Abstract: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit includes a charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers directly into the at least one charge carrier storage region based upon times at which the charge carriers are produced.

Abstract: Heat transfer systems and methods are generally described. A bioanalytical instrument may employ a variety of heat-generating optoelectronic chips to perform biochemical assays. In some embodiments, the instrument may include a heat transfer system configured to cool the chips by thermally coupling them to a heat sink. The heat transfer system may include an elastically deformable flexible plate to conform to the differently-sized chips, withstand numerous cycles of chip insertion/removal, and respond to pressures exerted by supporting structures of the instrument. The heat transfer system may include a thermally conductive material indirectly but thermally coupled to the chip via the flexible plate, which may be positioned between the heat sink and the flexible plate.