Abstract: This invention relates generally to an ultrasound device configured to generate a frustum-shaped beam capable of fragmenting a plurality of biomineralizations located within a patient's body in combination with synthetic cavitation nuclei. The ultrasound device includes a transducer assembly comprising a plurality of ultrasound transducer elements, and a multi-channel amplifier circuit. Each channel of the multi-channel amplifier circuit is configured to actuate a distinct subset of the plurality of transducer elements. The multi-channel amplifier circuit is configured to operate in each of a plurality of states, each state of comprising a set of frequencies at which each channel of the multi-channel amplifier circuit is configured to actuate the distinct subset of transducer elements. The multi-channel amplifier circuit is further configured to switch between the plurality of states, thereby causing the plurality of ultrasound transducer elements to produce a frustum-shaped beam.