Patents by Inventor Kyle Defrees

Kyle Defrees has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic RIP1 kinase inhibitors
    Patent number: 12156880
    Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.
    Type: Grant
    Filed: March 10, 2022
    Date of Patent: December 3, 2024
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Simon Shaw, Somasekhar Bhamidipati, Vanessa Taylor, Kyle Defrees
  • HETEROCYCLIC RIP1 KINASE INHIBITORS
    Publication number: 20220296608
    Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.
    Type: Application
    Filed: March 10, 2022
    Publication date: September 22, 2022
    Inventors: Simon SHAW, Somasekhar BHAMIDIPATI, Vanessa TAYLOR, Kyle DEFREES
  • Compositions, methods of use, and methods of treatment
    Patent number: 10688080
    Abstract: The present disclosure provides compositions including a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: June 23, 2020
    Assignees: UNIVERSITY OF SOUTH FLORIDA, The Regents of the University of California
    Inventors: Yu Chen, Nicholas Joseph Torelli, Orville Antonio Pemberton, Xiujun Zhang, Adam Renslo, Kyle Defrees, Priyadarshini Jaishankar
  • COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT
    Publication number: 20180333390
    Abstract: The present disclosure provides compositions including a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Application
    Filed: July 30, 2018
    Publication date: November 22, 2018
    Inventors: Yu Chen, Nicholas Joseph Torelli, Orville Antonio Pemberton, Xiujun Zhang, Adam Renslo, Kyle Defrees, Priyadarshini Jaishankar