Abstract: Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.

Abstract: A thermal receiver, such as a solar flux thermal receiver, is disclosed comprising a modular arrangement of arrayed microchannels or micropins to heat a working fluid by heat transfer. Disclosed solar receivers provide a much higher solar flux and consequently a significant reduction in thermal losses, size, and cost, relative to known receivers. Unit cell receivers can be numbered up and combined in parallel to form modules, and modules combined to form full scale receivers.

Abstract: Provided is a compound of formula (I) in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

Abstract: The invention provides an alarm comprising: (i) a plurality of trackside sensors with known locations each sensor to measure at least one characteristic of each railcar wheelset as it passes that sensor's location; (ii) an information store to receive, store and later provide the railcar wheelset characteristics measured by the track-side sensors; (iii) a preset or predetermined trigger pattern of wheelset characteristics associated with wheelset failure or some other railcar condition requiring alarm or notification action; and (iv) a comparator to compare historical measured characteristics about a particular wheelset from the information store to the trigger pattern. The alarm is triggered responsive to a comparator indication of a suitable match between chronologically contiguous historical measured characteristics about a particular wheelset in the information store with the trigger pattern.

Abstract: The disclosure provides a compound of the formula (II) and pharmaceutically acceptable salts thereof. The variables, e.g. n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful for treating cancer and fibrosis. The compounds may be particularly useful for treating forms of cancer in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred. The disclosure also provides pharmaceutical compositions containing a compound of this formula and method for treating patients having cancer, fibrosis, or other conditions in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred.

Abstract: A compound of Formula II or a pharmaceutically acceptable salt thereof, wherein CyN is a cyclic amine group bound via a nitrogen atom; X is C or N; R1 and R2 are each independently a halogen, CN, CF3, CHF2, CH2F, a C1-C10alkyl group, a C1-C10alkoxy group, a di(C1-C5alkyl)amino; m and n are each independently 1, 2, or 3, and represents either a single bond or a double bond, wherein the racemic mixture of 3-(4-(4-chlorophenyl)thiazol-2-yl)-1-(2-ethyl-5-methoxyphenyl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one atropisomers is excluded.

Abstract: Provided is a compound of formula (I), in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

Abstract: Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.

Abstract: The invention provides an alarm comprising: (i) a plurality of trackside sensors with known locations each sensor to measure at least one characteristic of each railcar wheelset as it passes that sensor's location; (ii) an information store to receive, store and later provide the railcar wheelset characteristics measured by the track-side sensors; (iii) a preset or predetermined trigger pattern of wheelset characteristics associated with wheelset failure or some other railcar condition requiring alarm or notification action; and (iv) a comparator to compare historical measured characteristics about a particular wheelset from the information store to the trigger pattern. The alarm is triggered responsive to a comparator indication of a suitable match between chronologically contiguous historical measured characteristics about a particular wheelset in the information store with the trigger pattern.

Abstract: Provided is a compound of formula (I) [Formula (I) should be inserted here], in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

Abstract: Apparatus for use with fluid-processing plant configured to generate and store pressurized fluid. Fluid-processing plant is spaced apart from body of water. Apparatus includes variable-buoyancy assembly positioned in body of water in such way that buoyancy force urges variable-buoyancy assembly to move toward surface of body of water. Apparatus also includes non-collapsible fluid-line assembly positionally anchored, at least in part, underground in such way that non-collapsible fluid-line assembly extends, at least in part, into body of water. Non-collapsible fluid-line assembly fluidly connects fluid-processing plant and variable-buoyancy assembly together in such way that non-collapsible fluid-line assembly conveys pressurized fluid between fluid-processing plant and variable-buoyancy assembly.

Abstract: A thermal receiver, such as a solar flux thermal receiver, is disclosed comprising a modular arrangement of arrayed microchannels or micropins to heat a working fluid by heat transfer. Disclosed solar receivers provide a much higher solar flux and consequently a significant reduction in thermal losses, size, and cost, relative to known receivers. Unit cell receivers can be numbered up and combined in parallel to form modules, and modules combined to form full scale receivers.

Abstract: Method is for operating fluid-processing plant configured to generate and store pressurized fluid, and spaced apart from body of water.

Abstract: Apparatus for use with fluid-processing plant configured to generate and store pressurized fluid. Fluid-processing plant is spaced apart from body of water. Apparatus includes variable-buoyancy assembly positioned in body of water in such way that buoyancy force urges variable-buoyancy assembly to move toward surface of body of water. Apparatus also includes non-collapsible fluid-line assembly positionally anchored, at least in part, underground in such way that non-collapsible fluid-line assembly extends, at least in part, into body of water. Non-collapsible fluid-line assembly fluidly connects fluid-processing plant and variable-buoyancy assembly together in such way that non-collapsible fluid-line assembly conveys pressurized fluid between fluid-processing plant and variable-buoyancy assembly.

Abstract: Method is for operating fluid-processing plant configured to generate and store pressurized fluid, and spaced apart from body of water.

Abstract: Nanomaterial-enhanced elastomers, methods for making them, and articles made with them.

Abstract: Coatings and heatable coatings containing electrically conductive nanomaterial; methods for making such a coating; items with such a coating; and methods for applying such a coating. In one aspect, such a coating is a deicing coating. This abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure and is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims, 37 C.F.R. 1.72(b).

Abstract: Compositions and methods related to carbon nanotubes are provided. More particularly, imaging agents comprising carbon nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon nanotube loaded with contrast agent; introducing the imaging agent into a cell; and imaging the cell to detect the presence of the imaging agent.

Abstract: A web application provides a custom selection for editing text on a gesture or touch screen. The application replaces native browser handles with selection handles to provide consistent user interface experience across platforms. The application also provides a scheme for semantic interpretation of browser gesture or touch events. The application standardizes browser events into a consistent stream of semantic events that are compatible with a plurality of devices and browsers. The application also provides a gesture or touch optimized user interface in the browser. The application determines gesture or touch input and optimizes the user interface according to the type of input.

Abstract: An improved dynamic user interface is provided. According to a type of input detected, an application UI may be optimized to the type of input. Optimization may include arrangement of functionality controls, as well as interaction models of UI elements to provide a better user experience depending on a type of input mechanism being used. If touch input is used, the functionality controls in a touch-optimized UI may be spaced farther apart, hit target areas may be larger, and behavior of the functionality controls may be optimized for touch input. If a user switches between touch and precision modes (e.g., the user uses a finger tap and a mouse), a precision UI may be presented, where functionality controls may be more compactly arranged and may utilize features specific to a mouse, pen/stylus, or other type of precision input device.