Abstract: Embodiments include a method of diagnosing gastroparesis or suspected gastroparesis, the method comprising: obtaining data representing a time series of readings from gas sensing apparatus housed within a ingestible capsule device orally ingested by a subjected; processing the readings to detect one or more gastroparesis indicator spikes in the CO2 concentration with respect to time; based on the detected one or more gastroparesis indicator spikes in the CO2 concentration with respect to time, diagnosing gastroparesis or suspected gastroparesis.

Abstract: Embodiments include a method for detecting small intestinal bacterial overgrowth, SIBO, the method comprising: obtaining data representing a time series of readings from gas sensor hardware housed within an ingestible capsule device orally ingested by a subject, identifying the data corresponding to timing of passage through the small intestine, and determining whether or not the data indicates presence of SIBO.

Abstract: Embodiments include an ingestible capsule being configured, in response to identification of an excretion marker from on-board sensor hardware, to determine occurrence of an excretion event, and in response to determining occurrence of the excretion event to modify one or more settings of the wireless data transmitter to start, restart, increase transmission power of, or increase a rate of, wireless transmission of the data transmission payload away from the ingestible capsule by a wireless data transmitter.

Abstract: Embodiments include an ingestible capsule comprising a housing including a therapeutic payload carrying compartment; a power supply; a release mechanism; and a sensing mechanism, the sensing mechanism being sensitive to an environment external to the housing; the ingestible capsule being configured for passage through a GI tract of a subject mammal, during which passage: the sensing mechanism is configured to output a signal varying according to a GI tract environment, wherein the sensing mechanism comprises one or more sensors from among: a VOC gas sensor; a TCD gas sensor; a reflectometer formed by a transmission antenna of the ingestible capsule connected in series with a directional coupler configured to measure a reflected signal from the transmission antenna; and an accelerometer; the release mechanism is configured to cause a therapeutic payload to be released into the GI tract from the therapeutic payload carrying compartment at a release timing determined according to the output signal.

Abstract: A method of determining a location of an ingestible capsule within a gastrointestinal tract of a subject mammal, the method comprising providing the ingestible capsule to the subject mammal for ingestion, the ingestible capsule comprising a housing, a power source, a TCD gas sensor, and a VOC gas sensor; recording readings of the ingestible capsule as a function of time, the readings including TCD gas sensor readings and VOC gas sensor readings; processing the recorded readings, including: determining a timing of a gastric-duodenal transition, wherein determining the timing comprises detecting a gastric-duodenal transition indicator in recorded readings including the recorded TCD gas sensor readings; and determining a timing of a transition across an ileocecal junction by the ingestible capsule, wherein determining the timing comprises detecting an ileocecal junction indicator in recorded readings including the VOC gas sensor readings.

Abstract: A capsule adapted to be introduced into the digestive system and gastrointestinal (GI) tract of a mammal which consists of a capsule shaped container consisting of a wall material capable of being bio compatible with the digestive system and being adapted to protect the electronic and sensor devices contained in the capsule. The capsule contains gas composition sensors operable at several temperature points for a short duration, a temperature sensor, a micro controller, a power source and a wireless transmission device. The capsule wall incorporates gas permeable membranes adjacent said gas sensors. The microprocessor is programmed to receive data signals from the sensors and convert the signals into gas composition and concentration data and temperature data suitable for transmission to an external computing device.

Abstract: A conditioned air blower system for ventilating a trailer interior includes a centrifugal blower and a heat exchange unit. The centrifugal blower includes a blower housing, an inlet portion configured to direct air into the blower housing, and a discharge portion configured to direct air from the blower housing into the trailer interior. The heat exchange unit includes an air inlet portion, heat exchange elements, and a conditioned air exit portion coupled to the inlet portion of the centrifugal blower. The heat exchange unit conditions ambient air introduced at the air inlet portion from a first temperature to a second temperature by heat exchange relationship with the heat exchange elements. The conditioned air blower system may include a controller operatively associated with the centrifugal blower. The controller monitors a condition related to the centrifugal blower, and regulates the supply of temperature-conditioned air in response to the condition.

Abstract: A gas permeable, liquid impermeable membrane for use with gas sensors consists of a film forming polymer which incorporates nanoparticles selected to improve one or more of the following: permeability to gases, to selectively regulate permeability of selected gases through the membrane, to inhibit microbial growth on the membrane. A capsule shaped container consists of wall material biocompatible with a mammal GI tract and adapted to protect the electronic and sensor devices in the capsule, which contains gas composition sensors, pressure and temperature sensors, a microcontroller, a power source and a wireless transmission device. The microprocessor receives data signals from the sensors and converts the signals into gas composition and concentration data and temperature and pressure data for transmission to an external computing device.

Abstract: An air moving device includes an outer casing comprising an outer diameter, an inner portion defining a flow path, an inlet portion defining an inlet cross-sectional area, and an opposing outlet portion defining an outlet cross-sectional area. A motor assembly is disposed within the outer casing, and a hub and blade assembly is secured to a shaft on the motor assembly. The air moving device further includes a de-swirl vane package. The package includes a plurality of de-swirl vanes disposed in the flow path. The blades are characterized by one or more resonant frequencies, and a potential excitation source of the blade resonant frequencies is a flow path obstruction comprising a plurality of objects substantially equally spaced about the circumference of the flow path. The flow path obstruction is characterized by a periodic frequency. The periodic frequency differs from the blade resonant frequencies by a safety margin of at least 20%.

Abstract: Disclosed herein is a method for determining a type and corresponding concentration of at least one gas in a multi-gas mixture, the method including: exposing a gas sensitive element of a gas sensor to the multi-gas mixture; modulating a drive signal supplied to a temperature control element of the gas sensor to cause a temperature of the gas sensitive element to change from an initial temperature; recording a transient impedance response of the gas sensitive element while the temperature of the gas sensitive element changes to obtain a transient impedance response that is characteristic of the multi-gas mixture; using the transient impedance response to determine a type and corresponding concentration of at least one gas in the multi-gas sample from a database including calibration data corresponding to the at least one gas.

Abstract: A capsule adapted to be introduced into the digestive system and gastrointestinal (Gl) tract of a mammal which consists of a capsule shaped container consisting of a wall material capable of being bio compatible with the digestive system and being adapted to protect the electronic and sensor devices contained in the capsule. The capsule contains gas composition sensors operable at several temperature points for a short duration, a temperature sensor, a micro controller, a power source and a wireless transmission device. The capsule wall incorporates gas permeable membranes adjacent said gas sensors. The microprocessor is programmed to receive data signals from the sensors and convert the signals into gas composition and concentration data and temperature data suitable for transmission to an external computing device.

Abstract: An air moving device includes an outer casing comprising an outer diameter, an inner portion defining a flow path, an inlet portion defining an inlet cross-sectional area, and an opposing outlet portion defining an outlet cross-sectional area. A motor assembly is disposed within the outer casing, and a hub and blade assembly is secured to a shaft on the motor assembly. The air moving device further includes a de-swirl vane package. The package includes a plurality of de-swirl vanes disposed in the flow path. The blades are characterized by one or more resonant frequencies, and a potential excitation source of the blade resonant frequencies is a flow path obstruction comprising a plurality of objects substantially equally spaced about the circumference of the flow path. The flow path obstruction is characterized by a periodic frequency. The periodic frequency differs from the blade resonant frequencies by a safety margin of at least 20%.

Abstract: A conditioned air blower system for ventilating a trailer interior includes a centrifugal blower and a heat exchange unit. The centrifugal blower includes a blower housing, an inlet portion configured to direct air into the blower housing, and a discharge portion configured to direct air from the blower housing into the trailer interior. The heat exchange unit includes an air inlet portion, heat exchange elements, and a conditioned air exit portion coupled to the inlet portion of the centrifugal blower. The heat exchange unit conditions ambient air introduced at the air inlet portion from a first temperature to a second temperature by heat exchange relationship with the heat exchange elements. The conditioned air blower system may include a controller operatively associated with the centrifugal blower. The controller monitors a condition related to the centrifugal blower, and regulates the supply of temperature-conditioned air in response to the condition.

Abstract: A gas permeable, liquid impermeable membrane for use with gas sensors consists of a film forming polymer which incorporates nanoparticles selected to improve one or more of the following: permeability to gases, to selectively regulate permeability of selected gases through the membrane, to inhibit microbial growth on the membrane. A capsule shaped container consists of wall material biocompatible with a mammal GI tract and adapted to protect the electronic and sensor devices in the capsule, which contains gas composition sensors, pressure and temperature sensors, a microcontroller, a power source and a wireless transmission device. The microprocessor receives data signals from the sensors and converts the signals into gas composition and concentration data and temperature and pressure data for transmission to an external computing device.