Patents by Inventor Kyle Minch

Kyle Minch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Interferon alpha-2 variants
    Patent number: 12421288
    Abstract: Provided herein are human interferon alpha-2 (IFNA2) variants that have decreased or no detectable binding to the human interferon-alpha/beta receptor beta 2 (IFNAR2) as compared to the wild-type human IFNA2 polypeptide. Also provided herein are fusion proteins comprising an antibody or fragment thereof, and a human IFNA2 variant, wherein the IFNA2 variant is covalently linked to the antibody, and wherein the IFNA2 variant has decreased or no detectable binding to the human interferon-alpha/beta receptor beta (IFNAR2) as compared to the wild-type human IFNA2 polypeptide.
    Type: Grant
    Filed: March 15, 2024
    Date of Patent: September 23, 2025
    Assignee: A-Alpha Bio
    Inventors: Emily Engelhart, Davis Goodnight, Kyle Minch, Ryan Swanson
  • INTERFERON ALPHA-2 VARIANTS
    Publication number: 20240309062
    Abstract: Provided herein are human interferon alpha-2 (IFNA2) variants that have decreased or no detectable binding to the human interferon-alpha/beta receptor beta 2 (IFNAR2) as compared to the wild-type human IFNA2 polypeptide. Also provided herein are fusion proteins comprising an antibody or fragment thereof, and a human IFNA2 variant, wherein the IFNA2 variant is covalently linked to the antibody, and wherein the IFNA2 variant has decreased or no detectable binding to the human interferon-alpha/beta receptor beta (IFNAR2) as compared to the wild-type human IFNA2 polypeptide.
    Type: Application
    Filed: March 15, 2024
    Publication date: September 19, 2024
    Inventors: Emily Engelhart, Davis Goodnight, Kyle Minch, Ryan Swanson