Abstract: The present disclosure provides a process of producing a dry powder coated pharmaceutical capsule. The method includes preparing a dry powder film forming polymer coating composition to be coated onto an outer surface of the capsules, a size of the particulate coating powder being in a range from about 1 nm to about 500 ?m. The capsules are placed into an interior of a rotatable housing and may be preheated. The dry powder coating composition is sprayed into the interior of the housing while the rotatable housing is rotating to produce a uniform coating of the dry powder coating composition on the outer surface of the capsules. The coated capsules are cured form a substantially uniform cured.

Abstract: The present disclosure provides powder coating compositions for pharmaceutical pellets which include one or more film forming polymers in powder form present in the composition in a range from about 1 to about 95% w/w. The compositions include one or more plasticizers in powder or liquid form present in the composition in quantity to lower the glass transition temperature of the coating composition to a temperature in a range from about 30 to 100° C. The compositions also include one or more one anti-static agents in powder or liquid form present in the composition in a range from about 0.1 to about 95% w/w as well as one or more flow enhancing agents in powder form present in the composition in a range from about 0.1 to about 25% w/w.

Abstract: The present disclosure provides a process of producing a dry powder coated pharmaceutical capsule. The method includes preparing a dry powder film forming polymer coating composition to be coated onto an outer surface of the capsules, a size of the particulate coating powder being in a range from about 1 nm to about 500 ?m. The capsules are placed into an interior of a rotatable housing and may be preheated. The dry powder coating composition is sprayed into the interior of the housing while the rotatable housing is rotating to produce a uniform coating of the dry powder coating composition on the outer surface of the capsules. The coated capsules are cured form a substantially uniform cured.

Abstract: The present disclosure provides a process of producing a dry powder coated solid, oral administered pharmaceutical osmotic drug delivery system. The method includes preparing a dry powder film forming polymer coating composition to be coated onto an outer surface of the cores, a size of the coating powder being in a range from about 1 nm to about 500 ?m. The osmotic drug delivery cores are placed into an interior of a rotatable housing and the cores may be preheated. The dry powder coating composition is sprayed into the interior of the housing while the housing is rotating to produce a uniform coating of the dry powder coating composition on the outer surface of the cores. The coated cores are cured form a substantially uniform cured film after which one or more orifices are produced through the uniform cured film to expose the outer surface of the cores at a position of each of the one or more orifices.

Abstract: The present disclosure provides a process of producing a dry powder coated pharmaceutical capsule. The method includes preparing a dry powder film forming polymer coating composition to be coated onto an outer surface of the capsules, a size of the particulate coating powder being in a range from about 1 nm to about 500 ?m. The capsules are placed into an interior of a rotatable housing and may be preheated. The dry powder coating composition is sprayed into the interior of the housing while the rotatable housing is rotating to produce a uniform coating of the dry powder coating composition on the outer surface of the capsules. The coated capsules are cured form a substantially uniform cured.

Abstract: The present disclosure provides powder coating compositions for pharmaceutical pellets which include one or more film forming polymers in powder form present in the composition in a range from about 1 to about 95% w/w. The compositions include one or more plasticizers in powder or liquid form present in the composition in quantity to lower the glass transition temperature of the coating composition to a temperature in a range from about 30 to 100° C. The compositions also include one or more one anti-static agents in powder or liquid form present in the composition in a range from about 0.1 to about 95% w/w as well as one or more flow enhancing agents in powder form present in the composition in a range from about 0.1 to about 25% w/w.

Abstract: A method for predicting flow properties of one or more materials proposed for processing in a system that requires good flow properties to operate successfully includes identifying a plurality of key flow points along a system, for each key flow point so identified, characterizing the type of flow occurring at that key flow point, for each key flow point, selecting a flow test relevant for modeling the type of flow occurring at that key flow point, providing a plurality of material samples wherein each material sample has a different composition, blend and/or concentration of ingredients, for each key flow point, modeling the type of flow occuring at that key flow point by conducting the flow test selected for that key flow point on each material sample to produce a plurality of test result values, wherein each test result value is a function of one of the flow tests conducted and of the material sample tested by that flow test, and ranking each material sample based on a calculated average of the test result

Abstract: A method for predicting flow properties of a material such as a pharmaceutical powder, which material is proposed for processing in a system that requires good flow properties for its successful operation. The method includes identifying key flow points along the system and, for each key flow point so identified, characterizing the type of flow occurring at that key flow point and selecting a flow test relevant for modeling the type of flow occurring at that key flow point. A plurality of material samples are selected as being candidates for processing in the system, wherein each material sample has a different composition, blend or concentration of ingredients. For each key flow point and for each material sample, the flow type characterizing the key flow point is modeled by conducting the specific flow test selected for that key flow point.