Patents by Inventor Kyle Jacoby

Kyle Jacoby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRIMARY CELL GENE EDITING
    Publication number: 20200165634
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Application
    Filed: February 5, 2020
    Publication date: May 28, 2020
    Applicant: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • Primary cell gene editing
    Patent number: 10584357
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: March 10, 2020
    Assignee: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • Primary cell gene editing
    Patent number: 10550406
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: February 4, 2020
    Assignee: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • PRIMARY CELL GENE EDITING
    Publication number: 20190376086
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Application
    Filed: August 27, 2019
    Publication date: December 12, 2019
    Applicant: PACT PHARMA, INC.
    Inventors: KYLE JACOBY, ALEX FRANZUSOFF
  • PRIMARY CELL GENE EDITING
    Publication number: 20190376091
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Application
    Filed: August 27, 2019
    Publication date: December 12, 2019
    Applicant: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • NOVEL RNA-BASED VECTOR SYSTEM FOR TRANSIENT AND STABLE GENE EXPRESSION
    Publication number: 20180327781
    Abstract: The present application generally compositions comprising a synthetic delivery RNA comprising a first sequence from a viral genome and/or a second sequence from a viral genome and wherein the synthetic delivery RNA further comprises a nucleic acid sequence encoding a gene. The application further relates to methods of using the composition for delivering a nucleic acid to a nucleus of a cell disclosed herein. The application further relates to methods of treating, inhibiting, or ameliorating a disease in a subject including administering to the subject a cell disclosed herein.
    Type: Application
    Filed: November 8, 2016
    Publication date: November 15, 2018
    Inventors: Andrew M. Scharenberg, Michelle Christian, Kyle Jacoby
  • LONG POLY(A) PLASMIDS AND METHODS FOR INTRODUCTION OF LONG POLY(A) SEQUENCES INTO THE PLASMID
    Publication number: 20180272007
    Abstract: Disclosed herein are polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, methods of engineering the polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, and methods of enhancing transcription, translation, and increasing stability of a polynucleotide.
    Type: Application
    Filed: April 11, 2018
    Publication date: September 27, 2018
    Inventors: Andrew M. Scharenberg, Kyle Jacoby, Alexandra E. Grier
  • Long poly(A) plasmids and methods for introduction of long poly(A) sequences into the plasmid
    Patent number: 9943612
    Abstract: Disclosed herein are polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, methods of engineering the polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, and methods of enhancing transcription, translation, and increasing stability of a polynucleotide.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: April 17, 2018
    Assignee: Seattle Children's Hospital
    Inventors: Andrew M. Scharenberg, Kyle Jacoby, Alexandra E. Grier
  • LONG POLY(A) PLASMIDS AND METHODS FOR INTRODUCTION OF LONG POLY(A) SEQUENCES INTO THE PLASMID
    Publication number: 20160243258
    Abstract: Disclosed herein are polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, methods of engineering the polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, and methods of enhancing transcription, translation, and increasing stability of a polynucleotide.
    Type: Application
    Filed: October 8, 2015
    Publication date: August 25, 2016
    Inventors: Andrew M. Scharenberg, Kyle Jacoby, Alexandra E. Grier