Abstract: A method of identifying a cell state regulation path is described, including the steps of setting a state of each node constituting an expanded network generated from a Boolean network corresponding to a biomolecular network of a particular cell to a value of a predetermined given initial state of the Boolean network; selecting a test subject node from diff-FBLs having complementary states in the initial state of the Boolean network and in a given target state, among the Boolean network FBLs, and perturbing the selected test subject node by computer simulation; testing whether the perturbation changes the values of all nodes in the diff-FBLs from initial state values to target state values; and, if the test subject node passes the test, determining that the test subject node is a master regulator, which must be controlled to transition the Boolean network from the initial state to the target state.

Abstract: The present invention relates to a composition for inhibiting metastasis and enhancing anticancer drug sensitivity, the composition removing, from cancer cells, stem cell properties and heterogeneity acquired by epithelial-to-mesenchymal transition (EMT), thereby being capable of inducing the cancer cells into a phenotype which has regained responsiveness to a chemotherapeutic agent. A combination of a p53 activator, a SMAD4 inhibitor and an ERK inhibitor of the present invention enables a mesenchymal cell phenotype to return to an epithelial cell phenotype, and also enables the ability of cancer cells to metastasize to be inhibited by overcoming the high plasticity and drug resistance of the cancer cells, and thus may be widely used in the field of cancer treatment.

Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of cancer, comprising a DEAD-box helicase 54 (DDX54) inhibitor and a cancer immunotherapy agent, and to a combination therapy of cancer immunotherapy. The DDX54 inhibitor according to the present invention can enhance the efficacy of cancer immunotherapy when used in combination with a cancer immunotherapy agent, and the composition containing the DDX54 inhibitor and a cancer immunotherapy agent inhibits proliferation of cancer, which is a key characteristic thereof, and simultaneously inhibits a signal transduction pathway known as an immune evasion mechanism, and thus may be provided for the prevention or treatment of cancer.

Abstract: A method for determining suitability of a drug administered for cell state transition, including: acquiring baseline states of actual cells, perturbed states of the actual cells to which the drug is administered, an initial cell state of a patient, and a target cell state representing the normal state of the patient's cells; encoding the baseline states, the perturbed states, the initial cell state, and the target cell state to generate latent baseline states, latent perturbed states, a latent initial cell state, and a latent target cell state, respectively; calculating a representative distance vector indicating distance between the latent baseline states and the latent perturbed states, and calculating a reference distance vector, which is the distance vector between the latent initial cell state and the latent target cell state; and determining suitability of the drug based on the degree of similarity between the representative distance vector and the reference distance vector.

Abstract: The present invention relates to a composition comprising a SETMAR inhibitor for preventing or treating cancer. It has been identified that if SETMAR is inhibited in cancer cells, carcinogenesis reversion, which is the differentiation of cancer cells into normal cells, is successfully achieved, and thus, unlike conventional anticancer agents that simply induce cancer cell death, the present invention can be effectively used as a treatment method excluding the side effect of normal cell death that can occur during anticancer treatment, and converting cancer cells into normal cells.

Abstract: A device configured for coupling a resonator to a vehicle wheel, may include an annular first strap assembled with an external circumferential surface of the wheel rim and fixing positions of resonators disposed on the external circumferential surface of the wheel rim; and an annular second strap surrounding second flanges formed at second edge portions of the resonators based on an axial direction of the wheel rim and pressurizing the second flange toward the external circumferential surface of the wheel rim after first flanges, which are formed on second edge portions of the resonators based on an axial direction of the wheel rim, are inserted between the first strap and the external circumferential surface of the wheel rim.

Abstract: There is disclosed a method for determining a cancer treatment candidate drug including generating, by a simulation device, a plurality of specific perturbation networks by applying mutation information for a first cancer cell line to each of a plurality of drug responsive networks for a plurality of drugs, and selecting a plurality of candidate drugs from among the plurality of drugs based on a plurality of cell death probabilities for the first cancer cell line output by the plurality of specific perturbation networks.

Abstract: A device configured for coupling a resonator to a vehicle wheel, may include an annular first strap assembled with an external circumferential surface of the wheel rim and fixing positions of resonators disposed on the external circumferential surface of the wheel rim; and an annular second strap surrounding second flanges formed at second edge portions of the resonators based on an axial direction of the wheel rim and pressurizing the second flange toward the external circumferential surface of the wheel rim after first flanges, which are formed on second edge portions of the resonators based on an axial direction of the wheel rim, are inserted between the first strap and the external circumferential surface of the wheel rim

Abstract: Provided is a method of predicting a condition of a patient, including decomposing an input matrix to produce a residual matrix, the input matrix representing patients and expression levels of genes of the patients, training a classifier by using health condition values the patients as learning criteria and inputting the residual matrix into the classifier, and obtaining a value for predicting a health condition of a first patient, by inputting a first input matrix including the expression levels of genes of the first patient into the classifier, the first residual matrix being a residual matrix obtained from the first input matrix by using the predetermined algorithm.

Abstract: An electronic device including a flexible display and a method thereof are disclosed herein. The electronic device may include the flexible display and a processor. The processor implements the method, including controlling the flexible display to divide a display area into a first area and a second area, controlling the flexible display to display a first graphic element related to a first application in the first area, and a second graphic element related to controlling the first application in the second area, and controlling the first application responsive to detecting an input to the second graphic element.

Abstract: A method for operating a communication device is disclosed. One embodiment includes the steps of: generating an intermediary key corresponding to peer to peer (P2P) communication between a client and a counterpart client; transmitting the intermediary key to the counterpart client; obtaining an intermediary path corresponding to the intermediary key; receiving the data through the intermediary path from the client that did not receive an acknowledgement for data transmitted to the counterpart client because of a change of a network address of the counterpart client; and transmitting the data to the counterpart client if the counterpart client accesses the changed network address by using the intermediary key.

Abstract: An electronic device is provided. The electronic device includes a display and a processor operatively connected to the display and configured to control the display to display a window related to context recognition on the display according to a predefined first layout corresponding to a first event related to screen splitting and control the display to display at least two windows split with respect to a folded portion of the display according to a predefined second layout corresponding to a second event related to the screen splitting.

Abstract: An electronic device is provided. The electronic device includes a communication module configured to communicate with an external device, an input module configured to receive an input, and a processor configured to send a request for following a second user to a content providing server, if the request for following the second user is received from a first user and to receive at least one content, to which the second user subscribes, from the content providing server.

Abstract: A system for manufacturing a semiconductor device includes a main system controller, a sub-system controller, and a process module. The main system controller provides a process recipe for manufacturing the semiconductor device and step identification information indicating one of a plurality of operations in the process recipe. The sub-system controller sets a process control variable based on the process recipe and the step identification information received from the main system controller.

Abstract: A method for operating a communication device is disclosed. One embodiment includes the steps of: generating an intermediary key corresponding to peer to peer (P2P) communication between a client and a counterpart client; transmitting the intermediary key to the counterpart client; obtaining an intermediary path corresponding to the intermediary key; receiving the data through the intermediary path from the client that did not receive an acknowledgement for data transmitted to the counterpart client because of a change of a network address of the counterpart client; and transmitting the data to the counterpart client if the counterpart client accesses the changed network address by using the intermediary key.

Abstract: The present disclosure provides a neuronal resonance-magnetic resonance imaging (NR-MRI) method and technology for measuring a difference between a resting state and a state of providing external stimuli with respect to various frequency bands by using the NR-MRI scheme through frequency band selection filter characteristic mapping of neurons. In addition, the present disclosure provides technology for revealing a frequency selective communication mechanism between brain regions on the basis of systems biology researches for the frequency selective communication mechanism between the brain regions as well as technology useful for completing proof-of-concept and a frequency selective communication map between the entire brain regions.

Abstract: An electric device, which includes a first switch-unit providing a first internal circuit signal, a first delay circuit unit outputting a second internal circuit signal which is generated by delaying the first internal circuit signal, a first AND logic outputting a first repair-signal generated by a logical AND operation between the first internal circuit signal and the second internal circuit signal, a first OR logic outputting a second repair-signal generated by a logical OR operation between the first internal circuit signal and the second internal circuit signal, and a second switch-unit selecting one of the first repair-signal and the second repair-signal according to a third internal circuit signal generated by an operation including a logical AND operation between the first repair-signal and the second repair-signal and providing the selected one as an output signal through an output terminal, is released.

Abstract: An electric device, which includes a first switch-unit providing a first internal circuit signal, a first delay circuit unit outputting a second internal circuit signal which is generated by delaying the first internal circuit signal, a first AND logic outputting a first repair-signal generated by a logical AND operation between the first internal circuit signal and the second internal circuit signal, a first OR logic outputting a second repair-signal generated by a logical OR operation between the first internal circuit signal and the second internal circuit signal, and a second switch-unit selecting one of the first repair-signal and the second repair-signal according to a third internal circuit signal generated by an operation including a logical AND operation between the first repair-signal and the second repair-signal and providing the selected one as an output signal through an output terminal, is released.

Abstract: A drug efficiency calculation method comprises generating information regarding a perturbation state transition diagram which is a state transition diagram of a specific perturbation network generated by applying a perturbation corresponding to a specific drug to a specific network generated by mapping the gene mutation information of a cancer-cell to a nominal network, and calculating a score regarding the efficiency of the drug on the basis of the size of one or more basins of the perturbation state transition diagram.

Abstract: A method of segmenting input speech signal into plurality of frames for speech recognition is disclosed. The method includes extracting a low frequency signal from the speech signal, and segmenting the speech signal into a plurality of time-intervals according to a plurality of instantaneous phase-sections of the low frequency signal.