Patents by Inventor Kyle Butler

Kyle Butler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIFUNCTIONAL CHEMICAL EPIGENENTIC MODIFIERS AND METHODS OF USE
    Publication number: 20240287492
    Abstract: The present disclosure relates to bifunctional chemical epigenetic modifiers, and methods of making, kits and using the bifunctional chemical epigenetic modifiers. The bifunctional chemical epigenetic modifiers can include a FK506 molecule or derivative thereof, a linker and a bifunctional ligand. The bifunctional ligand can be a histone deacetylase inhibitor.
    Type: Application
    Filed: February 9, 2024
    Publication date: August 29, 2024
    Inventors: Nate Hathaway, Jian Jin, Kyle Butler, Anna Chiarella
  • Bifunction chemical epigenetic modifiers and methods of use
    Patent number: 11905537
    Abstract: The present disclosure relates to bifunctional chemical epigenetic modifiers, and methods of making, kits and using the bifunctional chemical epigenetic modifiers. The bifunctional chemical epigenetic modifiers can include a FK506 molecule or derivative thereof, a linker and a bifunctional ligand. The bifunctional ligand can be a histone deacetylase inhibitor.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: February 20, 2024
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Nate Hathaway, Jian Jin, Kyle Butler, Anna Chiarella
  • Heterochromatin gene repression inhibitors
    Patent number: 11254654
    Abstract: The present disclosure relates to chemical compounds that inhibit HP1-mediated heterochromatin formation, pharmaceutical compositions containing such compounds, methods of identifying such compounds, and their use in the treatment of disorders related to heterochromatin formation such as, for example, a disorder of cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: February 22, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nate Hathaway, Jian Jin, Ian MacDonald, Kyle Butler
  • BIFUNCTION CHEMICAL EPIGENENTIC MODIFIERS AND METHODS OF USE
    Publication number: 20210355476
    Abstract: The present disclosure relates to bifunctional chemical epigenetic modifiers, and methods of making, kits and using the bifunctional chemical epigenetic modifiers. The bifunctional chemical epigenetic modifiers can include a FK506 molecule or derivative thereof, a linker and a bifunctional ligand. The bifunctional ligand can be a histone deacetylase inhibitor.
    Type: Application
    Filed: August 3, 2018
    Publication date: November 18, 2021
    Inventors: Nate Hathaway, Jian Jin, Kyle Butler, Anna Chiarella
  • HETEROCHROMATIN GENE REPRESSION INHIBITORS
    Publication number: 20200181116
    Abstract: The present disclosure relates to chemical compounds that inhibit HP1-mediated heterochromatin formation, pharmaceutical compositions containing such compounds, methods of identifying such compounds, and their use in the treatment of disorders related to heterochromatin formation such as, for example, a disorder of cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: June 29, 2018
    Publication date: June 11, 2020
    Inventors: Nate Hathaway, Jian Jin, Ian MacDonald, Kyle Butler