Abstract: An engineered immune receptor (e.g., a chimeric antigen receptor (CAR) or chimeric costimulatory receptor (CCR)) that contains one or more short linear motifs that bind to other intracellular signaling proteins are provided, as well as nucleic acids encoding the same, cells that contain the same and methods of use. Examples of such motifs include a PLC?1-binding motifs and TRAF binding motifs, but other motifs may be used. These motifs are thought to recruit other proteins to the engineered immune receptor, thereby altering cellular responses.

Abstract: The present disclosure generally relates to sealing a bonnet in a valve system. Using novel combinations of seals and gaskets, the present systems can prevent fugitive emissions in a high pressure piping system. For example, in certain embodiments, the present systems combine spring energized seals, O-rings, and PTFE spacers in a bonnet to create a gas-tight seal in a fluid transportation system.

Abstract: The present disclosure generally relates to sealing a bonnet in a valve system. Using novel combinations of seals and gaskets, the present systems can prevent fugitive emissions in a high pressure piping system. For example, in certain embodiments, the present systems combine spring energized seals, O-rings, and PTFE spacers in a bonnet to create a gas-tight seal in a fluid transportation system.