Patents by Inventor Kwok Kin CHENG

Kwok Kin CHENG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10179179
    Abstract: Provided herein is a nanoparticle comprising a metal core and a polymer shell coating the metal core useful as a magnetic resonance contrast agent.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: January 15, 2019
    Assignee: Nano and Advanced Materials Institute Limited
    Inventors: Kwok Kin Cheng, Sau Kuen Connie Kwok, Chun Hay Ko, Kevin Tsai, Chun Fai Ng
  • Patent number: 10076496
    Abstract: The present invention provides organic nanoparticles that include a molecule having a Log P value of about 3 or above, an amphiphilic diblock copolymer or a surfactant, and a pharmaceutically-acceptable hydrophilic polymer. The present invention also provides methods of making these nanoparticles, e.g., by flash nanoprecipitation, with control over particle size and surface properties. The methods of the present invention provide a means for co-precipitating a water-insoluble compound with an amphiphilic stabilizer within a few milliseconds. The nanoparticles of the present invention exhibit high drug loading, e.g., 50% w/w, and can be produced with a mean particle size less than 200 nm and with a narrow particle size distribution.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: September 18, 2018
    Assignee: The Chinese University of Hong Kong
    Inventors: Albert Hee Lum Chow, Shing Fung Chow, Xin Ran Zhang, Ka Yee Wan, Kwok Kin Cheng, Lawrence William Baum
  • Publication number: 20180236107
    Abstract: The present invention relates to a particle composition for use as a contrasting agent in medical imaging such as Magnetic Resonance Imaging (MRI), the particle composition comprising: a metal containing compound comprises at least one metal complexed with at least one metal chelating agent; wherein the metal chelating agent is adapted to bind to one or more protein molecules to thereby allow or enhance visibility of the protein molecules under the medical imaging. The present invention further relates to a diagnostic agent for use in magnetic resonance imaging (MRI) comprising the above described particle composition; and a method of preparing thereof.
    Type: Application
    Filed: February 20, 2017
    Publication date: August 23, 2018
    Inventors: Connie Sau-Kuen Kwok, Kwok Kin Cheng
  • Publication number: 20180236108
    Abstract: The present invention relates to a composition for use as a contrast agent in medical imaging. The composition comprises a metal ion containing compound comprises at least one metal ion adapted to bind with one or more metal ion chelating agents; wherein said one or more metal ion chelating agents comprise at least one first chelating agent adapted to target a region of interest being imaged, and at least one second chelating agent having at least one functional group adapted to dissociate in an aqueous medium to thereby allow or enhance contrast of the region of interest under the medical imaging. The present invention further relates to a diagnostic agent for use in amyloid (A?) protein detection under magnetic resonance imaging (MRI) comprising the above described composition; and a method of preparing thereof.
    Type: Application
    Filed: December 5, 2017
    Publication date: August 23, 2018
    Inventors: Connie Sau-Kuen Kwok, Kwok Kin Cheng
  • Publication number: 20180117185
    Abstract: Provided herein is a nanoparticle comprising a metal core and a polymer shell coating the metal core useful as a magnetic resonance contrast agent.
    Type: Application
    Filed: October 20, 2017
    Publication date: May 3, 2018
    Inventors: Kwok Kin CHENG, Sau Kuen Connie KWOK
  • Publication number: 20170196998
    Abstract: The disclosure herein relates to a novel nanoparticle that can cross the blood-brain barrier and form a bond with amyloid plaques and other related protein aggregates for detection by magnetic resonance imaging (MRI). The compositions, methods of making, and methods of use set forth herein also provide a non-invasive means for diagnosing Alzheimer's disease at an early stage.
    Type: Application
    Filed: January 12, 2016
    Publication date: July 13, 2017
    Inventors: Lawrence William BAUM, Hee Lum Albert CHOW, Kwok Kin CHENG