Abstract: The subject matter disclosed herein is generally directed to methods of treating a tumor capable of an epithelial-to-mesenchymal transition (an EMT cancer) by targeting the mesenchymal cell state. Disclosed are novel gene dependencies in the mesenchymal cell state. Also, disclosed are novel drugs that target the mesenchymal cell state.

Abstract: The present disclosure is directed to improved downhole motor designs. In one illustrative embodiment, primary and secondary thrust bearings that are maintained in position by other structural components of the motor without compressive loading of the entire bearing assembly are positioned inside the motor housing for protection from cuttings and debris in the drilling fluid. In some illustrative embodiments, a drive train that features at least one multi-part sectional flex joint may allow for a shortened flex shaft while sufficiently converting eccentric forces from the power source to rotation of the mandrel.

Abstract: A system and method may relate to a broadcasting and content-sharing system. The system may be configured to allow a user to upload, save, record, create, and/or share content with other users of the system. Additionally, users of the system may communicate with one another by, for example, transmitting content between one another, such as audio (e.g., music), video, text, or the like, and/or participating in real-time audio and/or video communication, for example, to collaborate artistically, battle (e.g., take turns singing, rapping, or playing an instrument, trying to best the other participant), view a live (i.e., in real time) or prerecorded performance as an audience member, and/or the like.

Abstract: The present disclosure is directed to improved downhole motor designs. In one illustrative embodiment, primary and secondary thrust bearings that are maintained in position by other structural components of the motor without compressive loading of the entire bearing assembly are positioned inside the motor housing for protection from cuttings and debris in the drilling fluid. In some illustrative embodiments, a drive train that features at least one multi-part sectional flex joint may allow for a shortened flex shaft while sufficiently converting eccentric forces from the power source to rotation of the mandrel.

Abstract: A system and method may relate to a broadcasting and content-sharing system. The system may be configured to allow a user to upload, save, record, create, and/or share content with other users of the system. Additionally, users of the system may communicate with one another by, for example, transmitting content between one another, such as audio (e.g., music), video, text, or the like, and/or participating in real-time audio and/or video communication, for example, to collaborate artistically, battle (e.g., take turns singing, rapping, or playing an instrument, trying to best the other participant), view a live (i.e., in real time) or prerecorded performance as an audience member, and/or the like.

Abstract: The present invention provides improved methods for preparing polysaccharide protein conjugates utilizing surfactants to improve filterability of the conjugation reaction mixture. The polysaccharide-protein conjugates are useful for inclusion in vaccines.

Abstract: Systems and methods for generating a graphical interface and scheduling administrative rounds are presented. The graphical interface may present to an administrator a prioritized list of care providers based on care provider performance, care provider satisfaction, patient satisfaction, and labor data associated with the care provider. A schedule of administrative rounds to counsel the care provider may be presented to the administrator and may be based on the prioritized list, administrator and patient location, and administrator and patient schedule.

Abstract: Systems and methods set forth herein may aid in identifying and disrupting undesirable outcomes. The system may include computer readable media; an electronic input device; an output device; a processor in data communication with the input device and the output device; and electronic instructions. The electronic instructions, when executed by the at least one processor, perform steps for: automatically storing event data from the electronic input device in the computer readable media; actuating the output device to graphically display the event data; determining if the event data qualifies as a critical event; storing the critical event data as outcome data in the computer readable media; accessing the event data and outcome data; determining at least one correlation between the event data and the outcome data; actuating the output device to display an intervention to aid in disrupting future critical events; and storing the intervention in the computer readable media.

Abstract: Systems and methods for generating a graphical interface and scheduling administrative rounds are presented. The graphical interface may present to an administrator a prioritized list of care providers based on care provider performance, care provider satisfaction, patient satisfaction, and labor data associated with the care provider. A schedule of administrative rounds to counsel the care provider may be presented to the administrator and may be based on the prioritized list, administrator and patient location, and administrator and patient schedule.

Abstract: A gaming system selects and displays one of a plurality of symbol blocks in each of a plurality of block positions, wherein each of the selected blocks includes at least one partial symbol. Each partial symbol has at least one complementary partial symbol which, when arranged in a designated spatial relationship with one another, form a complete matching symbol. If any of the partial symbols on the selected blocks create a complete matching symbol, the gaming system provides at least one award to the player. Each matching block which includes any portion of a complete matching symbol is then removed, creating an empty block position. The gaming system then fills the empty block position by either shifting a displayed block into the empty block position or by selecting a new block. The gaming system repeats this process until no complete matching symbols are formed.

Abstract: Media, method, and system are described for generating a graphical user interface presenting care tasks to a care provider. Particularly, embodiments describe sensing a location such as a department, floor, or clinic, retrieving a population of patients, and producing a graphical user interface of care tasks to be performed. In embodiments, the graphical user interface may be generated based on prior performance of the care provider.

Abstract: Systems, modules, and methods set forth herein may allow patient satisfaction to be improved. One system for improving patient satisfaction includes computer readable media, an output device, a processor in data communication with the computer readable media and the output device, and electronic instructions that, when executed by the processor, perform steps for: (a) automatically storing event data from a plurality of electronic devices in the computer readable media; (b) storing perception data obtained from a plurality of patients in the computer readable media; (c) accessing the event data; (d) accessing the perception data; (e) determining at least one correlation between the event data and the perception data; (f) determining at least one proposal to improve patient satisfaction based on the at least one correlation; and (g) actuating the output device to convey the at least one proposal to improve patient satisfaction.

Abstract: A gaming system selects and displays one of a plurality of symbol blocks in each of a plurality of block positions, wherein each of the selected blocks includes at least one partial symbol. Each partial symbol has at least one complementary partial symbol which, when arranged in a designated spatial relationship with one another, form a complete matching symbol. If any of the partial symbols on the selected blocks create a complete matching symbol, the gaming system provides at least one award to the player. Each matching block which includes any portion of a complete matching symbol is then removed, creating an empty block position. The gaming system then fills the empty block position by either shifting a displayed block into the empty block position or by selecting a new block. The gaming system repeats this process until no complete matching symbols are formed.

Abstract: A gaming system selects and displays one of a plurality of symbol blocks in each of a plurality of block positions, wherein each of the selected blocks includes at least one partial symbol. Each partial symbol has at least one complementary partial symbol which, when arranged in a designated spatial relationship with one another, form a complete matching symbol. If any of the partial symbols on the selected blocks create a complete matching symbol, the gaming system provides at least one award to the player. Each matching block which includes any portion of a complete matching symbol is then removed, creating an empty block position. The gaming system then fills the empty block position by either shifting a displayed block into the empty block position or by selecting a new block. The gaming system repeats this process until no complete matching symbols are formed.

Abstract: A gaming system selects and displays one of a plurality of symbol blocks in each of a plurality of block positions, wherein each of the selected blocks includes at least one partial symbol. Each partial symbol has at least one complementary partial symbol which, when arranged in a designated spatial relationship with one another, form a complete matching symbol. If any of the partial symbols on the selected blocks create a complete matching symbol, the gaming system provides at least one award to the player. Each matching block which includes any portion of a complete matching symbol is then removed, creating an empty block position. The gaming system then fills the empty block position by either shifting a displayed block into the empty block position or by selecting a new block. The gaming system repeats this process until no complete matching symbols are formed.

Abstract: A gaming system selects and displays one of a plurality of symbol blocks in each of a plurality of block positions, wherein each of the selected blocks includes at least one partial symbol. Each partial symbol has at least one complementary partial symbol which, when arranged in a designated spatial relationship with one another, form a complete matching symbol. If any of the partial symbols on the selected blocks create a complete matching symbol, the gaming system provides at least one award to the player. Each matching block which includes any portion of a complete matching symbol is then removed, creating an empty block position. The gaming system then fills the empty block position by either shifting a displayed block into the empty block position or by selecting a new block. The gaming system repeats this process until no complete matching symbols are formed.

Abstract: A buffer object for performing intelligent buffering functions in a data acquisition (DAQ) system. The buffer object stores information regarding data to be transferred and includes one or more iterators for performing burst transfers. When a DAQ user application generates a call to perform data transfer operations in the DAQ system, the driver level software creates or instantiates a buffer object. The buffer object includes data format information specifying a format of the data being transferred, including the size of the data, the number of samples per scan, and number of scans of the data. The driver level software also creates a foreground iterator which is executable to transfer data between a client portion of system memory and a buffer portion of system memory. The driver level software also creates a background iterator which is executable to transfer data between a buffer portion of system memory and the on-board memory comprised on the DAQ device.