Abstract: Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.

Abstract: A compute server receives a request that triggers execution of a code piece out of multiple code pieces. A single process at the compute server executes the code piece, which is run in an isolated execution environment. Each other code piece runs in other isolated execution environments respectively and executed by the single process. The code piece, when executed, modifies a response to the request. The response is generated based at least in part on the executed code piece. The generated response is transmitted.

Abstract: A detector assembly for a duct of a heating ventilation and air conditioning system includes an outer housing having at least one through hole formed therein, an inner sampling support receivable within a hollow interior of the outer housing, and at least one detector mounted to the inner sampling support. The at least one detector is axially aligned with the at least one through hole when the inner sampling support is installed within the hollow interior of the outer housing. The at least one detector is operable to sample air within the duct to detect a hazardous condition.

Abstract: A detector assembly for a duct of a heating ventilation and air conditioning system includes an outer housing having at least one through hole formed therein, an inner sampling support receivable within a hollow interior of the outer housing, and at least one detector mounted to the inner sampling support. The at least one detector is axially aligned with the at least one through hole when the inner sampling support is installed within the hollow interior of the outer housing. The at least one detector is operable to sample air within the duct to detect a hazardous condition.

Abstract: An environmental control unit for use with a transport container is provided. The environmental control unit includes: a thermoelectric device; a fan to blow air across the thermoelectric device; a cooling passage configured to receive the air blown across the thermoelectric device and convey the air to a compartment of a transport container when the transport container is removably connected to the environmental control unit; a controller in electronic communication with the thermoelectric device and the fan; a battery configured to power the environmental control unit; and one or more piezoelectric devices configured to generate electrical power to charge the battery, wherein each of the one or more piezoelectric devices is electrically connected to the battery.

Abstract: A detector assembly for a duct of a heating ventilation and air conditioning system includes an outer housing having at least one through hole formed therein, an inner sampling support receivable within a hollow interior of the outer housing, and at least one detector mounted to the inner sampling support. The at least one detector is axially aligned with the at least one through hole when the inner sampling support is installed within the hollow interior of the outer housing. The at least one detector is operable to sample air within the duct to detect a hazardous condition.

Abstract: An environmental control unit for use with a transport container is provided. The environmental control unit comprises: a thermoelectric device; a fan to blow air across the thermoelectric device; a cooling module configured to receive the air blown across the thermoelectric device and convey the air to a compartment of a transport container when the transport container is removably connected to the environmental control unit; a controller in electronic communication with the thermoelectric device and the fan; and a communication module in electronic communication with the controller, wherein the communication module is configured to transmit parameters of the environmental control unit to a computing device through wireless communication.

Abstract: Structural devices for energy dissipation can be designed to provide asymmetrical responses to cyclic axial loading. The energy dissipation devices can be designed to provide a known or predictable response to tensile loading, along with a different known or predictable response to compressive loading. The devices may include a filament which bears a portion of both tensile and compressive loads and a bracing device which provides lateral support to the filament to prevent buckling. Interlocks or a similar restraining mechanism can be used to resist part of either a compressive or tensile load. These components can be configured in such a manner as to provide an asymmetric response.

Abstract: Structural devices for energy dissipation can be designed to provide asymmetrical responses to cyclic axial loading. The energy dissipation devices can be designed to provide a known or predictable response to tensile loading, along with a different known or predictable response to compressive loading. The devices may include a filament which bears a portion of both tensile and compressive loads and a bracing device which provides lateral support to the filament to prevent buckling. Interlocks or a similar restraining mechanism can be used to resist part of either a compressive or tensile load. These components can be configured in such a manner as to provide an asymmetric response.

Abstract: A method and system of selecting assets for display in an interactive media guidance application includes receiving a user input indicating interest in a media item; generating a list of media assets related to the media item, selecting, based on priority rules, a subset of the media assets to display in an interactive media guidance application, and displaying an identifier for each of the subset of media assets in the interactive media guidance application screen. The priority rules may assign a first priority to one type of media asset and a second priority to a second type of media asset, and may be based on: whether the media asset has been viewed, and a respective time associated with the media asset.

Abstract: A method and system of selecting assets for display in an interactive media guidance application includes receiving a user input indicating interest in a media item; generating a list of media assets related to the media item, selecting, based on priority rules, a subset of the media assets to display in an interactive media guidance application, and displaying an identifier for each of the subset of media assets in the interactive media guidance application screen. The priority rules may assign a first priority to one type of media asset and a second priority to a second type of media asset, and may be based on: whether the media asset has been viewed, and a respective time associated with the media asset.

Abstract: Systems and methods for providing more flexible multi-user media content access using index points is provided. A plurality of custom index points are maintained in a multi-user or multi-room media system. After receiving a request to view an asset, a listing of the index points associated with the requested asset is presented to the user. Each index point may be associated with a current viewing location within the asset. After receiving a selection of an index point, the asset is accessed at the viewing position referenced by the index point, and the index point is updated based on the user's progress through the asset. Users may assign custom names and descriptions to the index points and be presented with cached video around the index point in order to more easily identify the relevance of the index point.

Abstract: A method and system of selecting assets for display in an interactive media guidance application includes receiving a user input indicating interest in a media item; generating a list of media assets related to the media item, selecting, based on priority rules, a subset of the media assets to display in an interactive media guidance application, and displaying an identifier for each of the subset of media assets in the interactive media guidance application screen. The priority rules may assign a first priority to one type of media asset and a second priority to a second type of media asset, and may be based on: whether the media asset has been viewed, and a respective time associated with the media asset.

Abstract: Systems and methods for providing more flexible multi-user media content access using index points is provided. A plurality of custom index points are maintained in a multi-user or multi-room media system. After receiving a request to view an asset, a listing of the index points associated with the requested asset is presented to the user. Each index point may be associated with a current viewing location within the asset. After receiving a selection of an index point, the asset is accessed at the viewing position referenced by the index point, and the index point is updated based on the user's progress through the asset. Users may assign custom names and descriptions to the index points and be presented with cached video around the index point in order to more easily identify the relevance of the index point.

Abstract: A pet refuse collection device includes a container body having an interior formed by a base and a surrounding sidewall. A movable lid encloses the interior. A scoop member is secured to either the container body or the lid so that, when the lid is closed, the scoop member is enclosed in the interior of the container body. A handle may be provided on the container body. In one embodiment, the scoop member is formed as an extension of the container body, for example, as a tongue-like extension, and in another embodiment the scoop member is a spoon-like member having its handle secured to the lid. The lid may be pivotally attached to the container body and may be spring biased to an open position. A latch can be used to retain the lid in the closed position.