Patents by Inventor Kyle A. Totaro

Kyle A. Totaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein inhibitors with reduced immunogenicity and resistance to degradation, and methods for their preparation and use
    Patent number: 11834480
    Abstract: Methods are provided to identify therapeutically useful peptides and polypeptides that bind to HR1 and may be used to treat coronavirus infections. Polypeptides and pharmaceutical compositions useful for such purposes are described.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: December 5, 2023
    Assignee: Amide Technologies
    Inventors: Kyle Totaro, Travis Ness, Brady Summers, Bradley Pentelute
  • SYNTHESIS OF FMOC-PROTECTED MORPHOLINO MONOMERS AND OLIGOMERS
    Publication number: 20230097585
    Abstract: The present disclosure provides the synthesis of phosphorodiamidate morpholino oligomers (PMOs) in high purity, yield, and efficiency from Fmoc-protected morpholino monomers, e.g., Fmoc morpholino monomer G.
    Type: Application
    Filed: June 10, 2022
    Publication date: March 30, 2023
    Inventors: Kyle A. Totaro, Ziqing Qian
  • PROTEIN INHIBITORS WITH REDUCED IMMUNOGENICITY AND RESISTANCE TO DEGRADATION, AND METHODS FOR THEIR PREPARATION AND USE
    Publication number: 20220119464
    Abstract: Methods are provided to identify therapeutically useful peptides and polypeptides that bind to HR1 and may be used to treat coronavirus infections. Polypeptides and pharmaceutical compositions useful for such purposes are described.
    Type: Application
    Filed: August 2, 2021
    Publication date: April 21, 2022
    Applicant: Amide Technologies
    Inventors: Kyle TOTARO, Travis Ness, Brady Summers, Bradley Pentelute
  • PROCESSES FOR PREPARING PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS VIA FAST-FLOW SYNTHESIS
    Publication number: 20200362339
    Abstract: Provided herein are processes for preparing an oligomer (e.g., a morpholino oligomer). The synthetic processes described herein may be advantageous to scaling up oligomer synthesis while maintaining overall yield and purity of a synthesized oligomer.
    Type: Application
    Filed: September 25, 2018
    Publication date: November 19, 2020
    Inventors: Kyle A. Totaro, Mark D. Simon, Ming Zhou, Hong Zong, Gunnar J. Hanson, Bradley L. Pentelute
  • NOVEL SYRINGOLIN ANALOGUES AND METHODS OF MAKING AND USING SAME
    Publication number: 20200216401
    Abstract: The present invention provides, in certain aspects, novel syringolin analogues, In certain embodiments, the compounds of the invention are proteasome inhibitors, In other embodiments, the compounds treat or prevent a cancer such as, but not limited to, leukemia in a subject,
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Inventors: Jason K. SELLO, Kyle A. TOTARO
  • Syringolin analogues and methods of making and using same
    Patent number: 10597368
    Abstract: The present invention provides, in certain aspects, novel syringolin analogues, In certain embodiments, the compounds of the invention are proteasome inhibitors, In other embodiments, the compounds treat or prevent a cancer such as, but not limited to, leukemia in a subject.
    Type: Grant
    Filed: May 7, 2016
    Date of Patent: March 24, 2020
    Assignee: BROWN UNIVERSITY
    Inventors: Jason K. Sello, Kyle A. Totaro
  • Novel Syringolin Analogues and Methods of Making and Using Same
    Publication number: 20190010133
    Abstract: The present invention provides, in certain aspects, novel syringolin analogues, In certain embodiments, the compounds of the invention are proteasome inhibitors, In other embodiments, the compounds treat or prevent a cancer such as, but not limited to, leukemia in a subject.
    Type: Application
    Filed: May 7, 2016
    Publication date: January 10, 2019
    Inventors: Jason K. Sello, Kyle A. Totaro
  • Methods of chemoselective derivation of multiple classes of metabolites
    Patent number: 9057698
    Abstract: Chemoselective derivatization of biological amines, carboxylic acids, aldehydes or ketones are employed in methods to detect a plurality of components, or members of a component, such as metabolites, that vary in molecular structure. The methods of the invention can be employed in aqueous and nonaqueous conditions.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: June 16, 2015
    Assignee: Brown University
    Inventors: Jason K. Sello, Kyle A. Totaro, Babajide O. Okandeji
  • METHODS OF CHEMOSELECTIVE DERIVATION OF MULTIPLE CLASSES OF METABOLITES
    Publication number: 20130071940
    Abstract: Chemoselective derivatization of biological amines, carboxylic acids, aldehydes or ketones are employed in methods to detect a plurality of components, or members of a component, such as metabolites, that vary in molecular structure. The methods of the invention can be employed in aqueous and nonaqueous conditions.
    Type: Application
    Filed: August 15, 2012
    Publication date: March 21, 2013
    Applicant: Brown University
    Inventors: Jason K. Sello, Kyle A. Totaro, Babajide O. Okandeji