Abstract: Disclosed are 2,8-diazaspiro[4.5]decane compounds, including (pyrido[3,4-d]pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane compounds, (2,6-naphthyridin-1-yl)-2,8-diazaspiro[4.5]decane compounds, and (1,7-naphthyridin-4-yl)-2,8-diazaspiro[4.5]decane compounds, that are inhibitors of LATS1/2, compositions containing these compounds, and methods for inhibiting LATS1/2 activity.

Abstract: An absorption vacuum dehumidification system includes a vacuum section, an absorber, a desorber, a photovoltaic energy supply, a heat exchanger, a condenser, and a desiccant solution. The vacuum section has a feed side and a permeate side and comprising a hydrophilic membrane that separates the feed side than the permeate side. The absorber is connected to the permeate side of the vacuum section. The desorber is connected to the absorber to form a desiccant solution cycle path between the absorber and the desorber. The photovoltaic energy supply configured to power a heat source that provides hot liquid into the desorber. The heat exchanger is connected to the desiccant solution cycle path. The condenser is connected to the desorber. The desiccant solution flows along the desiccant solution cycle path.

Abstract: The present invention belongs to the field of pharmaceutical formulations, and relates to a composition comprising a derivative of a wild-type cell-penetrating peptide penetratin and a drug having positive charge under physiological pH conditions. The derivative of the wild-type cell-penetrating peptide penetratin is a lipophilic derivative designed by using the wild-type cell-penetrating peptide penetratin, and the molecule is positively charged as a whole under physiological pH conditions. Said composition of the present invention, as an ocular drug delivery system, can enable a drug positively charged under physiological pH conditions to be absorbed to the posterior segment of the eye by means of eye dropping, thereby providing a new route for achieving ocular delivery of a drug positively charged under physiological pH conditions.

Abstract: A network verification system uses general-purpose programming language to create network verification tests. A test orchestrator builds a model of the network only using data from the network verification test. An optimization testing manager creates symbolic packets for verification tests using assertions based on a packet library embedded into the testing manager and the general-purpose programming language.

Abstract: The present invention provides a heat-driven adsorption vacuum dehumidification system including a vapor adsorption apparatus having a water permeable hydrophilic membrane separating the apparatus into at least a feed section and a low-pressure or vacuum section (evaporator), and providing a water vapor pressure difference to extract moisture from the air flowing through the apparatus into the evaporator, followed by adsorption in an adsorption chamber, and subsequently desorbed when acted as a desorption chamber to form water vapor which is condensed in a condenser. Adsorption and desorption chambers inter-change periodically to form a complete system cycle. Heating of chamber/compartment can be from waste heat or a renewable source in the absence of any electricity supplied externally. Related method for using a heat-driven adsorption vacuum dehumidification system to remove moisture from the air is also provided.

Abstract: The present disclosure relates to a heat sink pedestal including a composite material. The composite material may include at least one layer of a thermally conductive primary material and at least one layer of a thermally conductive secondary material. The composite material may include a conductivity ratio of lateral thermal conductivity (Kz) to planar thermal conductivity (Kx, Ky) of the composite material of at least 0. The heat sink pedestal may be conformable to a shape of a semiconductor chip.

Abstract: The present disclosure relates to a semiconductor package that may include a substrate, at least one die coupled to the substrate, and a stiffener coupled to the substrate, wherein the stiffener may include a stiffener frame, wherein the stiffener frame at least partially surrounds the at least one die. The stiffener may include at least one resilient member extending from the stiffener frame towards the at least one die, and the at least one resilient member may include a distal end that extends at a height above the substrate.

Abstract: Systems and techniques for controlling a mobile robot. In an example, the system may include a processor and memory, including instructions, which when executed by the processor, cause the processor to determine a state of the mobile robot. The state of the mobile robot may be determined using at least one of: data provided by the mobile robot or data captured by one or more sensors proximate to or attached to the mobile robot. The system may determine a state of an object proximate to the mobile robot using the data captured by the one or more sensors, and identify information relating to one or more available stopping points. The system may identify a condition of the mobile robot that requires the mobile robot to stop and issue a command to the mobile robot to navigate to a particular one of the one or more available stopping points.

Abstract: The present disclosure relates to a heat sink pedestal including a composite material. The composite material may include at least one layer of a thermally conductive primary material and at least one layer of a thermally conductive secondary material. The composite material may include a conductivity ratio of lateral thermal conductivity (Kz) to planar thermal conductivity (Kx, Ky) of the composite material of at least 0. The heat sink pedestal may be conformable to a shape of a semiconductor chip.

Abstract: The present disclosure relates to a semiconductor package that may include a substrate, at least one die coupled to the substrate, and a stiffener coupled to the substrate, wherein the stiffener may include a stiffener frame, wherein the stiffener frame at least partially surrounds the at least one die. The stiffener may include at least one resilient member extending from the stiffener frame towards the at least one die, and the at least one resilient member may include a distal end that extends at a height above the substrate.

Abstract: The present invention provides a heat-driven adsorption vacuum dehumidification system including a vapor adsorption apparatus having a water permeable hydrophilic membrane separating the apparatus into at least a feed section and a low-pressure or vacuum section (evaporator), and providing a water vapor pressure difference to extract moisture from the air flowing through the apparatus into the evaporator, followed by adsorption in an adsorption chamber, and subsequently desorbed when acted as a desorption chamber to form water vapor which is condensed in a condenser. Adsorption and desorption chambers inter-change periodically to form a complete system cycle. Heating of chamber/compartment can be from waste heat or a renewable source in the absence of any electricity supplied externally. Related method for using a heat-driven adsorption vacuum dehumidification system to remove moisture from the air is also provided.

Abstract: A network verification system uses general-purpose programming language to create network verification tests. A test orchestrator builds a model of the network only using data from the network verification test. An optimization testing manager creates symbolic packets for verification tests using assertions based on a packet library embedded into the testing manager and the general-purpose programming language.

Abstract: A virtual network comprising virtual machines executing at a computing environment is implemented. A software defined networking (SDN) appliance is configured to provide a connection to computing resources via a virtual network of a virtual computing environment. The SDN appliance is configured to apply policies of the virtual computing environment to data traffic on the virtual network. The SDN appliance is operable to interact with multiple network devices that are configured to act as a hardware acceleration device for processing data traffic. Virtual addresses are assigned to the network devices. The SDN appliance executes a virtual switch configured to identify data traffic sent to or received from a host and act as a proxy for the network devices and respond on their behalf.

Abstract: The present invention relates to pharmaceutical compositions of ramelteon and methods of use thereof. More specifically, the present invention relates to pharmaceutical compositions of ramelteon for use in the treatment of insomnia and jet lag by transmucosal administration. The present invention achieved faster onset of pharmacological effects by delivery of low dosage of ramelteon via intranasal or sublingual routes, as compared to conventional oral tablet administration.

Abstract: Various methods and systems for implementing an autonomous configuration system for configuring a service infrastructure are provided. An autonomous configuration system implements a service infrastructure configuration manager to identify discovered configuration data. The discovered configuration data supports circumventing a routing protocol for service infrastructure communications via an edge infrastructure, such that, the service infrastructure is alternatively configured to access remote configuration data based on the discovered configuration data. The discovered configuration data is discovered based an autonomous discovery service (e.g., sniffing service or a casting service). An initial configuration state is configured in the service infrastructure, based on the discovered configuration data. The service infrastructure can communicate with a service provider infrastructure associated with the service infrastructure to access the remote configuration data.

Abstract: Various methods and systems for implementing an autonomous configuration system for configuring a service infrastructure are provided. An autonomous configuration system implements a service infrastructure configuration manager to identify discovered configuration data. The discovered configuration data supports circumventing a routing protocol for service infrastructure communications via an edge infrastructure, such that, the service infrastructure is alternatively configured to access remote configuration data based on the discovered configuration data. The discovered configuration data is discovered based an autonomous discovery service (e.g., sniffing service or a casting service). An initial configuration state is configured in the service infrastructure, based on the discovered configuration data. The service infrastructure can communicate with a service provider infrastructure associated with the service infrastructure to access the remote configuration data.

Abstract: Various methods and systems for implementing an autonomous configuration system for configuring a service infrastructure are provided. An autonomous configuration system implements a service infrastructure configuration manager to identify discovered configuration data. The discovered configuration data supports circumventing a routing protocol for service infrastructure communications via an edge infrastructure, such that, the service infrastructure is alternatively configured to access remote configuration data based on the discovered configuration data. The discovered configuration data is discovered based an autonomous discovery service (e.g., sniffing service or a casting service). An initial configuration state is configured in the service infrastructure, based on the discovered configuration data. The service infrastructure can communicate with a service provider infrastructure associated with the service infrastructure to access the remote configuration data.

Abstract: Sprayable aqueous pharmaceutical compositions containing granisetron or a pharmaceutically salt thereof, and pharmaceutically acceptable inactive ingredients, including tonicity agents, preservatives, and water soluble polymers with bioadhesive properties and/or capable of changing the rheological behavior in relation to ions, pH and temperature. The compositions are intranasally administered to a subject in need thereof in the rapid management and or prevention of nausea and/or vomiting induced by cytotoxic chemotherapy, radiation, or surgery. The composition has the advantages of rapid absorption and onset of action, prolonged drug plasma concentration and pharmacological effects comparable to intravenous infusion, as well as reduced nasal stinging sensation.

Abstract: Various methods and systems for implementing an autonomous configuration system for configuring a service infrastructure are provided. An autonomous configuration system implements a service infrastructure configuration manager to identify discovered configuration data. The discovered configuration data supports circumventing a routing protocol for service infrastructure communications via an edge infrastructure, such that, the service infrastructure is alternatively configured to access remote configuration data based on the discovered configuration data. The discovered configuration data is discovered based an autonomous discovery service (e.g., sniffing service or a casting service). An initial configuration state is configured in the service infrastructure, based on the discovered configuration data. The service infrastructure can communicate with a service provider infrastructure associated with the service infrastructure to access the remote configuration data.

Abstract: A circuit for common electrode voltage generation includes: a VCOM driver configured to output alternating voltage levels at an output thereof, the output being connected to a display panel; a switching circuit with a plurality of inputs and an output, being configured to select one of voltage levels at the inputs at a time and thereby to output alternating voltages levels at the output of the switching circuit; and a stabilizing capacitor with one end connected to the output of the VCOM driver, and the other end connected to the output of the switching circuit.