Abstract: A brachytherapy device for the provision of brachytherapy is disclosed. The brachytherapy device has at least one source lumen located outside a movable surface of the device. The source lumen may be secured to the movable outer surface in a manner whereby relative movement of the source lumen relative to the movable outer surface is permitted. The brachytherapy device is inserted into a body cavity. After insertion, the movable surface is moved to position the at least one source lumen closer to the tissue boundary of the cavity. One or more sources of radiation are then placed within the at least one source lumen to provide a customizable treatment. Also disclosed are methods for providing brachytherapy via body cavities.

Abstract: A brachytherapy device for the provision of brachytherapy is disclosed. The brachytherapy device has at least one source lumen located outside a movable surface of the device. The source lumen may be secured to the movable outer surface in a manner whereby relative movement of the source lumen relative to the movable outer surface is permitted. The brachytherapy device is inserted into a body cavity. After insertion, the movable surface is moved to position the at least one source lumen closer to the tissue boundary of the cavity. One or more sources of radiation are then placed within the at least one source lumen to provide a customizable treatment. Also disclosed are methods for providing brachytherapy via body cavities.

Abstract: Brachytherapy devices are provided for delivering a substantially uniform dose rate of radiation to a treatment area at a predetermined treatment depth. The devices include a holder defining a cavity, and a radioactive material located within the cavity. The holder comprises radiation-shielding material therein. The holder and the radioactive material are positioned to cooperatively provide a substantially uniform dose rate of radiation to a treatment area at a predetermined treatment depth. Also disclosed are methods for treating macular degeneration or ocular melanoma. The methods involve positioning a brachytherapy device in contact with or in close proximity to tissue located in a treatment area and exposing the tissue located in the treatment area to a therapeutic dose of radiation, which is delivered at a substantially uniform dose rate over the treatment area at a predetermined treatment depth.

Abstract: A brachytherapy device for the provision of brachytherapy is disclosed. The brachytherapy device has at least one source lumen located outside a movable surface of the device. The source lumen may be secured to the movable outer surface in a manner whereby relative movement of the source lumen relative to the movable outer surface is permitted. The brachytherapy device is inserted into a body cavity. After insertion, the movable surface is moved to position the at least one source lumen closer to the tissue boundary of the cavity. One or more sources of radiation are then placed within the at least one source lumen to provide a customizable treatment. Also disclosed are methods for providing brachytherapy via body cavities.

Abstract: Brachytherapy devices are provided for delivering a substantially uniform dose rate of radiation to a treatment area at a predetermined treatment depth. The devices include a holder defining a cavity, and a radioactive material located within the cavity. The holder comprises radiation-shielding material therein. The holder and the radioactive material are positioned to cooperatively provide a substantially uniform dose rate of radiation to a treatment area at a predetermined treatment depth. Also disclosed are methods for treating macular degeneration or ocular melanoma. The methods involve positioning a brachytherapy device in contact with or in close proximity to tissue located in a treatment area and exposing the tissue located in the treatment area to a therapeutic dose of radiation, which is delivered at a substantially uniform dose rate over the treatment area at a predetermined treatment depth.