Patents by Inventor Kyle A. Ryan

Kyle A. Ryan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10703746
    Abstract: Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: July 7, 2020
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Matthew Brian Boxer, Jason Matthew Rohde, Rajan Pragani, Li Liu, Mindy Irene Emily Davis, Kyle Ryan Brimacombe, Min Shen, Anton Simeonov, Surendra Karavadhi, Daniel Jason Urban, Ajit Jadhav, Xiaodong Wang, Andrew Louis McIver
  • Patent number: 10619890
    Abstract: A thermal receiver, such as a solar flux thermal receiver, is disclosed comprising a modular arrangement of arrayed microchannels or micropins to heat a working fluid by heat transfer. Disclosed solar receivers provide a much higher solar flux and consequently a significant reduction in thermal losses, size, and cost, relative to known receivers. Unit cell receivers can be numbered up and combined in parallel to form modules, and modules combined to form full scale receivers.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: April 14, 2020
    Assignees: Oregon State University, The Regents of the University of California
    Inventors: Monte Kevin Drost, Sourabh Apte, Thomas L'Estrange, Vinod Narayanan, Charles Rymal, Eric Truong, Erfan Rasouli, Kyle Ryan Zada, Brian M. Fronk
  • Publication number: 20200002285
    Abstract: Provided is a compound of formula (I) in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 2, 2020
    Inventors: David J. Maloney, Alex Gregory Waterson, Ganesh Rai Bantukallu, Kyle Ryan Brimacombe, Plamen Christov, Chi V. Dang, Victor Darley-Usmar, Xin Hu, Ajit Jadhav, Somnath Jana, Kwangho Kim, Jennifer L. Kouznetsova, William J. Moore, Bryan T. Mott, Leonard M. Neckers, Anton Simeonov, Gary Allen Sulikowski, Daniel Jason Urban, Shyh Ming Yang
  • Patent number: 10513279
    Abstract: The invention provides an alarm comprising: (i) a plurality of trackside sensors with known locations each sensor to measure at least one characteristic of each railcar wheelset as it passes that sensor's location; (ii) an information store to receive, store and later provide the railcar wheelset characteristics measured by the track-side sensors; (iii) a preset or predetermined trigger pattern of wheelset characteristics associated with wheelset failure or some other railcar condition requiring alarm or notification action; and (iv) a comparator to compare historical measured characteristics about a particular wheelset from the information store to the trigger pattern. The alarm is triggered responsive to a comparator indication of a suitable match between chronologically contiguous historical measured characteristics about a particular wheelset in the information store with the trigger pattern.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: December 24, 2019
    Assignee: CANADIAN PACIFIC RAILWAY COMPANY
    Inventor: Kyle Ryan Mulligan
  • Publication number: 20190276448
    Abstract: The disclosure provides a compound of the formula (II) and pharmaceutically acceptable salts thereof. The variables, e.g. n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful for treating cancer and fibrosis. The compounds may be particularly useful for treating forms of cancer in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred. The disclosure also provides pharmaceutical compositions containing a compound of this formula and method for treating patients having cancer, fibrosis, or other conditions in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred.
    Type: Application
    Filed: June 29, 2017
    Publication date: September 12, 2019
    Inventors: David J. MALONEY, Alex Gregory WATERSON, Ganesha Rai BANTUKALLU, Kyle Ryan BRIMACOMBE, Plamen CHRISTOV, Chi V. DANG, Victor M. DARLEY-USMAR, Matthew HALL, Xin HU, Ajit JADHAV, Somnath JANA, Kwangho KIM, William J. MOORE, Bryan T. MOTT, Leonard M. NECKERS, Anton SIMEONOV, Gary Allen SULIKOWSKI, Daniel Jason URBAN, Shyh Ming YANG
  • Publication number: 20190241551
    Abstract: A compound of Formula II or a pharmaceutically acceptable salt thereof, wherein CyN is a cyclic amine group bound via a nitrogen atom; X is C or N; R1 and R2 are each independently a halogen, CN, CF3, CHF2, CH2F, a C1-C10alkyl group, a C1-C10alkoxy group, a di(C1-C5alkyl)amino; m and n are each independently 1, 2, or 3, and represents either a single bond or a double bond, wherein the racemic mixture of 3-(4-(4-chlorophenyl)thiazol-2-yl)-1-(2-ethyl-5-methoxyphenyl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one atropisomers is excluded.
    Type: Application
    Filed: June 21, 2017
    Publication date: August 8, 2019
    Inventors: Matthew Brian BOXER, Xiaodong WANG, Kyle Ryan BRIMACOMBE, Mindy Irene Emily DAVIS, Yuhong FANG, Matthew HALL, Ajit JADHAV, Surendra KARAVADHI, Li LIU, Natalia MARTINEZ, Andrew Louis MCIVER, Rajan PRAGANI, Jason Matthew ROHDE, Anton SIMEONOV, Wei ZHAO, Min SHEN
  • Patent number: 10351532
    Abstract: Provided is a compound of formula (I), in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: July 16, 2019
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, VANDERBILT UNIVERSITY, THE UAB RESEARCH FOUNDATION, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David J. Maloney, Alex Gregory Waterson, Ganesh Rai Bantukallu, Kyle Ryan Brimacombe, Plamen Christov, Chi V. Dang, Victor Darley-Usmar, Xin Hu, Ajit Jadhav, Somnath Jana, Kwangho Kim, Jennifer L. Kouznetsova, William J. Moore, Bryan T. Mott, Leonard M. Neckers, Anton Simeonov, Gary Allen Sulikowski, Daniel Jason Urban, Shyh Ming Yang
  • Publication number: 20190071434
    Abstract: Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.
    Type: Application
    Filed: December 22, 2015
    Publication date: March 7, 2019
    Inventors: Matthew Brian Boxer, Jason Matthew Rohde, Rajan Pragani, LI Liu, Mindy Irene Emily Davis, Kyle Ryan Brimacombe, Min Shen, Anton Simeonov, Surendra Karavadhi, Daniel Jason Urban, Ajit Jadhav, Xiaodong Wang, Andrew Louis McIver
  • Publication number: 20180273066
    Abstract: The invention provides an alarm comprising: (i) a plurality of trackside sensors with known locations each sensor to measure at least one characteristic of each railcar wheelset as it passes that sensor's location; (ii) an information store to receive, store and later provide the railcar wheelset characteristics measured by the track-side sensors; (iii) a preset or predetermined trigger pattern of wheelset characteristics associated with wheelset failure or some other railcar condition requiring alarm or notification action; and (iv) a comparator to compare historical measured characteristics about a particular wheelset from the information store to the trigger pattern. The alarm is triggered responsive to a comparator indication of a suitable match between chronologically contiguous historical measured characteristics about a particular wheelset in the information store with the trigger pattern.
    Type: Application
    Filed: August 30, 2017
    Publication date: September 27, 2018
    Inventor: KYLE RYAN MULLIGAN
  • Publication number: 20180273488
    Abstract: Provided is a compound of formula (I) [Formula (I) should be inserted here], in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.
    Type: Application
    Filed: December 29, 2015
    Publication date: September 27, 2018
    Inventors: David J. Maloney, Alex Gregory Waterson, Ganesh Rai Bantukallu, Kyle Ryan Brimacombe, Plamen Christov, Chi V. Dang, Victor Darley-Usmar, Xin Hu, Ajit Jadhav, Somnath Jana, Kwangho Kim, Jennifer L. Kouznetsova, William J. Moore, Bryan T. Mott, Leonard M. Neckers, Anton Simeonov, Gary Allen Sulikowski, Daniel Jason Urban, Shyh Ming Yang
  • Patent number: 9939112
    Abstract: Apparatus for use with fluid-processing plant configured to generate and store pressurized fluid. Fluid-processing plant is spaced apart from body of water. Apparatus includes variable-buoyancy assembly positioned in body of water in such way that buoyancy force urges variable-buoyancy assembly to move toward surface of body of water. Apparatus also includes non-collapsible fluid-line assembly positionally anchored, at least in part, underground in such way that non-collapsible fluid-line assembly extends, at least in part, into body of water. Non-collapsible fluid-line assembly fluidly connects fluid-processing plant and variable-buoyancy assembly together in such way that non-collapsible fluid-line assembly conveys pressurized fluid between fluid-processing plant and variable-buoyancy assembly.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: April 10, 2018
    Assignee: Hydrostar Inc.
    Inventors: Cameron Lewis, Curtis VanWalleghem, Kyle Ryan
  • Publication number: 20180010824
    Abstract: A thermal receiver, such as a solar flux thermal receiver, is disclosed comprising a modular arrangement of arrayed microchannels or micropins to heat a working fluid by heat transfer. Disclosed solar receivers provide a much higher solar flux and consequently a significant reduction in thermal losses, size, and cost, relative to known receivers. Unit cell receivers can be numbered up and combined in parallel to form modules, and modules combined to form full scale receivers.
    Type: Application
    Filed: July 5, 2017
    Publication date: January 11, 2018
    Applicants: Oregon State University, Regents of the University of California
    Inventors: Monte Kevin Drost, Sourabh Apte, Thomas L'Estrange, Vinod Narayanan, Charles Rymal, Eric Truong, Erfan Rasouli, Kyle Ryan Zada, Brian M. Fronk
  • Patent number: 9784413
    Abstract: Method is for operating fluid-processing plant configured to generate and store pressurized fluid, and spaced apart from body of water.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: October 10, 2017
    Assignee: Hydrostor Inc.
    Inventors: Cameron Lewis, Curtis VanWalleghem, Kyle Ryan
  • Publication number: 20160123515
    Abstract: Apparatus for use with fluid-processing plant configured to generate and store pressurized fluid. Fluid-processing plant is spaced apart from body of water. Apparatus includes variable-buoyancy assembly positioned in body of water in such way that buoyancy force urges variable-buoyancy assembly to move toward surface of body of water. Apparatus also includes non-collapsible fluid-line assembly positionally anchored, at least in part, underground in such way that non-collapsible fluid-line assembly extends, at least in part, into body of water. Non-collapsible fluid-line assembly fluidly connects fluid-processing plant and variable-buoyancy assembly together in such way that non-collapsible fluid-line assembly conveys pressurized fluid between fluid-processing plant and variable-buoyancy assembly.
    Type: Application
    Filed: October 29, 2014
    Publication date: May 5, 2016
    Inventors: Cameron Lewis, Curtis VanWalleghem, Kyle Ryan
  • Publication number: 20160123499
    Abstract: Method is for operating fluid-processing plant configured to generate and store pressurized fluid, and spaced apart from body of water.
    Type: Application
    Filed: October 29, 2014
    Publication date: May 5, 2016
    Inventors: Cameron Lewis, Curtis VanWalleghem, Kyle Ryan
  • Publication number: 20150133593
    Abstract: Nanomaterial-enhanced elastomers, methods for making them, and articles made with them.
    Type: Application
    Filed: December 7, 2012
    Publication date: May 14, 2015
    Inventors: Kyle Ryan kissell, Clayton Charles Galloway
  • Publication number: 20150093523
    Abstract: Coatings and heatable coatings containing electrically conductive nanomaterial; methods for making such a coating; items with such a coating; and methods for applying such a coating. In one aspect, such a coating is a deicing coating. This abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure and is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims, 37 C.F.R. 1.72(b).
    Type: Application
    Filed: September 30, 2013
    Publication date: April 2, 2015
    Inventors: Kyle Ryan Kissell, James BruceSinclair Sifton, William Doyle Stringfellow, John Bready Stuart
  • Patent number: 8986942
    Abstract: Compositions and methods related to carbon nanotubes are provided. More particularly, imaging agents comprising carbon nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon nanotube loaded with contrast agent; introducing the imaging agent into a cell; and imaging the cell to detect the presence of the imaging agent.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: March 24, 2015
    Assignee: William Marsh Rice University
    Inventors: Lon J. Wilson, Kyle Ryan Kissell, Keith Bennett Hartman
  • Publication number: 20150012815
    Abstract: A web application provides a custom selection for editing text on a gesture or touch screen. The application replaces native browser handles with selection handles to provide consistent user interface experience across platforms. The application also provides a scheme for semantic interpretation of browser gesture or touch events. The application standardizes browser events into a consistent stream of semantic events that are compatible with a plurality of devices and browsers. The application also provides a gesture or touch optimized user interface in the browser. The application determines gesture or touch input and optimizes the user interface according to the type of input.
    Type: Application
    Filed: September 24, 2014
    Publication date: January 8, 2015
    Inventors: Renu Devi, Barnabas Whitfield, Kyle Ryan, Trevor Harris, Mark Fields, Michael Herzfeld, Louisa Lee
  • Publication number: 20140354554
    Abstract: An improved dynamic user interface is provided. According to a type of input detected, an application UI may be optimized to the type of input. Optimization may include arrangement of functionality controls, as well as interaction models of UI elements to provide a better user experience depending on a type of input mechanism being used. If touch input is used, the functionality controls in a touch-optimized UI may be spaced farther apart, hit target areas may be larger, and behavior of the functionality controls may be optimized for touch input. If a user switches between touch and precision modes (e.g., the user uses a finger tap and a mouse), a precision UI may be presented, where functionality controls may be more compactly arranged and may utilize features specific to a mouse, pen/stylus, or other type of precision input device.
    Type: Application
    Filed: May 30, 2013
    Publication date: December 4, 2014
    Applicant: Microsoft Corporation
    Inventors: Renu Devi, Kyle Ryan