Patents by Inventor Kyle D. BAUCOM

Kyle D. BAUCOM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of vinyl cyclobutyl intermediates
    Patent number: 12623993
    Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein R1 and OPG2 are described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: May 12, 2026
    Assignee: AMGEN INC.
    Inventors: Austin G. Smith, Michael T. Corbett, Neil Fred Langille, Kyle D. Baucom, Peter K. Dornan, Gabrielle St- Pierre, Philipp C. Roosen, Sheng Cui, Roberto Profeta
  • Ring closing synthesis of macrocyclic MCL-1 inhibitor intermediates
    Patent number: 12441741
    Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: October 14, 2025
    Assignee: AMGEN INC.
    Inventors: Austin G. Smith, Jason S. Tedrow, Gabrielle St-Pierre, Oliver Ralf Thiel, Liang Huang, Philipp C. Roosen, John T. Colyer, Kyle D. Baucom, Ari Ericson, Matthew G. Beaver, Rahul P. Sangodkar, Michael A. Lovette, Robert Ronald Milburn, Alan H. Cherney, Sheng Cui
  • Processes for Making NAG-25, a Carbohydrate Targeting Moiety, and its Intermediates
    Publication number: 20250289842
    Abstract: Provided herein are improved processes for the preparation of a carbohydrate targeting moiety and its intermediates (I).
    Type: Application
    Filed: May 2, 2023
    Publication date: September 18, 2025
    Inventors: Kyle D. BAUCOM, Carolyn Michelle COHEN, Edward HELBLING, Heather Claire JOHNSON, Sharon E. MICHALAK, Philipp C. ROOSEN, Shea J. O'SULLIVAN, Amanda STAHL, Janine K. TOM
  • ENANTIOSELECTIVE ALKENYLATION OF ALDEHYDES
    Publication number: 20240002400
    Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound IA, wherein R1 is described herein. Compound IA can be useful in synthesizing compound A1, or a salt or solvate thereof, and compound A2, or a salt of solvate thereof.
    Type: Application
    Filed: November 23, 2021
    Publication date: January 4, 2024
    Applicant: AMGEN INC.
    Inventors: KYLE D. BAUCOM, MICHAEL T. CORBETT, SHENG CUI, NEIL F. LANGILLE, ANDREAS RENE ROTHELI, ROBERTO PROFETA, AUSTIN G. SMITH
  • Synthesis of Vinyl Cyclobutyl Intermediates
    Publication number: 20230183164
    Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein R1 and OPG2 are described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
    Type: Application
    Filed: May 4, 2021
    Publication date: June 15, 2023
    Applicant: AMGEN INC.
    Inventors: Austin G. SMITH, Michael T. CORBETT, Neil Fred LANGILLE, Kyle D. BAUCOM, Peter K. DORNAN, Gabrielle ST- PIERRE, Philipp C. ROOSEN, Sheng CUI, Roberto PROFETA
  • Ring Closing Synthesis of Macrocyclic MCL-1 Inhibitor Intermediates
    Publication number: 20230167130
    Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.
    Type: Application
    Filed: May 5, 2021
    Publication date: June 1, 2023
    Applicant: AMGEN INC.
    Inventors: Austin G. SMITH, Jason S. TEDROW, Gabrielle ST-PIERRE, Oliver Ralf THIEL, Liang HUANG, Philipp C. ROOSEN, John T. COLYER, Kyle D. BAUCOM, Ari ERICSON, Matthew G. BEAVER, Rahul P. SANGODKAR, Michael A. LOVETTE, Robert Ronald MILBURN, Alan H. CHERNEY, Sheng CUI