Patents by Inventor Kyohei Koshimoto

Kyohei Koshimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF PRODUCING HAIRPIN SINGLE-STRANDED RNA MOLECULES
    Publication number: 20240110186
    Abstract: A method produces a hairpin single-stranded RNA molecule capable of inhibiting expression of a target gene, including the step of reacting a first single-stranded oligo-RNA molecule represented by formula (I) with a second single-stranded oligo-RNA molecule represented by formula (II) in a mixed solvent including a buffer solution and a hydrophilic organic solvent in the presence of a dehydration condensation agent: 5?-Xc-Lx1 . . . (I) and Lx2-X—Y-Ly-Yc-3? . . . (II), wherein the dehydration condensation agent is selected from the group consisting of a triazine-based dehydration condensation agent, a uronium-based dehydration condensation agent including an N-hydroxy nitrogen-containing aromatic ring structure, a carbodiimide-based dehydration condensation agent, a 2-halopyridinium-based dehydration condensation agent, and a formamidinium-based dehydration condensation agent.
    Type: Application
    Filed: September 1, 2023
    Publication date: April 4, 2024
    Inventors: Kyohei Koshimoto, Katsuhiko Iseki, Hideaki Inada, Tatsuya Fujita, Keiichi Okimura, Munetaka Kunishima, Tadaaki Ohgi, Eriko Aoki
  • Method of producing hairpin single-stranded RNA molecules
    Patent number: 11891602
    Abstract: A method produces a hairpin single-stranded RNA molecule capable of inhibiting expression of a target gene, including the step of reacting a first single-stranded oligo-RNA molecule represented by formula (I) with a second single-stranded oligo-RNA molecule represented by formula (II) in a mixed solvent including a buffer solution and a hydrophilic organic solvent in the presence of a dehydration condensation agent: 5?-Xc-Lx1 (I) and Lx2-X—Y-Ly-Yc-3? (II), wherein the dehydration condensation agent is selected from the group consisting of a triazine-based dehydration condensation agent, a uronium-based dehydration condensation agent including an N-hydroxy nitrogen-containing aromatic ring structure, a carbodiimide-based dehydration condensation agent, a 2-halopyridinium-based dehydration condensation agent, and a formamidinium-based dehydration condensation agent.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: February 6, 2024
    Assignee: Toray Industries, Inc.
    Inventors: Kyohei Koshimoto, Katsuhiko Iseki, Hideaki Inada, Tatsuya Fujita, Keiichi Okimura, Munetaka Kunishima, Tadaaki Ohgi, Eriko Aoki
  • METHOD OF PRODUCING HAIRPIN SINGLE-STRANDED RNA MOLECULES
    Publication number: 20210317495
    Abstract: A method produces a hairpin single-stranded RNA molecule capable of inhibiting expression of a target gene, including the step of reacting a first single-stranded oligo-RNA molecule represented by formula (I) with a second single-stranded oligo-RNA molecule represented by formula (II) in a mixed solvent including a buffer solution and a hydrophilic organic solvent in the presence of a dehydration condensation agent: 5?-Xc-Lx1 (I) and Lx2-X—Y-Ly-Yc-3? (II), wherein the dehydration condensation agent is selected from the group consisting of a triazine-based dehydration condensation agent, a uronium-based dehydration condensation agent including an N-hydroxy nitrogen-containing aromatic ring structure, a carbodiimide-based dehydration condensation agent, a 2-halopyridinium-based dehydration condensation agent, and a formamidinium-based dehydration condensation agent.
    Type: Application
    Filed: October 2, 2019
    Publication date: October 14, 2021
    Inventors: Kyohei Koshimoto, Katsuhiko Iseki, Hideaki Inada, Tatsuya Fujita, Keiichi Okimura, Munetaka Kunishima, Tadaaki Ohgi, Eriko Aoki