Patents by Inventor Kyle Armantrout
Kyle Armantrout has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11713489Abstract: Embodiments of present disclosure are directed to methods for amplifying nucleic acid, comprising two steps: a first step of preparing a reaction mixture comprising the target nucleic acid and a second step of processing the reaction mixture in a thermocycler. During a first phase of the processing step, the thermocycler may be configured to heat the reaction mixture to a first temperature and cool the reaction mixture to a second temperature repeatedly for a first plurality of cycles. During the first phase, fluorescence probes do not anneal to template strands and do not emit fluorescence signals. During a second phase of the processing step, the thermocycler may heat the reaction mixture to a third temperature and cool the reaction mixture to a fourth temperature repeatedly for a second plurality of cycles.Type: GrantFiled: October 26, 2020Date of Patent: August 1, 2023Assignee: Tetracore, Inc.Inventors: William M. Nelson, Kyle Armantrout, Tracy Calvin Fecteau
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Patent number: 11590433Abstract: A method and system for solid phase extraction of a compound of interest from a sample matrix using a syringe having a barrel and a plunger, a sorbent for use with the syringe, and a desalting purification column having an end configured to receive liquid from the syringe body.Type: GrantFiled: November 27, 2019Date of Patent: February 28, 2023Assignee: Tetracore, Inc.Inventors: William M. Nelson, Kyle Armantrout, David R. Almassian, Aymeric Randanne de Vazeille, Tracy Calvin Fecteau, Colin Kuserk
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Publication number: 20220372564Abstract: Systems and methods for detecting the presence of a target nucleic acid in a sample via a recombinase polymerase amplification (RPA) reaction followed by a FEN1 cleavage detection reaction are disclosed. One aspect of the present disclosure relates to systems involving a sample collection device for collecting a sample and performing an RPA reaction on the sample, followed by the detection of the amplified product via a two-step FEN1 cleavage detection reaction which generates a fluorescent signal indicative of the presence of amplified product.Type: ApplicationFiled: May 21, 2021Publication date: November 24, 2022Applicant: TETRACORE, INC.Inventors: Kyle GERBER, Lisa COCKRELL, William NELSON, Kyle ARMANTROUT
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Publication number: 20210363568Abstract: Embodiments of present disclosure are directed to methods for amplifying nucleic acid, comprising two steps: a first step of preparing a reaction mixture comprising the target nucleic acid and a second step of processing the reaction mixture in a thermocycler. During a first phase of the processing step, the thermocycler may be configured to heat the reaction mixture to a first temperature and cool the reaction mixture to a second temperature repeatedly for a first plurality of cycles. During the first phase, fluorescence probes do not anneal to template strands and do not emit fluorescence signals. During a second phase of the processing step, the thermocycler may heat the reaction mixture to a third temperature and cool the reaction mixture to a fourth temperature repeatedly for a second plurality of cycles.Type: ApplicationFiled: October 26, 2020Publication date: November 25, 2021Applicant: Tetracore, Inc.Inventors: William M. NELSON, Kyle ARMANTROUT, Tracy Calvin FECTEAU
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Publication number: 20200391214Abstract: A self-metering reaction device has a sample reservoir, configured to accept a varying amount of fluid; a metering reservoir, configured to be a subportion of the sample reservoir and to hold a reaction amount of the fluid; a reaction chamber fluidly connected to the metering reservoir; and a plunger comprising a tip configured to make a seal with the metering reservoir so that the reaction amount of the fluid is sealed within the metering reservoir when the plunger is in contact with the metering reservoir. The plunger can be configured to plunge the sealed reaction amount of the fluid from the metering reservoir into the reaction chamber.Type: ApplicationFiled: August 28, 2020Publication date: December 17, 2020Inventors: William M. Nelson, Aymeric Randanne de Vazeille, Kyle Armantrout
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Patent number: 10837065Abstract: Embodiments of present disclosure are directed to methods for amplifying nucleic acid, comprising two steps: a first step of preparing a reaction mixture comprising the target nucleic acid and a second step of processing the reaction mixture in a thermocycler. During a first phase of the processing step, the thermocycler may be configured to heat the reaction mixture to a first temperature and cool the reaction mixture to a second temperature repeatedly for a first plurality of cycles. During the first phase, fluorescence probes do not anneal to template strands and do not emit fluorescence signals. During a second phase of the processing step, the thermocycler may heat the reaction mixture to a third temperature and cool the reaction mixture to a fourth temperature repeatedly for a second plurality of cycles.Type: GrantFiled: August 12, 2016Date of Patent: November 17, 2020Assignee: TETRACORE, INC.Inventors: William M. Nelson, Kyle Armantrout, Tracy Calvin Fecteau
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Patent number: 10758908Abstract: A self-metering reaction device has a sample reservoir, configured to accept a varying amount of fluid; a metering reservoir, configured to be a subportion of the sample reservoir and to hold a reaction amount of the fluid; a reaction chamber fluidly connected to the metering reservoir; and a plunger comprising a tip configured to make a seal with the metering reservoir so that the reaction amount of the fluid is sealed within the metering reservoir when the plunger is in contact with the metering reservoir. The plunger can be configured to plunge the sealed reaction amount of the fluid from the metering reservoir into the reaction chamber.Type: GrantFiled: September 2, 2016Date of Patent: September 1, 2020Assignee: Tetracore, Inc.Inventors: William M. Nelson, Aymeric Randanne de Vazeille, Kyle Armantrout
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Publication number: 20200094165Abstract: A method and system for solid phase extraction of a compound of interest from a sample matrix using a syringe having a barrel and a plunger, a sorbent for use with the syringe, and a desalting purification column having an end configured to receive liquid from the syringe body.Type: ApplicationFiled: November 27, 2019Publication date: March 26, 2020Inventors: William M. Nelson, Kyle Armantrout, David R. Almassian, Aymeric Randanne de Vazeille, Tracy Calvin Fecteau, Colin Kuserk
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Patent number: 10525375Abstract: A method and system for solid phase extraction of a compound of interest from a sample matrix using a syringe having a barrel and a plunger, a sorbent for use with the syringe, and a desalting purification column having an end configured to receive liquid from the syringe body.Type: GrantFiled: August 12, 2016Date of Patent: January 7, 2020Assignee: Tetracore, Inc.Inventors: William M. Nelson, Kyle Armantrout, David R. Almassian, Aymeric Randanne de Vazeille, Tracy Calvin Fecteau, Colin Kuserk
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Publication number: 20170065980Abstract: A self-metering reaction device has a sample reservoir, configured to accept a varying amount of fluid; a metering reservoir, configured to be a subportion of the sample reservoir and to hold a reaction amount of the fluid; a reaction chamber fluidly connected to the metering reservoir; and a plunger comprising a tip configured to make a seal with the metering reservoir so that the reaction amount of the fluid is sealed within the metering reservoir when the plunger is in contact with the metering reservoir. The plunger can be configured to plunge the sealed reaction amount of the fluid from the metering reservoir into the reaction chamber.Type: ApplicationFiled: September 2, 2016Publication date: March 9, 2017Inventors: William M. Nelson, Aymeric Randanne de Vazeille, Kyle Armantrout
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Publication number: 20170044518Abstract: A method and system for solid phase extraction of a compound of interest from a sample matrix using a syringe having a barrel and a plunger, a sorbent for use with the syringe, and a desalting purification column having an end configured to receive liquid from the syringe body.Type: ApplicationFiled: August 12, 2016Publication date: February 16, 2017Inventors: William M. Nelson, Kyle Armantrout, David R. Almassian, Aymeric Randanne de Vazeille, Tracy Calvin Fecteau, Colin Kuserk
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Publication number: 20170044585Abstract: Embodiments of present disclosure are directed to methods for amplifying nucleic acid, comprising two steps: a first step of preparing a reaction mixture comprising the target nucleic acid and a second step of processing the reaction mixture in a thermocycler. During a first phase of the processing step, the thermocycler may be configured to heat the reaction mixture to a first temperature and cool the reaction mixture to a second temperature repeatedly for a first plurality of cycles. During the first phase, fluorescence probes do not anneal to template strands and do not emit fluorescence signals. During a second phase of the processing step, the thermocycler may heat the reaction mixture to a third temperature and cool the reaction mixture to a fourth temperature repeatedly for a second plurality of cycles.Type: ApplicationFiled: August 12, 2016Publication date: February 16, 2017Inventors: William M. Nelson, Kyle Armantrout, Tracy Calvin Fecteau
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Publication number: 20070087345Abstract: The present invention relates to compositions, methods, and kits for quantifying variations in gene copy number, e.g., of individual genes or of chromosomes or portions of chromosomes in an homogeneous reaction, without the need for target amplification, fragment size resolution, or microscopy.Type: ApplicationFiled: July 9, 2004Publication date: April 19, 2007Applicant: THIRD WAVE TECHNOLOGIES, INC.Inventors: Marilyn Olson-Munoz, Michelle Curtis, Kyle Armantrout, Feng Cao, Bonnie Hurwitz, Daniel Machmeier, Sara Olson, Hon Ip, Robert Kwiatkowski Jr, LuAnne Chehak