Abstract: Systems and methods are provided for analyzing a test sample is provided. A system includes an outer container having first and second ends and a base affixed to the first end. The system includes a motorized mixer affixed to the base. The system includes an inner container having first and second ends. The inner container is sized to be received within the outer container. The first end of the inner container has a membrane layer that is pierceable by the mixer when the inner container is received by the outer container to bring the mixer into contact with a test sample in the inner container. The system further includes a test sensor configured for contact with the test sample, and one or more processors for receiving signals from the test sensor following actuation of the mixer to cause mixing of the sample and analyzing the sample based on the signals.

Abstract: Systems and methods are provided for analyzing a test sample is provided. A test sampling apparatus includes a housing extending from a first end to a second end opposite the first end. The housing includes a chamber disposed at the first end. The chamber is configured to receive a test sample from a user. The test sampling apparatus includes a test sensor fluidically coupled to the chamber and disposed within an interior portion of the housing. The test sensor is configured to receive the test sample and generate information based thereon. The information includes data identifying a substance in the test sample. The test sampling apparatus also includes one or more processors disposed within an interior portion of the second end and in communication with the test sensor. The one or more processors receive the information from the test sensor and analyze the test sample based on the information.

Abstract: In one aspect, a sample collection device for collecting a biological sample is disclosed, which comprises a sample-receiving cup having a body that extends from a proximal opening to a distal opening, where the proximal opening is configured for receiving a biological sample. The sample collection device further includes a sensor comprising at least one sensing unit, where the sensor is sealingly connected to the distal opening of the sample-receiving cup such that the sensing unit is exposed to the distal opening. A reservoir for storing one or more sample-processing reagents is provided in the fluid-receiving cup such that the sensing unit is in fluid contact with the reagent(s) stored in the reservoir. A frangible membrane separates the reservoir from the proximal opening.

Abstract: An assay cartridge and an assay reader or other system for running an assay on the assay cartridge. The assay cartridge can be configured to perform different types of diagnostic assays, and the assay reader can be configured to run the specific assay for which the assay cartridge is configured, including PCR assays, immunoassays, and electrochemical bioassays. The assay cartridge can be inserted into the assay reader to run an assay. In some embodiments, the assay reader may have a user interface for configuring the assay reader and displaying results. In other embodiments, a phone or other device with a user interface and a diagnostic assay protocol application can communicate with the assay reader to provide the appropriate protocol instructions to run the assay, to collect and analyze data from the assay reader, and to report and store assay results.

Abstract: The present disclosure provides systems for gel electrophoresis and electrotransfer comprising one or more chambers that can removably and interchangeably receive either an electrophoresis cassette, or an electrotransfer cassette, and provides an electrical interface for both electrophoresis and electrotransfer of biomolecules. The present disclosure also provides electrophoresis devices including clamps and electrotransfer cassettes and related devices. Methods for electrophoresis and electrotransfer using the systems and devices of the disclosure are also provided.

Abstract: An apparatus for preparation of an electrophoresis slab gel may include a base having an opening configured to receive a cassette configured to contain an electrophoresis slab gel, a clamping mechanism configured to move relative to the base between an open position in which the clamping mechanism permits insertion of a cassette into the base, and a closed position in which the clamping mechanism is configured to clamp a cassette received in the base, a compressible pad operatively coupled to the clamping mechanism in a position to compress against a cassette received in the base in the closed position of the clamping mechanism. The cassette may include a first plate and a second plate, and a spacer mechanism separate from each of the first and second plates, the spacer mechanism configured to be positioned between the inner faces of the first plate and the second plate.