Abstract: The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amount of compound of the formula and pharmaceutically acceptable salts, solvates, and hydrates thereof to the patient. The variables, e.g. ring A, n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful inhibiting the conversion of glyoxylate to oxalate. When administered to a patient having a disease or disorder associated with elevated oxalate levels, such as PH type 1, type 2, or type 3 or idiopathic hyperoxaluria the compounds prevent or substantially reduce the amount and buildup of oxalate the patient's kidneys, bladder, urinary tract and other parts of the patient's body.

Abstract: A portable pump facility, pump facilities systems, and system to monitor and control a centrifugal pump include a controller configured to receive pressure and speed data from a centrifugal pump and automatically adjust the speed of an engine which drives the pump to control cavitation of the pump and to also optimize load balancing of fluid among pumping facilities. Multiple pumping facilities are provided and communicate for efficient fluid delivery, and include remote control monitoring and operation.