Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, having utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for the preparation thereof, and use in medicine. There is particularly provided PROTACs which bind to a protein within the bromo- and Extra-terminal (BET) family of proteins, and especially to PROTACs including novel small molecule E3 ubiquitin ligase protein binding ligand compounds which selectively induce degradation of the BRD4 protein within the bromodomain of the BET family of proteins.

Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, having utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for the preparation thereof, and use in medicine. There is particularly provided PROTACs which bind to a protein within the bromo- and Extra-terminal (BET) family of proteins, and especially to PROTACs including novel small molecule E3 ubiquitin ligase protein binding ligand compounds which selectively induce degradation of the BRD4 protein within the bromodomain of the BET family of proteins.

Abstract: A method of selectively inhibiting a bromodomain in the presence of other bromodomains comprising introducing a functionally silent mutation into the bromodomain in the presence of other wild type bromodomains and selectively inhibiting the mutated bromodomain.

Abstract: A technique for end-to-end admission control of real-time packet flows is disclosed. In one embodiment, the technique may be realized as a method for end-to-end admission control of real-time packet flows in a network having a plurality of network elements. The method may include transmitting at least one probe packet from a first network element to a second network element via a network path, determining, at at least one intermediate network element on the network path, at least one flow rate associated with a plurality of packets, marking at least one predetermined bit in the at least one probe packet if the at least one flow rate is greater than a predetermined rate, and controlling an admission of additional packets into the network based at least in part on the marking of the at least one predetermined bit in the at least one probe packet.

Abstract: A technique for end-to-end admission control of real-time packet flows is disclosed. In one embodiment, the technique may be realized as a method for end-to-end admission control of real-time packet flows in a network having a plurality of network elements. The method may include transmitting at least one probe packet from a first network element to a second network element via a network path, determining, at at least one intermediate network element on the network path, at least one flow rate associated with a plurality of packets, marking at least one predetermined bit in the at least one probe packet if the at least one flow rate is greater than a predetermined rate, and controlling an admission of additional packets into the network based at least in part on the marking of the at least one predetermined bit in the at least one probe packet.

Abstract: A technique for end-to-end admission control of real-time packet flows is disclosed. In one embodiment, the technique may be realized as a method for end-to-end admission control of real-time packet flows in a network having a plurality of network elements. The method may include transmitting at least one probe packet from a first network element to a second network element via a network path, determining, at at least one intermediate network element on the network path, at least one flow rate associated with a plurality of packets, marking at least one predetermined bit in the at least one probe packet if the at least one flow rate is greater than a predetermined rate, and controlling an admission of additional packets into the network based at least in part on the marking of the at least one predetermined bit in the at least one probe packet.

Abstract: A technique for end-to-end admission control of real-time packet flows is disclosed. In one particular exemplary embodiment, the technique may be realized as a method for end-to-end admission control of real-time packet flows in a network having a plurality of network elements. The method may comprise transmitting at least one probe packet from a first network element to a second network element via a network path, determining, at least one intermediate network element on the network path, at least one flow rate associated with a plurality of packets, marking at least one predetermined bit in the at least one probe packet if the at least one flow rate is greater than a predetermined rate, and controlling an admission of additional packets into the network based at least in part on the marking of the at least one predetermined bit in the at least one probe packet.

Abstract: A method and apparatus for establishing communication (across a network) between a first network device and a second network device apply policy data received from a policy device (e.g., a policy server), thus offloading significant functionality from the policy device. Offloading such functionality reduces the processing required by the policy device, thus improving network performance. Such systems permit network access admission control in a scalable manner.