Patents by Inventor Kyle R. Pomraning

Kyle R. Pomraning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACONITIC ACID EXPORTER (AEXA) INCREASES ORGANIC ACID PRODUCTION IN ASPERGILLUS
    Publication number: 20240076700
    Abstract: Recombinant Aspergillus genetically modified to increase expression of g8846, renamed herein as aconitic acid exporter (aexA), are provided, which in some examples are also genetically inactivated for an endogenous cis-aconitic acid decarboxylase (cadA) gene. Such recombinant Aspergillus produce more aconitic acid as compared to native Aspergillus. Also provided are methods of using such recombinant Aspergillus to increase production of aconitic acid and other organic acids, such as citric acid, itaconic acid, and 3-hydroxypropionic acid (3-HP).
    Type: Application
    Filed: October 24, 2023
    Publication date: March 7, 2024
    Applicant: Battelle Memorial Institute
    Inventors: Shuang Deng, Jon K. Magnuson, Joonhoon Kim, Kyle R. Pomraning, Ziyu Dai, Beth A. Hofstad
  • PROCESS CONTROL FOR 3-HYDROXYPROPIONIC ACID PRODUCTION BY ENGINEERED STRAINS OF ASPERGILLUS NIGER
    Publication number: 20240052382
    Abstract: Provided herein are recombinant Aspergillus niger capable of producing 3-hydroxypropionic acid (3-HP). Also provided are methods of producing 3-hydroxypropionic acid (3-HP) and related kits.
    Type: Application
    Filed: August 3, 2023
    Publication date: February 15, 2024
    Inventors: Kyle R. Pomraning, Ziyu Dai, Jon K. Magnuson, Beth A. Hofstad, Jeffrey J. Czajka, Joonhoon Kim, Shuang Deng
  • Aconitic acid exporter (aexA) increases organic acid production in
    Patent number: 11873523
    Abstract: Recombinant Aspergillus genetically modified to increase expression of g8846, renamed herein as aconitic acid exporter (aexA), are provided, which in some examples are also genetically inactivated for an endogenous cis-aconitic acid decarboxylase (cadA) gene. Such recombinant Aspergillus produce more aconitic acid as compared to native Aspergillus. Also provided are methods of using such recombinant Aspergillus to increase production of aconitic acid and other organic acids, such as citric acid, itaconic acid, and 3-hydroxypropionic acid (3-HP).
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: January 16, 2024
    Assignee: Battelle Memorial Institute
    Inventors: Shuang Deng, Jon K. Magnuson, Joonhoon Kim, Kyle R. Pomraning, Ziyu Dai, Beth A. Hofstad
  • ACONITIC ACID EXPORTER (AEXA) INCREASES ORGANIC ACID PRODUCTION IN ASPERGILLUS
    Publication number: 20210388399
    Abstract: Recombinant Aspergillus genetically modified to increase expression of g8846, renamed herein as aconitic acid exporter (aexA), are provided, which in some examples are also genetically inactivated for an endogenous cis-aconitic acid decarboxylase (cadA) gene. Such recombinant Aspergillus produce more aconitic acid as compared to native Aspergillus. Also provided are methods of using such recombinant Aspergillus to increase production of aconitic acid and other organic acids, such as citric acid, itaconic acid, and 3-hydroxypropionic acid (3-HP).
    Type: Application
    Filed: June 14, 2021
    Publication date: December 16, 2021
    Applicant: Battelle Memorial Institute
    Inventors: Shuang Deng, Jon K. Magnuson, Joonhoon Kim, Kyle R. Pomraning, Ziyu Dai, Beth A. Hofstad