Patents by Inventor Kyle HOGAN

Kyle HOGAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KAURENOIC ACID 13-HYDROXYLASE (KAH) VARIANTS AND USES THEREOF
    Publication number: 20260062683
    Abstract: Provided herein are genetically modified host cells, compositions, and methods for improved production of steviol glycosides. The host cells are genetically modified to contain a heterologous nucleic acid that expresses novel and optimized variants of Ro.KAH. The host cell further contains one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing one or more steviol glycosides in the host cell. The host cells, compositions, and methods described herein provide an efficient route for the heterologous production of steviol glycosides including rebaudioside A, rebaudioside D, and rebaudioside M.
    Type: Application
    Filed: June 30, 2025
    Publication date: March 5, 2026
    Inventors: Andrew P. KLEIN, Sean LUND, Gale WICHMANN, Irina KORYAKINA, Kyle HOGAN, Svetlana BORISOVA
  • Kaurenoic acid 13-hydroxylase (KAH) variants and uses thereof
    Patent number: 12467039
    Abstract: Provided herein are genetically modified host cells, compositions, and methods for improved production of steviol glycosides. The host cells are genetically modified to contain a heterologous nucleic acid that expresses novel and optimized variants of Ro.KAH. The host cell further contains one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing one or more steviol glycosides in the host cell. The host cells, compositions, and methods described herein provide an efficient route for the heterologous production of steviol glycosides including rebaudioside A, rebaudioside D, and rebaudioside M.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: November 11, 2025
    Assignee: Amyris, Inc.
    Inventors: Andrew P. Klein, Sean Lund, Gale Wichmann, Irina Koryakina, Kyle Hogan, Svetlana Borisova
  • COMPOSITIONS AND METHODS FOR IMPROVED PRODUCTION OF STEVIOL GLYCOSIDES
    Publication number: 20250320538
    Abstract: Provided herein are variant uridine-5?-diphosphate glycosyltransferase polypeptides capable of producing steviol glycosides, yeast cells capable of producing steviol glycosides, and methods of making such cells. Also provided are fermentation compositions including the disclosed host cells, and related methods of producing and recovering steviol glycosides generated by the yeast cells.
    Type: Application
    Filed: May 18, 2023
    Publication date: October 16, 2025
    Inventors: Svetlana BORISOVA, Kyle HOGAN, Alexander KILBO, Gale WICHMANN, Yi XIONG
  • KAURENOIC ACID 13-HYDROXYLASE (KAH) VARIANTS AND USES THEREOF
    Publication number: 20220282228
    Abstract: Provided herein are genetically modified host cells, compositions, and methods for improved production of steviol glycosides. The host cells are genetically modified to contain a heterologous nucleic acid that expresses novel and optimized variants of Ro.KAH. The host cell further contains one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing one or more steviol glycosides in the host cell. The host cells, compositions, and methods described herein provide an efficient route for the heterologous production of steviol glycosides including rebaudioside A, rebaudioside D, and rebaudioside M.
    Type: Application
    Filed: May 1, 2020
    Publication date: September 8, 2022
    Inventors: Andrew P. KLEIN, Sean LUND, Gale WICHMANN, Irina KORYAKINA, Kyle HOGAN, Svetlana BORISOVA