Abstract: Medical imaging reconstruction of a subject's anatomy may include: monitoring first and second medical imaging data of the subject's anatomy, wherein: the first medical imaging data is captured from within the subject's anatomy by at least one first medical imaging device; the second medical imaging data is captured from outside of the subject's anatomy by at least one second medical imaging device; and at least one of the first medical imaging device or the second medical imaging device is operable to selectively target different regions of the subject's anatomy; and in response to detecting, based on the monitoring, a divergence in the first medical imaging data and the second medical imaging data above a predetermined threshold, updating a medical imaging reconstruction of the subject's anatomy that is based on the first medical imaging data and the second medical imaging data.

Abstract: Medical systems are described, including a medical system includes a first medical device and a second medical device. The first medical device includes a handle and an insertion portion with a first working channel. A distal portion of the insertion portion of the first medical device includes a first tracking element and at least one camera. The second medical device includes a handle and an insertion portion. A distal portion of the insertion portion of the second medical device includes a second tracking element. The first tracking element is configured to provide a signal that indicates a position or orientation of the distal portion of the first medical device. The second tracking element is configured to provide a signal that indicates a position or orientation of the distal portion of the second medical device.

Abstract: A medical assembly may comprise: a substrate configured to be disposed in a body at a distal tip of a medical device; and a position sensing system, including a magnetic field sensor mounted to the substrate. The magnetic field sensor may be configured to provide a signal that indicates a position or orientation of the distal tip of the medical device. The medical assembly may further comprise at least one camera mounted to the substrate; and at least one lighting element mounted to the substrate.

Abstract: A method of providing in vivo navigation of a medical device includes: receiving input medical imaging data of a patient's anatomy; receiving input non-optical in vivo image data from a sensor on a distal end of the device in the anatomy; using a trained model to locate the distal end in the input imaging data, wherein: the model is trained, based on (i) training medical imaging data and training non-optical in vivo image data of one or more individuals' anatomy and (ii) registration data associating the training image data with locations in the training imaging data as ground truth, to learn associations between the training image data and the training imaging data; determining an output location of the medical device using the learned associations and the input data; modifying the input imaging data to depict the determined location; and causing a display to output the modified input imaging data.

Abstract: The disclosure relates to localizing medical devices within a body lumen, such as for identifying the location of, or navigating to, a target tissue. Embodiments include localizing a medical device extended out of a working channel of a delivery device. The medical device may include an imaging sensor, such as for mapping the body lumen. In many embodiments, a delivery device may include one or more sensors including a first sensor to interact with a tracking system to determine the location of the delivery device within a tracking volume and a second sensor to determine the location of the medical device relative to the delivery device. In many such embodiments, a controller may determine the location of the medical device in the tracking volume based on the location of the delivery device in the tracking volume and the location of the medical device with respect to the delivery device.

Abstract: The present disclosure includes elongate members for positioning medical devices at a target site within a body lumen. In various embodiments, the elongate member may include one or more articulation joints for maneuvering, one or more transducers for localizing, and one or more lumens for delivering instruments to the target site. Some embodiments are particularly directed to a medical device that guides an operator to a target site, confirms the location of the target site, and enables a biopsy to be taken from and/or a therapy to be delivered to the target site. For example, a position tracking sensor may be utilized to guide the medical device to the target site, a phased array sensor may be utilized to confirming proper positioning at the target site, and a biopsy needle inserted through a lumen may be utilized to acquire a sample from the target site.

Abstract: A treatment system includes a fluid cooling supply system for chilling and delivering liquid coolant to a patient. The fluid cooling supply system includes a cooling device and a heat exchanger device. The heat exchanger device is biased to the cooling device and is in fluid communication with a treatment device in a patient. The fluid cooling supply system includes at least one biasing mechanism to provide a given biasing force between the heat exchanger device and the cooling device to effectuate and improve heat transfer. The liquid coolant may be circulated through an energy delivery device positioned in an airway of a patient to preserve tissue. The system is controlled to circulate liquid coolant at a given temperature and pressure for a selected amount of time during pulmonary treatment of a patient.

Abstract: A treatment system includes a fluid cooling supply system for chilling and delivering liquid coolant to a patient. The fluid cooling supply system includes a cooling device and a heat exchanger device. The heat exchanger device is biased to the cooling device and is in fluid communication with a treatment device in a patient. The fluid cooling supply system includes at least one biasing mechanism to provide a given biasing force between the heat exchanger device and the cooling device to effectuate and improve heat transfer. The liquid coolant may be circulated through an energy delivery device positioned in an airway of a patient to preserve tissue. The system is controlled to circulate liquid coolant at a given temperature and pressure for a selected amount of time during pulmonary treatment of a patient.

Abstract: An implantable cardiac rhythm management (CRM) system for directing stimulation energy toward a target tissue and away from unwanted tissues for providing an appropriate stimulation is provided by the present invention. The implantable cardiac rhythm management (CRM) system includes an implantable lead. The implantable lead includes a lead body and an electrically insulating member. The lead body includes at least one electrode extending substantially around the lead body. The electrically insulating member defines at least one window. At least one insulating member includes a protruding portion configured to urge at least one electrode toward the target tissue.

Abstract: A neurostimulation lead includes a lead body having a proximal portion and a distal portion and a first conductor extending through the lead body. An electrode cuff can be secured relative to the distal portion of the lead body. The electrode cuff includes a cuff body, a first tendril extending from a first region of the cuff body, a second tendril extending from a second region of the cuff body and a first electrode disposed on the cuff body and electrically connected to the first conductor.

Abstract: A neurostimulation lead includes a lead body having a proximal portion and a distal portion and a first conductor extending through the lead body. An electrode cuff can be secured relative to the distal portion of the lead body. The electrode cuff includes a cuff body, a first tendril extending from a first region of the cuff body, a second tendril extending from a second region of the cuff body and a first electrode disposed on the cuff body and electrically connected to the first conductor.

Abstract: The present invention provides a cuff electrode assembly for implantation on a target nerve. The cuff electrode assembly can include a resilient cuff body configured to be disposed about the target nerve. The cuff body includes a first end portion having a first free end, and a second end portion having a second free end. The cuff electrode assembly further includes a first arm member and a second arm member each projecting radially outward from the cuff body and spaced from one another along the cuff body. The cuff body can be configured such that a force applied to urge the first and second arm members toward one another defines an open configuration of the cuff body configured to allow the cuff body to be positioned around the target nerve. The cuff electrode assembly further includes an electrode oriented to provide electrical stimuli to the target nerve.

Abstract: A treatment system includes a fluid cooling supply system for chilling and delivering liquid coolant to a patient. The fluid cooling supply system includes a cooling device and a heat exchanger device. The heat exchanger device is biased to the cooling device and is in fluid communication with a treatment device in a patient. The fluid cooling supply system includes at least one biasing mechanism to provide a given biasing force between the heat exchanger device and the cooling device to effectuate and improve heat transfer. The liquid coolant may be circulated through an energy delivery device positioned in an airway of a patient to preserve tissue. The system is controlled to circulate liquid coolant at a given temperature and pressure for a selected amount of time during pulmonary treatment of a patient.

Abstract: The invention describes a cuff electrode assembly and method for implanting that includes a resilient cuff body configured to be disposed about a nerve. The cuff body includes a first end portion and a second end portion. The cuff body can be pre-formed to define a closed configuration having a generally annular cross-sectional shape such that, in the closed configuration, the cuff body extends helically with the first and second end portions overlapping on different planes. The cuff electrode assembly includes a first arm member and a second arm member, each projecting radially outward from the cuff body and spaced from one another along the cuff body. The cuff body can be configured such that force applied to urge the first and second arm members toward one another causes relative deflection of the first end portion and the second end portion to define an open configuration of the cuff body.

Abstract: The invention describes a cuff electrode assembly that includes a resilient cuff body configured to be disposed about a nerve. The cuff body includes a first end portion and a second end portion. The cuff body can be pre-formed to define a closed configuration having a generally annular cross-sectional shape such that, in the closed configuration, the cuff body extends helically with the first and second end portions overlapping on different planes. The cuff electrode assembly includes a first arm member and a second arm member, each projecting radially outward from the cuff body and spaced from one another along the cuff body. The cuff body can be configured such that force applied to urge the first and second arm members toward one another causes relative deflection of the first end portion and the second end portion to define an open configuration of the cuff body.

Abstract: The present invention provides a cuff electrode assembly for implantation on a target nerve. The cuff electrode assembly can include a resilient cuff body configured to be disposed about the target nerve. The cuff body includes a first end portion having a first free end, and a second end portion having a second free end. The cuff electrode assembly further includes a first arm member and a second arm member each projecting radially outward from the cuff body and spaced from one another along the cuff body. The cuff body can be configured such that a force applied to urge the first and second arm members toward one another defines an open configuration of the cuff body configured to allow the cuff body to be positioned around the target nerve. The cuff electrode assembly further includes an electrode oriented to provide electrical stimuli to the target nerve.

Abstract: An implantable cardiac rhythm management (CRM) system for directing stimulation energy toward a target tissue and away from unwanted tissues for providing an appropriate stimulation is provided by the present invention. The implantable cardiac rhythm management (CRM) system includes an implantable lead. The implantable lead includes a lead body and an electrically insulating member. The lead body includes at least one electrode extending substantially around the lead body. The electrically insulating member defines at least one window. At least one insulating member includes a protruding portion configured to urge at least one electrode toward the target tissue.