Patents by Inventor Kyeong Man Hong

Kyeong Man Hong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients
    Patent number: 10085950
    Abstract: The present invention relates to a pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients. Specifically, the combinative treatment with gossypol and phenformin was verified to have a significantly higher anticancer activity than a single treatment with gossypol and phenformin alone. Therefore, the pharmaceutical composition of the present invention containing gossypol and phenformin having a synergetic anticancer activity can be favorably used for cancer treatment.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: October 2, 2018
    Assignee: National Cancer Center
    Inventors: Soo Youl Kim, Jong Heon Kim, Young Ki Bae, Ho Lee, Hyon Chol Jang, Yong-Doo Choi, Kyeong Man Hong, Dong Wan Hong
  • PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT CONTAINING GOSSYPOL AND PHENFORMIN AS ACTIVE INGREDIENTS
    Publication number: 20170071877
    Abstract: The present invention relates to a pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients. Specifically, the combinative treatment with gossypol and phenformin was verified to have a significantly higher anticancer activity than a single treatment with gossypol and phenformin alone. Therefore, the pharmaceutical composition of the present invention containing gossypol and phenformin having a synergetic anticancer activity can be favorably used for cancer treatment.
    Type: Application
    Filed: February 26, 2015
    Publication date: March 16, 2017
    Inventors: Soo Youl KIM, Jong Heon KIM, Young Ki BAE, Ho LEE, Hyon Chol JANG, Yong-Doo CHOI, Kyeong Man HONG, Dong Wan HONG
  • Method for measuring chromosome, gene or specific nucleotide sequence copy numbers using SNP array
    Patent number: 9012370
    Abstract: The present invention relates to a method for measuring the copy number of a chromosome, gene or specific nucleotide sequence, comprising the steps of: (a) mixing a homozygous DNA with a test sample DNA; (b) analyzing the DNA mixture by means of SNP array; and (c) determining the copy number of a chromosome, gene, or specific nucleotide sequence by measuring the difference in signal output from the homozygous DNA and the test sample DNA.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: April 21, 2015
    Assignee: National Cancer Center
    Inventor: Kyeong Man Hong
  • Composition for cancer prognosis prediction comprising anti-TMAP/CKAP2 antibodies
    Patent number: 8980570
    Abstract: The present invention relates to an antibody which specifically binds to TMAP (tumor associated microtubule associated protein)/CKAP2 (cytoskeleton associated protein 2) or a fragment thereof, and a method for identifying the presence or absence of mitosis and a method for diagnosing cancer prognosis using the same. More specifically, the present invention relates to a composition for diagnosing cancer prognosis comprising an anti-TMAP/CKAP2 antibody or an antigen-binding site thereof, a method for detecting TMAP/CKAP2 using the composition, an anti-TMAP/CKAP2 antibody for diagnosing cancer prognosis, a method for providing information for diagnosing cancer prognosis using the composition, a method for screening a cancer therapeutic agent comprising the step of determining changes in the level of TMAP/CKAP2 antigen-antibody reaction by the treatment of a candidate substance, and a composition for determining cell-division cycles using the composition.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: March 17, 2015
    Assignees: National Cancer Center, Research and Business Foundation Sungyunkwan University
    Inventors: Kyeong Man Hong, Chang Dae Bae, Joo Bae Park, Chang Ho Shin, Yong Book Choi
  • Composition for Cancer Prognosis Prediction Comprising Anti-TMAP/CKAP2 Antibodies
    Publication number: 20130045486
    Abstract: The present invention relates to an antibody which specifically binds to TMAP (tumor associated microtubule associated protein)/CKAP2 (cytoskeleton associated protein 2) or a fragment thereof, and a method for identifying the presence or absence of mitosis and a method for diagnosing cancer prognosis using the same. More specifically, the present invention relates to a composition for diagnosing cancer prognosis comprising an anti-TMAP/CKAP2 antibody or an antigen-binding site thereof, a method for detecting TMAP/CKAP2 using the composition, an anti-TMAP/CKAP2 antibody for diagnosing cancer prognosis, a method for providing information for diagnosing cancer prognosis using the composition, a method for screening a cancer therapeutic agent comprising the step of determining changes in the level of TMAP/CKAP2 antigen-antibody reaction by the treatment of a candidate substance, and a composition for determining cell-division cycles using the composition.
    Type: Application
    Filed: February 1, 2011
    Publication date: February 21, 2013
    Applicants: Research Business Foundation Sungkyunkwan University, NATIONAL CANCER CENTER
    Inventors: Kyeong Man Hong, Joo Bae Park, Chang Ho Shin, Yong Book Choi
  • DIAGNOSTIC COMPOSITION FOR AUTOIMMUNE DISEASES COMPRISING AGENT MEASURING CD3Z GENE METHYLATION LEVEL AND A METHOD FOR DIAGNOSING AUTOIMMUNE DISEASES USING THE SAME
    Publication number: 20120178633
    Abstract: The present invention relates to a diagnostic composition for autoimmune diseases, comprising agent measuring a methylation level of CD3Z gene, a diagnostic method and a kit using the same. More particularly, the present invention relates to a composition for diagnosing autoimmune diseases according to the methylation level of CD3Z gene, or additionally ADA or VHL gene, and a method for diagnosing autoimmune diseases by measuring the methylation level. The methylation of any one or more of the ADA, VHL, and CD3Z genes of the present invention is specific to autoimmune diseases, and thus the composition comprising an agent measuring a methylation level of the present invention can be used for the diagnosis of autoimmune diseases.
    Type: Application
    Filed: December 29, 2011
    Publication date: July 12, 2012
    Applicants: SNU R&DB FOUNDATION, NATIONAL CANCER CENTER
    Inventors: Kyeong Man HONG, Yeong Wook SONG
  • METHOD FOR MEASURING CHROMOSOME, GENE OR SPECIFIC NUCLEOTIDE SEQUENCE COPY NUMBERS USING SNP ARRAY
    Publication number: 20110105352
    Abstract: The present invention relates to a method for measuring the copy number of a chromosome, gene or specific nucleotide sequence, comprising the steps of: (a) mixing a homozygous DNA with a test sample DNA; (b) analyzing the DNA mixture by means of SNP array; and (c) determining the copy number of a chromosome, gene, or specific nucleotide sequence by measuring the difference in signal output from the homozygous DNA and the test sample DNA.
    Type: Application
    Filed: March 5, 2009
    Publication date: May 5, 2011
    Applicant: NATIONAL CANCER CENTER
    Inventor: Kyeong Man Hong