Patents by Inventor Kyle Furge

Kyle Furge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-8 as a biomarker for sunitinib resistance
    Patent number: 8133686
    Abstract: A method of determining whether a tumor will be non-responsive to sunitinib therapy including detecting whether IL-8 or MMP12 expression levels in the tumor are elevated as compared to a control, that is, a tumor having elevated IL-8 or MMP12 levels will be non-responsive to sunitinib. Also, a method for inhibiting the proliferation or causing the death of a sunitinib-resistant tumor cell by contacting the cell with an agent that inhibits IL-8 or MMP12 activity and with sunitinib, whereby proliferation of the tumor cell is inhibited or the tumor cell dies. Further, the invention includes compositions and kits that include an IL-8 inhibitor or an MMP12 inhibitor and sunitinib, and related methods of treatment.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: March 13, 2012
    Assignee: Van Andel Research Institute
    Inventors: Bin Tean Teh, Dan Huang, Kyle Furge, Richard Kahnoski
  • METHODS FOR TREATING SUNITINIB-RESISTANT CARCINOMA AND RELATED BIOMARKERS
    Publication number: 20090285832
    Abstract: A method of determining whether a tumor will be non-responsive to sunitinib therapy including detecting whether IL-8 or MMP12 expression levels in the tumor are elevated as compared to a control, that is, a tumor having elevated IL-8 or MMP12 levels will be non-responsive to sunitinib. Also, a method for inhibiting the proliferation or causing the death of a sunitinib-resistant tumor cell by contacting the cell with an agent that inhibits IL-8 or MMP12 activity and with sunitinib, whereby proliferation of the tumor cell is inhibited or the tumor cell dies. Further, the invention includes compositions and kits that include an IL-8 inhibitor or an MMP12 inhibitor and sunitinib, and related methods of treatment.
    Type: Application
    Filed: May 15, 2009
    Publication date: November 19, 2009
    Inventors: Bin Tean Teh, Kyle Furge, Dan Huang, Richard Kahnoski