Patents by Inventor Kwok Fai So
Kwok Fai So has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11839694Abstract: Compositions that include nanoscale structured materials or precursors thereof (e.g., self: assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.Type: GrantFiled: April 5, 2016Date of Patent: December 12, 2023Assignees: Massachusetts Institute of Technology, Versitech LimitedInventors: Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald E. Schneider, Kwok-Fai So, David K. C. Tay, Shuguang Zhang
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Patent number: 10137166Abstract: Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. In one embodiment, the formulation is provided as a dry or lyophilized powder. In another embodiment, the material is provided in water. In another embodiment, the material is provided in combination with an oil and forms a laminate.Type: GrantFiled: November 2, 2016Date of Patent: November 27, 2018Assignees: Massachusetts Institute of Technology, Versitech LimitedInventors: Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald E. Schneider, Kwok-Fai So, David K. C. Tay
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Publication number: 20170143788Abstract: Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract.Type: ApplicationFiled: November 2, 2016Publication date: May 25, 2017Applicants: Massachusetts Institute of Technology, Versitech LimitedInventors: Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald E. Schneider, Kwok-Fai So, David K.C. Tay
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Patent number: 9511113Abstract: Method are described for inhibiting movement of a bodily fluid and/or contaminants on or in an animal comprising administering to the animal self-assembling peptidomimetics, including ?-peptides, ?-peptides, ?-peptides, and/or ?-peptides.Type: GrantFiled: June 23, 2015Date of Patent: December 6, 2016Assignees: Massachusetts Institute of Technology, Versitech LimitedInventors: Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald E. Schneider, Kwok-Fai So, David K. C. Tay
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Publication number: 20160296660Abstract: Compositions that include nanoscale structured materials or precursors thereof (e.g., self: assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.Type: ApplicationFiled: April 5, 2016Publication date: October 13, 2016Applicants: Massachusetts Institute of Technology, Versitech LimitedInventors: Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald E. Schneider, Kwok-Fai So, David K.C. Tay, Shuguang Zhang
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Patent number: 9364513Abstract: Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.Type: GrantFiled: August 27, 2008Date of Patent: June 14, 2016Assignees: Maasachusetts Institute of Technology, Versitech LimitedInventors: Rutledge Ellis-Behnke, Shuguang Zhang, Gerald Schneider, Kwok-Fai So, David Tay, Yu-Xiang Liang
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Patent number: 9327010Abstract: Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.Type: GrantFiled: April 25, 2006Date of Patent: May 3, 2016Assignees: Massachusetts Institute of Technology, Versitech LimitedInventors: Rutledge Ellis-Behnke, Shuguang Zhang, Gerald Schneider, Kwok-Fai So, David Tay, Yu-Xiang Liang
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Publication number: 20150328279Abstract: Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract.Type: ApplicationFiled: June 23, 2015Publication date: November 19, 2015Applicants: Massachusetts Institute of Technology, Versitech LimitedInventors: Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald E. Schneider, Kwok-Fai So, David K.C. Tay
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Patent number: 9084837Abstract: Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid.Type: GrantFiled: April 25, 2007Date of Patent: July 21, 2015Assignees: Massachusetts Institute of Technology, Versitech Limited The University of Hong KongInventors: Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald E. Schneider, Kwok-Fai So, David Tay
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Patent number: 8651406Abstract: A pepper grinder has a body, a grinding mechanism, and a drive mechanism for operating the grinding mechanism by causing relative movement between two grinding members. The drive mechanism has a lever for reciprocating pivotal movement in opposite directions to produce a driving force, a first ratchet arranged to transmit the driving force from the lever, upon pivoting of the lever in the first direction, causing relative movement between the grinding members in a third direction to grind pepper, and a second ratchet arranged to transmit the driving force from the lever, upon pivoting of the lever in the second direction, causing relative movement between the grinding members in the third direction to grind pepper. Upon reciprocating pivoting of the lever in the opposite directions, the first and second ratchets alternate in transmitting the driving force from the lever to the grinding mechanism.Type: GrantFiled: July 11, 2011Date of Patent: February 18, 2014Assignee: Ki Mee Kitchenware LimitedInventor: Kwok Fai So
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Publication number: 20130015279Abstract: A pepper grinder has a body, a grinding mechanism, and a drive mechanism for operating the grinding mechanism by causing relative movement between two grinding members. The drive mechanism has a lever for reciprocating pivotal movement in opposite directions to produce a driving force, a first ratchet arranged to transmit the driving force from the lever, upon pivoting of the lever in the first direction, causing relative movement between the grinding members in a third direction to grind pepper, and a second ratchet arranged to transmit the driving force from the lever, upon pivoting of the lever in the second direction, causing relative movement between the grinding members in the third direction to grind pepper. Upon reciprocating pivoting of the lever in the opposite directions, the first and second ratchets alternate in transmitting the driving force from the lever to the grinding mechanism.Type: ApplicationFiled: July 11, 2011Publication date: January 17, 2013Applicant: KI MEE KITCHENWARE LIMITEDInventor: Kwok Fai So
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Patent number: 7931918Abstract: A method of manufacture of ECM microparticles incorporating bioactive molecules for drug delivery has been developed, using a modified emulsification method or a water-in-oil-phase-separation method. The microspheres are photochemically crosslinked to control the release of the bioactive molecules for better drug delivery usage without compromising the biocompatibility of the crosslinked structures. The method uses mild fabrication conditions and simple processes, no toxic chemical crosslinking reagent, which may cause cytotoxicity and calcification after implantation, no organic solvents, which may reduce drug availability and bioactivity, and no vigorous stirring action, which may fragmentize material with poor shape and mechanical stability and thus destabilize the emulsion. The resulting microparticles or microspheres are of controlled size, controlled release, highly biocompatible, and useful for drug delivery as well as cell culture.Type: GrantFiled: July 2, 2008Date of Patent: April 26, 2011Assignee: The University of Hong KongInventors: Barbara Pui Chan, Ming Cheuk Chan, Kwok Fai So
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Publication number: 20090111734Abstract: Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.Type: ApplicationFiled: August 27, 2008Publication date: April 30, 2009Applicants: Massachusetts Institute of Technology, Versitech LimitedInventors: Rutledge Ellis-Behnke, Shuguang Zhang, Gerald Schneider, Kwok-Fai So, David Tay, Yu-Xiang Liang
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Publication number: 20090053229Abstract: The invention provides methods for treating conditions of the eye involving death or degeneration of retinal ganglion cells, including glaucoma, by the administration of Nogo receptor-1 antagonists.Type: ApplicationFiled: May 12, 2006Publication date: February 26, 2009Inventors: Daniel H.S. Lee, Dinah W.Y. Sah, Kwok Fai So, Wutian Wu
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Publication number: 20080317866Abstract: A method of manufacture of ECM microparticles incorporating bioactive molecules for drug delivery has been developed, using a modified emulsification method or a water-in-oil-phase-separation method. The microspheres are photochemically crosslinked to control the release of the bioactive molecules for better drug delivery usage without compromising the biocompatibility of the crosslinked structures. The method uses mild fabrication conditions and simple processes, no toxic chemical crosslinking reagent, which may cause cytotoxicity and calcification after implantation, no organic solvents, which may reduce drug availability and bioactivity, and no vigorous stirring action, which may fragmentize material with poor shape and mechanical stability and thus destabilize the emulsion. The resulting microparticles or microspheres are of controlled size, controlled release, highly biocompatible, and useful for drug delivery as well as cell culture.Type: ApplicationFiled: July 2, 2008Publication date: December 25, 2008Inventors: Barbara Pui Chan, Cheuk Ming Chan, Kwok Fai So
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Patent number: 7468434Abstract: This invention provides a method for treating an eye disease in a patient comprising: providing a photosensitive prodrug that releases upon exposure to light an active ingredient to treat the eye disease; administering the prodrug in a pharmaceutically accepted vehicle to the subject, and exposing the eye of the subject to an external light source to cause the prodrug to release the active ingredient. This invention also provides a composition for the treatment of glaucoma, comprising a compound containing a lithium ion-chelated in a crown ether- or aza-crown ether-containing chromene or diazene derivative and a pharmaceutically acceptable carrier.Type: GrantFiled: December 21, 2005Date of Patent: December 23, 2008Assignee: The University of Hong KongInventors: Paul Michel Georges Vanhoutte, Chi-Ming Che, Kwok-Fai So, Iona Hiu Tung Sham
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Patent number: 7393437Abstract: A method for producing collagen-based scaffolds with improved characteristics, which broadens the usage of collagen in tissue engineering and the products so produced are described. The method comprises reconstitution of three-dimensional collagen matrices from collagen monomer solution and crosslinking the matrix with a light source in the presence of a photosensitizing reagent. The crosslinked products can be in any shape and form and used in the dry or wet state, for applications including but not limited to tissue engineering and controlled drug delivery.Type: GrantFiled: September 14, 2005Date of Patent: July 1, 2008Assignee: The University of Hong KongInventors: Barbara P Chan, Kwok Fai So
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Publication number: 20080091233Abstract: Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract.Type: ApplicationFiled: April 25, 2007Publication date: April 17, 2008Applicant: Massachusetts Institute of TechnologyInventors: Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald Schneider, Kwok-Fai So, David Tay
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Publication number: 20070298127Abstract: This invention provides a method for treating an eye disease in a patient comprising: providing a photosensitive prodrug that releases upon exposure to light an active ingredient to treat the eye disease; administering the prodrug in a pharmaceutically accepted vehicle to the subject, and exposing the eye of the subject to an external light source to cause the prodrug to release the active ingredient. This invention also provides a composition for the treatment of glaucoma, comprising a compound containing a lithium ion-chelated in a crown ether- or aza-crown ether-containing chromene or diazene derivative and a pharmaceutically acceptable carrier.Type: ApplicationFiled: December 21, 2005Publication date: December 27, 2007Inventors: Paul Vanhoutte, Chi-Ming Che, Kwok-Fai So, Iona Sham
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Publication number: 20070203062Abstract: Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.Type: ApplicationFiled: April 25, 2006Publication date: August 30, 2007Inventors: Rutledge Ellis-Behnke, Shuguang Zhang, Gerald Schneider, Kwok-Fai So, David Tay, Yu-Xiang Liang