Abstract: A method of processing objects with a programmable motion device is disclosed. The method includes receiving a plurality of received objects at an input area proximate the programmable motion device, selecting and grasping a first object of the plurality of received objects from the input area using the programmable motion device, moving the first object to a cache area using the programmable motion device, said cache area being proximate the programmable motion device, selecting and grasping a second object of the plurality of received objects, moving the second object to a first destination location using the programmable motion device, selecting and grasping the first object from the cache area using the programmable motion device, and moving the first object to the first destination location using the programmable motion device.

Abstract: Exosomes are a small type of extracellular vesicles containing nucleic acids, lipids, and proteins that are implicated in tumorigenesis, metastasis, and cardiac regeneration, and therefore serve as potentially useful biomarkers from fluids or as vehicles for drug delivery. Global bottom-up mass spectrometry-based proteomics has been previously used to profile exosome cargo for diagnostic purposes. However, the current protocols for MS analysis of extracellular vesicles and exosome proteomics are challenging due to labor-intensive sample preparation, including lengthy digestion times and removal of MS incompatible reagents, and the need for high sensitivity. To address these challenges, the present invention provides a novel, high-throughput strategy for extracellular vesicle analysis and exosome proteomics using a photo-cleavable, anionic surfactant, preferably 4-hexylphenylazosulfonate (Azo).

Abstract: A pressure safety device and tool for operating said device, a pressurized container system, process, and methods of use are presented. The present disclosure provides a pressure relief valve that doubles as a tool to remove a tri clamp nut. The present disclosure further includes and provides the state of the art with a keyed pressure relief system for a pressurized container. Said another way, the present disclosure provides for a pressurized container, relief system, and tool for operation and safety. The present disclosure provides a removable pressure relief tool and a unique and novel new tri clamp nut assembly, and new tri clamp nut. The disclosure decreases the risk of injury associated with the accidental removal of a tri clamp fitting from pressurized vessels. Furthermore, the present disclosure provides a unique system which renders the tool inaccessible unless removed from the vessel, which causes depressurization.

Abstract: Methods, computer program products, and systems are presented. The method computer program products, and systems can include, for instance: marking of a request to define a marked request that includes associated metadata, wherein the metadata specifies action for performing by a resource interface associated to a production environment resource of a production environment, wherein the resource interface is configured for emulating functionality of the production environment resource; and sending the marked request to the resource interface for performance of the action specified by the metadata.

Abstract: A system is disclosed for processing objects using a programmable motion device. The system includes an end-effector of the programmable motion device for grasping an object from an in-feed container, and a control system for determining a payload guard for the selected object. The payload guard includes pointcloud data regarding volumetric data that include a volume occupied by the selected object, and the payload guard is determined responsive to at least one characteristic of the selected object and is provided specific to the selected object.

Abstract: The present invention provides nonionic cleavable surfactants (NCS), specifically n-Decyl-disulfide-?-D-maltoside (DSSM), suitable for MS-based proteomics and analysis. These surfactants are designed to mimic the properties of a commonly used surfactant in structural biology, n-dodecyl-?-d-maltoside (DDM), but contain a disulfide bond that allows for facile cleavage and surfactant removal before analysis. DSSM and other NCS are compatible with native mass spectrometry, top-down and bottom-up proteomics, ESI-MS and other analytical techniques, and reduce signal suppression typically observed with other surfactants. DSSM and other NCS provide versatile surfactants that can facilitate protein sample preparation under non-denaturing conditions for a myriad of proteomic and structural biology applications and act as a general replacement for DDM.

Abstract: A lumber cutting and delivery system for use in assembling trusses on a truss table includes a saw for cutting a piece of material into pieces of a truss. A trunk conveyor system receives the pieces cut from the saw. The trunk conveyor system has a first conveying element to transport the pieces over a distance in a travel direction and an ejector for discharging the pieces from the first conveying element in a first discharge direction. A branch conveyor system is configured to receive the pieces discharged from the trunk conveyor system in the first discharge direction. The branch conveyor system has a main conveying element to transport the pieces.

Abstract: A system for enhanced conveying of flexible packages includes a packaging system, an inflation system, and a conveying system. The packaging system is configured to place an object in a flexible package. The inflation system is configured to insert a gas into the flexible package. The packaging system is further configured to seal an edge of the flexible package in an inflated state with the object and the inserted gas inside the flexible package. The conveying system is configured to convey the flexible package while the flexible package is substantially in the inflated state. The flexible package is configured to permit gas to escape the flexible package at a controlled flow rate such that the flexible package remains substantially in the inflated state while being conveyed by the conveying system and the flexible package transitions to being substantially in a deflated state after being conveyed by the conveying system.

Abstract: A lumber cutting and delivery system for use in assembling trusses on a truss table includes a saw configured to receive a piece of material therein. The saw is configured to cut the piece of material into one or more pieces and at different lengths and angles so that at least some of the one or more pieces are the components of at least one truss. A trunk conveyor system is positioned to receive the one or more pieces cut from the saw. The trunk conveyor system has a first conveying element to transport the one or more pieces over a distance in a travel direction and an ejector configured to discharge the one or more pieces from the first conveying element in a first discharge direction. A branch conveyor system is configured to receive the one or more pieces discharged from the trunk conveyor system in the first discharge direction. The branch conveyor system has a main conveying element to transport the one or more pieces.

Abstract: Apparatuses, systems, and methods for implanting an intraocular lens into an eye are described. For example, an intraocular lens injector may include a passage formed in a distal end portion of the intraocular lens injector. The passage may define an interior surface, and a ramp may be formed on the interior surface so as to cause a leading haptic of an intraocular lens (IOL) being advanced through the passage to lift above a surface of an optic of the IOL to ensure proper folding of the IOL.

Abstract: The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-translational modifications.

Abstract: Exosomes are a small type of extracellular vesicles containing nucleic acids, lipids, and proteins that are implicated in tumorigenesis, metastasis, and cardiac regeneration, and therefore serve as potentially useful biomarkers from fluids or as vehicles for drug delivery. Global bottom-up mass spectrometry-based proteomics has been previously used to profile exosome cargo for diagnostic purposes. However, the current protocols for MS analysis of extracellular vesicles and exosome proteomics are challenging due to labor-intensive sample preparation, including lengthy digestion times and removal of MS incompatible reagents, and the need for high sensitivity. To address these challenges, the present invention provides a novel, high-throughput strategy for extracellular vesicle analysis and exosome proteomics using a photo-cleavable, anionic surfactant, preferably 4-hexylphenylazosulfonate (Azo).

Abstract: The disclosure provides an automated container resizing apparatus and system, an automated method of resizing a container, and a cutting tool that can be used for the resizing. In one example, the system includes the cutting tool, a controller, a conveyor, and a moveable support that can be a robotic arm. The controller can operate the conveyor to position a container in a cutting zone. The dimensions of the box and product fill height within the container are obtained and translated by the controller into a programmed cutting pattern. The controller then operates the robotic arm to perform the programmed cutting pattern on the box with the cutting tool. The cutting tool can be mounted on the robotic arm that rotates about its axis to cut side walls of the container for resizing.

Abstract: Apparatuses, systems, and methods for implanting an intraocular lens into an eye are described. For example, an intraocular lens injector may include a passage formed in a distal end portion of the intraocular lens injector. The passage may define an interior surface, and a ramp may be formed on the interior surface so as to cause a leading haptic of an intraocular lens (IOL) being advanced through the passage to lift above a surface of an optic of the IOL to ensure proper folding of the IOL.

Abstract: The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-translational modifications.

Abstract: Systems and methods may be used to generate and use intent predictions to enhance user experience. The intent predictions may describe the data required to resolve a user request included in a user input (e.g., question, search query, and the like) submitted by a user. The intent predictions may be generated using a machine learning model that comprises a model framework for extracting features and classifying user inputs into intent classes based on the extracted features. The intent predictions may be integrated into an information service to improve business metrics including contact rate, transfer rate, helpful rate, and net total promoter score.

Abstract: Apparatuses, systems, and methods for implanting an intraocular lens into an eye are described. For example, an intraocular lens injector may include a plunger and an injector body that includes an insertion depth guard and a nozzle extending therefrom. The insertion depth guard is disposed at a distal end of the injector body to limit a distance that the nozzle penetrates the eye. The intraocular lens injector may also include a biasing element configured to generate a counterforce to distal movement of the plunger through the injector rod. An example intraocular lens injector may include a biasing element to produce a counterforce that opposes advancement of the plunger through the injector body. The counterforce provides for a more continuous advancement of the plunger while reducing or substantially eliminating abrupt changes in the rate at which the plunger is advanced through the injector body.

Abstract: A system for enhanced conveying of flexible packages includes a packaging system, an inflation system, and a conveying system. The packaging system is configured to place an object in a flexible package. The inflation system is configured to insert a gas into the flexible package. The packaging system is further configured to seal an edge of the flexible package in an inflated state with the object and the inserted gas inside the flexible package. The conveying system is configured to convey the flexible package while the flexible package is substantially in the inflated state. The flexible package is configured to permit gas to escape the flexible package at a controlled flow rate such that the flexible package remains substantially in the inflated state while being conveyed by the conveying system and the flexible package transitions to being substantially in a deflated state after being conveyed by the conveying system.

Abstract: Apparatuses, systems, and methods for implanting an intraocular lens into an eye are described. For example, an intraocular lens injector may include a plunger and an injector body that includes an insertion depth guard and a nozzle extending therefrom. The insertion depth guard is disposed at a distal end of the injector body to limit a distance that the nozzle penetrates the eye. The intraocular lens injector may also include a biasing element configured to generate a counterforce to distal movement of the plunger through the injector rod. An example intraocular lens injector may include a biasing element to produce a counterforce that opposes advancement of the plunger through the injector body. The counterforce provides for a more continuous advancement of the plunger while reducing or substantially eliminating abrupt changes in the rate at which the plunger is advanced through the injector body.

Abstract: A system for enhanced conveying of flexible packages includes a packaging system (12, 212), an inflation system (280), and a conveying system (250). The packaging system is configured to place an object in a flexible package. The inflation system is configured to insert a gas into the flexible package. The packaging system is further configured to seal an edge of the flexible package in an inflated state with the object and the inserted gas inside the flexible package. The conveying system is configured to convey the flexible package while the flexible package is substantially in the inflated state. The flexible package is configured to permit gas to escape the flexible package at a controlled flow rate such that the flexible package remains substantially in the inflated state while being conveyed by the conveying system and the flexible package transitions to being substantially in a deflated state after being conveyed by the conveying system.