Patents by Inventor Kyle Quasdorf

Kyle Quasdorf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salts and crystal forms of omecamtiv mecarbil
    Patent number: 11926592
    Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
    Type: Grant
    Filed: September 2, 2022
    Date of Patent: March 12, 2024
    Assignee: Amgen Inc.
    Inventors: Henry Morrison, Sheng Cui, Kyle Quasdorf, Evelyn Yanez, Bin Peter Quan, Ron C. Kelly, Sebastien Caille, Lingyun Xiao, David Pearson, Jaclyn Raeburn, Alisa Golightly
  • PROCESS FOR PREPARING 7-CHLORO-6-FLUORO-1-(2-ISOPROPYL-4-METHYLPYRIDIN-3-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE
    Publication number: 20240025896
    Abstract: Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes [Insert Structure] (Compound A).
    Type: Application
    Filed: November 19, 2021
    Publication date: January 25, 2024
    Applicant: AMGEN INC.
    Inventors: Michal ACHMATOWICZ, John T. COYLER, Michael T. CORBETT, Daniel J. GRIFFIN, Andrew T. PARSONS, Joanna ROBINSON, Kyle QUASDORF
  • SYNTHESIS OF OMECAMTIV MECARBIL
    Publication number: 20230373955
    Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
    Type: Application
    Filed: July 26, 2023
    Publication date: November 23, 2023
    Inventors: Sebastien CAILLE, Kyle QUASDORF, Philipp C. ROOSEN, Xianqing SHI, Andrew COSBIE, Fang WANG, Zufan WU, Archana NEERGUNDA, Bin Peter QUAN, Lianxiu GUAN
  • Synthesis of omecamtiv mecarbil
    Patent number: 11753394
    Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: September 12, 2023
    Assignee: AMGEN INC.
    Inventors: Sebastien Caille, Kyle Quasdorf, Philipp C. Roosen, Xianqing Shi, Andrew Cosbie, Fang Wang, Zufan Wu, Archana Neergunda, Bin Peter Quan, Lianxiu Guan
  • Synthesis of omecamtiv mecarbil
    Patent number: 11702380
    Abstract: Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: July 18, 2023
    Assignee: Amgen Inc.
    Inventors: Sebastien Caille, James Murray, Kyle Quasdorf, Hannah Nguyen, Maria Victoria Silva Elipe, Ari Elizabeth Ericson
  • SALTS AND CRYSTAL FORMS OF OMECAMTIV MECARBIL
    Publication number: 20230108971
    Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
    Type: Application
    Filed: September 2, 2022
    Publication date: April 6, 2023
    Inventors: Henry Morrison, Sheng Cui, Kyle Quasdorf, Evelyn Yanez, Bin Peter Quan, Ron C. Kelly, Sebastien Caille, Lingyun Xiao, David Pearson, Jaclyn Raeburn, Alisa Golightly, Bradley Morgan, Matthew Peterson, Alex Eberlin, Alexander Oblezov
  • Salts and crystal forms of omecamtiv mecarbil
    Patent number: 11465969
    Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: October 11, 2022
    Assignees: CYTOKINETICS, INC., AMGEN INC.
    Inventors: Henry Morrison, Sheng Cui, Kyle Quasdorf, Evelyn Yanez, Bin Peter Quan, Ron C. Kelly, Sebastien Caille, Lingyun Xiao, David Pearson, Jaclyn Raeburn, Ailsa Golightly, Bradley Morgan, Matthew Peterson, Alex Eberlin, Alexander Oblezov
  • SYNTHESIS OF OMECAMTIV MECARBIL
    Publication number: 20220298099
    Abstract: Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.
    Type: Application
    Filed: March 9, 2022
    Publication date: September 22, 2022
    Inventors: Sebastien CAILLE, James MURRAY, Kyle QUASDORF, Hannah NGUYEN, Maria Victoria SILVA ELIPE, Ari Elizabeth ERICSON
  • SYNTHESIS OF OMECAMTIV MECARBIL
    Publication number: 20210371397
    Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
    Type: Application
    Filed: May 19, 2021
    Publication date: December 2, 2021
    Inventors: Sebastien Caille, Kyle Quasdorf, Philipp C. Roosen, Xianqing Shi, Andrew Cosbie, Fang Wang, Zufan Wu, Archana Neergunda, Bin Peter Quan, Lianxiu Guan
  • SALTS AND CRYSTAL FORMS OF OMECAMTIV MECARBIL
    Publication number: 20210221771
    Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
    Type: Application
    Filed: August 16, 2019
    Publication date: July 22, 2021
    Inventors: Henry Morrison, Sheng Cui, Kyle Quasdorf, Evelyn Yanez, Bin Peter Quan, Ron C. Kelly, Sebastien Caille, Lingyun Xiao, David Pearson, Jaclyn Raeburn, Ailsa Golightly, Bradley Morgan, Matthew Peterson, Alex Eberlin, Alexander Oblezov
  • Synthesis of omecamtiv mecarbil
    Patent number: 11040956
    Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: June 22, 2021
    Assignee: AMGEN INC.
    Inventors: Sebastien Caille, Kyle Quasdorf, Philipp Roosen, Xianqing Shi, Andrew Cosbie, Fang Wang, Zufan Wu, Archana Neergunda, Bin Peter Quan, Lianxiu Guan
  • SYNTHESIS OF OMECAMTIV MECARBIL
    Publication number: 20200308143
    Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
    Type: Application
    Filed: June 29, 2018
    Publication date: October 1, 2020
    Inventors: Sebastien Caille, Kyle Quasdorf, Philipp Roosen, Xianqing Shi, Andrew Cosbie, Fang Wang, Zufan Wu, Archana Neergunda, Bin Peter Quan, Lianxiu Guan