Patents by Inventor Kwang-Seuk Ko

Kwang-Seuk Ko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Colorimetric monitoring of reactions in solution and solid phase automated and manual systems
    Patent number: 7842511
    Abstract: The present invention relates to the a new protecting group, 4-(O-nitrophthalimido)butyric acid (NPB) that may be attached to a monomer unit during oligosaccharide synthesis such that upon cleavage of this molecule, the solution turns orange. The orange color allows the simple colorimetric monitoring of the completion of the cleavage reaction and, upon collection of the colored fraction, quantification of the amount of the monomer unit that was successfully coupled to the solid phase.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: November 30, 2010
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Nicola Lucia Pohl, Kwang-Seuk Ko
  • More stable analog of isopropyl thiogalactoside for induction of protein expression
    Patent number: 7141394
    Abstract: A novel C-glycoside of isopropylthiogalactoside (IPTG), isobutyl-C-galactoside (IBCG), is described. IBCG may be used as an IPTG substitute for increased induction of protein expression of plasmid-based genes for the production of recombinant proteins under the control of the lac promoter. IBCG offers the advantage over IPTG of being stable at ambient temperature.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: November 28, 2006
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Nicola Lucia Pohl, Kwang-Seuk Ko
  • Fluorous-based microarrays
    Publication number: 20060199211
    Abstract: A novel means of arraying fluorous tagged probes is disclosed. The method involves fluorous-tagging probes and attaching the same to a substrate having a fluorous surface. Target molecules are then identified and analyzed following attachment to the microarray.
    Type: Application
    Filed: March 3, 2006
    Publication date: September 7, 2006
    Inventors: Nicola Pohl, Kwang-Seuk Ko
  • More stable analog of isopropylthiogalactoside for induction of protein expression
    Publication number: 20040224390
    Abstract: A novel C-glycoside of isopropylthiogalactoside (IPTG), isobutyl-C-galactoside (IBCG), is described. IBCG may be used as an IPTG substitute for increased induction of protein expression of plasmid-based genes for the production of recombinant proteins under the control of the lac promoter. IBCG offers the advantage over IPTG of being stable at ambient temperature.
    Type: Application
    Filed: April 19, 2004
    Publication date: November 11, 2004
    Applicant: IOWA STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Nicola Lucia Pohl, Kwang-Seuk Ko