Patents by Inventor Kyohei OCHIAI

Kyohei OCHIAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200324024
    Abstract: The present invention addresses the problem of providing a decellularized tissue having excellent cell adhesion properties. Provided is a decellularized tissue prepared by decellularizing a biological tissue, said decellularized tissue being characterized in that the ratio of endothermic energy amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization is 0.70 or greater when measured by differential scanning calorimetry. The ratio by mass of DNA amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization may be 0.300 or smaller.
    Type: Application
    Filed: June 19, 2020
    Publication date: October 15, 2020
    Inventors: Jun NEGISHI, Ken-ichiro HIWATARI, Kyohei OCHIAI
  • Patent number: 10793603
    Abstract: A polysaccharide derivative has a partial structure represented by Formula (1) below. It is preferable that at least one of the amino acids that constitute X2 in Formula (1) below is a basic amino acid. (In the formula, X1 represents a residue obtained by removing the terminal amino group and the terminal carboxyl group from a neutral amino acid or an ?-aminoalkanoic acid, X2 represents a residue obtained by removing the terminal amino group and the terminal carboxyl group from a membrane-permeable peptide, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, a represents a number of 0 or 1, and b represents a number of from 0 to 50.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: October 6, 2020
    Assignees: JOSHO GAKUEN EDUCATIONAL FOUNDATION, ADEKA CORPORATION
    Inventors: Shinji Sakuma, Kohta Mohri, Ken-ichiro Hiwatari, Kyohei Ochiai
  • Publication number: 20200222589
    Abstract: A method of producing a decellularized transplantation material, wherein the method includes the steps of (a) harvesting a branch-bearing blood vessel from a vertebrate animal (a donor); (b) decellularizing the blood vessel; and (c) adhering, by a protein denaturation treatment, a portion where a branch has been excised to close the vessel. Also, a graft composition consisting of a biocompatible material that contains the decellularized transplantation material.
    Type: Application
    Filed: May 25, 2018
    Publication date: July 16, 2020
    Applicant: ADEKA CORPORATION
    Inventors: Tetsuya HIGAMI, Kenichiro HIWATARI, Yu YAMAGUCHI, Haruki OBARA, Takuya KIMURA, Mitsumasa HOMMA, Kyohei OCHIAI, Keita KINOSHITA, Naoki MORIMOTO
  • Publication number: 20200114044
    Abstract: The present invention addresses the problem of providing a decellularized tissue having excellent cell adhesion properties. Provided is a decellularized tissue prepared by decellularizing a biological tissue, said decellularized tissue being characterized in that the ratio of endothermic energy amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization is 0.70 or greater when measured by differential scanning calorimetry. The ratio by mass of DNA amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization may be 0.300 or smaller.
    Type: Application
    Filed: December 13, 2019
    Publication date: April 16, 2020
    Inventors: Jun NEGISHI, Ken-ichiro HIWATARI, Kyohei OCHIAI
  • Patent number: 10501564
    Abstract: A polymer compound has a group represented by Formula (1) or Formula (2) in a side chain. (In Formula (1), X1 represents a neutral amino acid residue or an ?-aminoalkanoic acid residue, X2 represents a membrane-permeable peptide residue, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, and a represents a number of from 1 to 50.) (In Formula (2), X4 represents a neutral amino acid residue or an ?-aminoalkanoic acid residue, X5 represents a membrane-permeable peptide residue, X6 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a benzyl group, an acyl group having 1 to 6 carbon atoms, an arylsulfonyl group, or a carboxyl group, and b represents a number of from 1 to 50.).
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: December 10, 2019
    Assignees: JOSHO GAKUEN EDUCATIONAL FOUNDATION, ADEKA CORPORATION
    Inventors: Shinji Sakuma, Kohta Mohri, Ken-ichiro Hiwatari, Kyohei Ochiai
  • Publication number: 20180044381
    Abstract: A polysaccharide derivative has a partial structure represented by Formula (1) below. It is preferable that at least one of the amino acids that constitute X2 in Formula (1) below is a basic amino acid. (In the formula, X1 represents a residue obtained by removing the terminal amino group and the terminal carboxyl group from a neutral amino acid or an ?-aminoalkanoic acid, X2 represents a residue obtained by removing the terminal amino group and the terminal carboxyl group from a membrane-permeable peptide, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, a represents a number of 0 or 1, and b represents a number of from 0 to 50.
    Type: Application
    Filed: February 23, 2016
    Publication date: February 15, 2018
    Inventors: Shinji SAKUMA, Kohta MOHRI, Ken-ichiro HIWATARI, Kyohei OCHIAI
  • Publication number: 20180028722
    Abstract: The present invention addresses the problem of providing a decellularized tissue having excellent cell adhesion properties. Provided is a decellularized tissue prepared by decellularizing a biological tissue, said decellularized tissue being characterized in that the ratio of endothermic energy amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization is 0.70 or greater when measured by differential scanning calorimetry. The ratio by mass of DNA amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization may be 0.300 or smaller.
    Type: Application
    Filed: February 19, 2016
    Publication date: February 1, 2018
    Inventors: Jun NEGISHI, Ken-ichiro HIWATARI, Kyohei OCHIAI
  • Publication number: 20180016366
    Abstract: A polymer compound has a group represented by Formula (1) or Formula (2) in a side chain. (In Formula (1), X1 represents a neutral amino acid residue or an ?-aminoalkanoic acid residue, X2 represents a membrane-permeable peptide residue, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, and a represents a number of from 1 to 50.) (In Formula (2), X4 represents a neutral amino acid residue or an ?-aminoalkanoic acid residue, X5 represents a membrane-permeable peptide residue, X6 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a benzyl group, an acyl group having 1 to 6 carbon atoms, an arylsulfonyl group, or a carboxyl group, and b represents a number of from 1 to 50.
    Type: Application
    Filed: February 23, 2016
    Publication date: January 18, 2018
    Inventors: Shinji SAKUMA, Kohta MOHRI, Ken-ichiro HIWATARI, Kyohei OCHIAI