Patents by Inventor Kyeong Hoi Cha

Kyeong Hoi Cha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation process useful in synthesis of atorvastatin
    Patent number: 8124790
    Abstract: The present invention relates to a preparation process useful in synthesis of atorvastatin, more particularly a process for preparing atorvastatin is effective in treating hyperlipemia, comprising protecting the dihydroxy group at C3 and C5 positions of the starting material cis-t-butyl-6-substituted-3,5-dihydroxy-hexanoate with trialkyl orthoformate, reducing the terminal nitro or cyano group to amine group, performing JV-alkylation by sequentially reacting with ethyl 4-fluorobenzene-2-haloacetate and isobutyryl chloride, cyclizing with JV,3-diphenylpropynamide, and performing deprotection and hydrolysis.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: February 28, 2012
    Assignee: Medichem Korea Co., Ltd.
    Inventors: Dong-Ock Cho, Younja Kwon, Kyeong-Hoi Cha, Yeongsook Kim, Hyun-Seop Tae
  • Camptothecin compounds and a method of preparation thereof
    Patent number: 6265413
    Abstract: Camptothecin derivatives and pharmaceutically acceptable salts thereof, its manufacturing method and an antineoplastic agent containing it. The camptothecin derivatives are modified in B-ring and E-ring and show improved water solubility and enhanced antineoplastic effect.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: July 24, 2001
    Assignee: Chong Kun Dang Corp.
    Inventors: Sang Sup Jew, Hee Soon Lee, Joon Kyum Kim, Kwang Dae Ok, Kyeong Hoi Cha, Myoung Goo Kim, Kwang Kyun Lee, Jong Min Kim, Hee Jin Kim, Jeong Mi Hah
  • Intermediates for the synthesis of camptothecin derivatives
    Patent number: 6177568
    Abstract: Intermediates for the synthesis of camptothecin of the formula II wherein: R1 is —(CH2)2NR1R2, where R1 is an amino protecting group and R2 is C2-C5 alkyl, hydroxyethyl or acetoxyethyl group, and of the formula III wherein: n is 1 or 2; R3 is hydrogen or —OR4, where R4 is hydrogen, —COR5, —CONHR6 or CH2OR7, where R5 is methyl or —CH2OCH3, R6 is isopropyl, phenyl or —CH2CH2Cl, and R7 is methyl, ethyl or —CH2CH2OCH3; with the proviso that when n is 2, R3 is not hydrogen.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: January 23, 2001
    Assignee: Chong Kun Dang Corp.
    Inventors: Sang Sup Jew, Hee Soon Lee, Joon Kyum Kim, Kwang Dae Ok, Kyeong Hoi Cha, Myoung Goo Kim, Kwang Kyun Lee, Jong Min Kim, Hee Jin Kim, Jeong Mi Hah