEREOF
    Publication number: 20170042989
    Abstract: Disclosed herein are methods and compositions for the delivery of polypeptides, including vaccine candidate polypeptides, into mammalian cells comprising the use of photosensitized trypanosomatid organisms. Also disclosed are methods of treatment of trypanosomatid infections comprising administering phthalocyanine compounds or phthalocyanine-treated trypanosomatid microorganisms as vaccines, as well as and polypeptide delivery vectors comprising phthalocyanine-treated trypanosomatid microorganisms.
    Type: Application
    Filed: August 11, 2016
    Publication date: February 16, 2017
    Inventors: Kwang Poo Chang, Bala Kolli, Dennis K.P. Ng
  • Leishmania-based carrier for vaccine delivery
    Patent number: 9327017
    Abstract: The present invention provides a composition for delivering a protein vaccination candidate to a mammalian subject having a Leishmania transfected for expressing a cDNA sequence for encoding the protein vaccination candidate, and the Leishmania containing a photosensitizer.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: May 3, 2016
    Assignee: Rosalind Franklin University of Medicine and Science
    Inventors: Kwang-Poo Chang, Sujoy Dutta
  • LEISHMANIA-BASED CARRIER FOR VACCINE DELIVERY
    Publication number: 20120288524
    Abstract: The present invention provides a composition for delivering a protein vaccination candidate to a mammalian subject having a Leishmania transfected for expressing a cDNA sequence for encoding the protein vaccination candidate, and the Leishmania containing a photosensitizer.
    Type: Application
    Filed: May 10, 2012
    Publication date: November 15, 2012
    Applicant: ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE
    Inventors: Kwang-Poo CHANG, Sujoy DUTTA
  • as carriers for the delivery of proteins and peptides
    Patent number: 7261887
    Abstract: Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. The agents are delivered by mutant trypanosomatid protozoa that have been genetically manipulated to code for such protein or peptide agents. The mutant protozoa additionally lack certain enzymes within the heme biosynthetic pathway, making the mutants susceptible to porphyria and eventual lysis.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: August 28, 2007
    Assignee: Rosalind Franklin University of Medicine and Science
    Inventors: Kwang-Poo Chang, Shigeru Sassa, Jerome F. Sah, Hiroya Ito, Bala Krishna Kolli, Daniel A. Peterson
  • Suicidal mutant vaccine
    Patent number: 7238347
    Abstract: The present invention discloses the use of a mutant Leishmania as a suicidal vaccine wherein the mutant Leishmania is responsive to external signals to become porphyric and commit suicidal cytolysis. The mutant can be selected from natural Leishmania species or constructed by genetic engineering.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: July 3, 2007
    Assignee: Rosalind Franklin University of Medicine and Science
    Inventors: Kwang-Poo Chang, Bala Krishna Kolli, Shigeru Sassa
  • Suicidal mutant leishmania vaccine
    Publication number: 20060018888
    Abstract: The present invention discloses the use of a mutant Leishmania as a suicidal vaccine wherein the mutant Leishmania is responsive to external signals to become porphyric and commit suicidal cytolysis. The mutant can be selected from natural Leishmania species or constructed by genetic engineering.
    Type: Application
    Filed: March 28, 2005
    Publication date: January 26, 2006
    Inventors: Kwang-Poo Chang, Bala Kolli, Shigeru Sassa
  • Biological carriers for the delivery of proteins or peptides
    Publication number: 20040092467
    Abstract: Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. The agents are delivered by mutant trypanosomatid protozoa that have been genetically manipulated to code for such protein or peptide agents. The mutant protozoa additionally lack certain enzymes within the heme biosynthetic pathway, making the mutants susceptible to porphyria and eventual lysis.
    Type: Application
    Filed: November 12, 2002
    Publication date: May 13, 2004
    Inventors: Kwang-Poo Chang, Shigeru Sassa, Jerome F. Sah, Hiroya Ito, Bala Krishna Kolli, Daniel A. Peterson