Patents by Inventor Kyle MacBeth

Kyle MacBeth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9808451
    Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: November 7, 2017
    Assignee: Celgene Corporation
    Inventors: Brian E. Cathers, Matthew Daniel Correa, Joshua Hansen, Antonia Lopez-Girona, Ehab M. Khalil, Kyle MacBeth, Hon-Wah Man, George W. Muller, Michael Pourdehnad, Raj Raheja
  • Publication number: 20170007590
    Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.
    Type: Application
    Filed: September 23, 2016
    Publication date: January 12, 2017
    Inventors: Brian E. Cathers, Matthew Daniel Correa, Joshua Hansen, Antonia Lopez-Girona, Ehab M. Khalil, Kyle MacBeth, Hon-Wah Man, George W. Muller, Michael Pourdehnad, Raj Raheja
  • Patent number: 9499514
    Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: November 22, 2016
    Assignee: Celgene Corporation
    Inventors: Joshua Hansen, Matthew Daniel Correa, Raj Raheja, Antonia Lopez-Girona, Hon-Wah Man, George W. Muller, Ehab M. Khalil, Kyle MacBeth, Brian E. Cathers, Michael Pourdehnad
  • Publication number: 20160313300
    Abstract: Provided herein, in some embodiments, are methods of using certain cereblon-associated proteins, such as Aiolos, Ikaros, interferon (IFN), and IFN pathway proteins, casein kinase 1, alpha 1 (CSNK1A1), and ZFP9, as biomarkers for use in predicting and monitoring clinical sensitivity and therapeutic response to certain compounds in patients having various diseases and disorders, such as cancers (e.g., diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM), myelodysplasia syndromes (MDS) and acute myeloid leukemia (AML)) and IFN-associated disorders. Also provided herein, in certain embodiments, are methods of determining the efficacy of an immunomodulatory compound.
    Type: Application
    Filed: December 5, 2014
    Publication date: October 27, 2016
    Inventors: Matthew William Burnell Trotter, Patrick Hagner, Courtney G. Havens, Rajesh Chopra, Anita Gandhi, Anke Klippel, Maria Yinglin Wang, Mike Breider, Suzana Sturlini Couto, Yan Ren, Paul Hollenbach, Kyle MacBeth
  • Publication number: 20080113399
    Abstract: The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 15, 2008
    Inventors: Rosana Kapeller-Libermann, David White, Keith Robison, Kyle MacBeth, Joseph Carroll, William Cook, Rachel Meyers, Miyoung Chun, Mark Williamson
  • Publication number: 20080108093
    Abstract: The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Inventors: Rosana Kapeller-Libermann, David White, Keith Robison, Kyle MacBeth, Joseph Carroll, William Cook, Rachel Meyers, Miyoung Chun, Mark Williamson
  • Publication number: 20080051322
    Abstract: The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.
    Type: Application
    Filed: June 5, 2007
    Publication date: February 28, 2008
    Inventors: Maria Glucksmann, Nadine Weich, John Hunter, David White, Kyle MacBeth, Mark Williamson, Rachel Meyers, Miyoung Chun
  • Publication number: 20080027147
    Abstract: The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: April 11, 2007
    Publication date: January 31, 2008
    Inventors: Rachel Meyers, Mark Williamson, Kevin Leiby, Rosana Kepeller-Libermann, Peter Olandt, Kyle MacBeth, Laura Rodolph-Owen, Fong-Ying Tsai, John Hunter
  • Publication number: 20070087375
    Abstract: The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 genes in tissues relating to cancer, relative to their expression in normal, or non-cancer disease states, and/or in response to manipulations relevant to a cancer. The present invention describes methods for the diagnostic evaluation and prognosis of various cancers, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a cancer or cancer. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cancer.
    Type: Application
    Filed: December 5, 2006
    Publication date: April 19, 2007
    Inventors: John Hunter, Mark Williamson, Kyle MacBeth, Laura Rudolph-Owen, Fong-Ying Tsai
  • Publication number: 20070078088
    Abstract: The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480, 20893, 33230, 1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 and 66428 genes in tissues relating to cancer, relative to their expression in normal, or non-cancer disease states, and/or in response to manipulations relevant to a cancer. The present invention describes methods for the diagnostic evaluation and prognosis of various cancers, and for the identification of subjects exhibiting a predisposition to such conditions.
    Type: Application
    Filed: November 22, 2006
    Publication date: April 5, 2007
    Inventors: John Hunter, Kyle MacBeth, Fong-Ying Tsai, Andrea Lesoon, Eric Lightcap, Mark Williamson, Laura Rudolph-Owen
  • Publication number: 20070065848
    Abstract: The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies.
    Type: Application
    Filed: July 26, 2006
    Publication date: March 22, 2007
    Inventors: Rachel Meyers, Kyle MacBeth, Rory Curtis, Laura Rudolph-Owen, Nadine Weich, Peter Olandt, Fong-Ying Tsai, Rosana Kapeller-Libermann, Joseph Carroll
  • Publication number: 20070009433
    Abstract: The invention provides isolated nucleic acids molecules, designated 14094 nucleic acid molecules, which encode a novel trypsin family member. Elevated expression of 14094 mRNA was detected in breast, ovarian, lung, and liver cancers compared to normal cells derived from these tissues. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14094 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14094 gene has been introduced or disrupted. The invention still further provides isolated 14094 proteins, fusion proteins, antigenic peptides and anti-14094 antibodies. Therapeutic and diagnostic methods utilizing compositions of the invention to, for example, treat, prevent, and/or diagnose neoplastic conditions, are also provided.
    Type: Application
    Filed: April 13, 2006
    Publication date: January 11, 2007
    Inventors: Rachel Meyers, Kyle MacBeth
  • Publication number: 20060088907
    Abstract: The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 gene has been introduced or disrupted.
    Type: Application
    Filed: February 20, 2003
    Publication date: April 27, 2006
    Inventors: Rachel Meyers, Mark Williamson, Rosana Kapeller-Libermann, Kyle MacBeth, John Hunter, Laura Rudolph-Owen, Rajasekhar Bandaru, Fong-Ying Tsai
  • Publication number: 20060009632
    Abstract: The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: September 14, 2005
    Publication date: January 12, 2006
    Inventors: Rosana Kapeller-Libermann, David White, Keith Robison, Kyle MacBeth, Joseph Carroll, William Cook, Rachel Meyers, Miyoung Chun, Mark Williamson
  • Publication number: 20020115839
    Abstract: The invention provides isolated nucleic acids molecules, designated HGT-1 nucleic acid molecules, which encode novel galactosyltransferase family molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HGT-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an HGT-1 gene has been introduced or disrupted. The invention still further provides isolated HGT-1 polypeptides, fusion polypeptides, antigenic peptides and anti-HGT-1 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: August 31, 2001
    Publication date: August 22, 2002
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Rachel Meyers, Kyle MacBeth, Fong-Ying Tsai
  • Publication number: 20020115120
    Abstract: Novel HKID-1 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length HKID-1 proteins, the invention further provides isolated HKID-1 fusion proteins, antigenic peptides and anti-HKID-1 antibodies. The invention also provides HKID-1 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an HKID-1 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: October 4, 2001
    Publication date: August 22, 2002
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Rosana Kapeller-Libermann, Laura A. Rudolph-Owen, Kyle MacBeth
  • Publication number: 20020107376
    Abstract: The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, or 58764 nucleic acid molecules, which encode novel transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, or 58764 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, or 58764 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, or 58764 proteins, fusion proteins, antigenic peptides and anti-26199, -33530, -33949, -47148, -50226, or -58764 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: August 6, 2001
    Publication date: August 8, 2002
    Inventors: Rachel Meyers, Kyle MacBeth
  • Publication number: 20020086302
    Abstract: The present invention relates to methods and compositions for the diagnosis and treatment of bone associated or cellular proliferative or differentiative disease. Specifically, the present invention identifies 17906 genes which are differentially expressed in bone associated or cellular proliferative or differentiative disease states, relative to their expression in normal, or non-bone associated or non-cellular proliferative or differentiative disease states, and/or in response to manipulations relevant to bone associated or cellular proliferative or differentiative disease. The present invention describes methods for the diagnostic evaluation and prognosis of various bone associated or cellular proliferative or differentiative diseases, and for the identification of subjects exhibiting a predisposition to such conditions.
    Type: Application
    Filed: May 16, 2001
    Publication date: July 4, 2002
    Inventors: David White, Kyle MacBeth