Patents by Inventor Kyoichi Kobashi

Kyoichi Kobashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Examination method of infection with Helicobacter pylori
    Patent number: 6312918
    Abstract: There are described a simple examination method of infection with Helicobacter pylori possibly presenting in a gastric mucosa, and a device therefor. The examination is conducted by collecting gas in gastric cavity, and measuring mainly ammonia and additionally organic amines which are generated due to activities of the bacilli. The measurement is carried out by leading the gas in gastric cavity into oral cavity by vomiting-reflex, and sucking the gas by a metering suction pump through a gas detection tube to read-out a length of color-changed area in the gas detection tube.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: November 6, 2001
    Assignees: Gastec Corporation, Eisai Co., Ltd.
    Inventors: Masaharu Ito, Kunitoshi Matsunobu, Masanori Uono, Susumu Kanemaki, Kyoichi Kobashi
  • Anticoagulant hirudin variants and methods for their production
    Patent number: 5880258
    Abstract: The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.Phe-Glu-A-Ile-Pro-D-Tyr(R) Tyr(R) (I)?In the formula, A represents Glu or Pro, R represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: March 9, 1999
    Assignees: Japan Energy Corporation, Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Ryo Muramatsu, Akiko Sukesada, Satoru Misawa, Eriko Nukui, Koichi Wada, Masaharu Nakano, Tadanori Morikawa, Kyoichi Kobashi
  • Anticoagulant hirudin variants and methods for their production
    Patent number: 5767235
    Abstract: The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.Phe-Glu-A-Ile-Pro-B-Tyr(R)-Tyr(R) (I)?In the formula, A represents Glu or Pro, B represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: June 16, 1998
    Assignees: Nippon Mining Company Limited, Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Eriko Nukui, Koichi Wada, Masaharu Nakano, Tadanori Morikawa, Kyoichi Kobashi, Ryo Muramatsu, Akiko Sukesada, Satoru Misawa
  • Simple examination method of infection with Helicobacter pylori and device therefor
    Patent number: 5719052
    Abstract: There are described a simple examination method of infection with Helicobacter pylori possibly presenting in a gastric mucosa, and a device therefor. The examination is conducted by collecting gas in gastric cavity, and measuring mainly ammonia and additionally organic amines which are generated due to activities of the bacilli. The measurement is carried out by leading the gas in gastric cavity into oral cavity by vomiting-reflex, and sucking the gas by a metering suction pump through a gas detection tube to read-out a length of color-changed area in the gas detection tube.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: February 17, 1998
    Assignee: Gastec Corporation
    Inventors: Masaharu Ito, Kunitoshi Matsunobu, Masanori Uono, Susumu Kanemaki, Kyoichi Kobashi
  • Method of producing acid urease and the use of the urease
    Patent number: 4970153
    Abstract: Lactobacillus fermentum TK 1214 produces an acid urease that is useful in decomposing urea that gives an objectionable taste when present in fermented foods. The urease produced has an optimum activity at a pH of 2.8-4.0 and at a temperature of about 60.degree. C. The fermented foods may be treated with either intact cells or a cell extract of the microorganism, either during fermentation of the foods or after fermentation has been completed.
    Type: Grant
    Filed: February 3, 1988
    Date of Patent: November 13, 1990
    Assignees: Nagase & Co., Ltd., Nagase Biochemicals, Ltd.
    Inventors: Kyoichi Kobashi, Sachiko Takebe, Takefumi Kobayashi, Suehiro Honda, Kiyoshi Kusai, Hideo Mishima
  • Novel hydroxamic acid compounds, method for preparation thereof and medicaments containing such compounds
    Patent number: 4256765
    Abstract: A novel hydroxamic acid compound represented by the general formula:R.sub.1 --CONHCH.sub.2 CONHOHwherein R.sub.1 is an alkyl, cycloalkyl or cycloalkyl alkyl group having from 4 to 11 carbon atoms, and pharmacologically acceptable salt thereof, and a method for the preparation of the above-mentioned compound and salt, and a novel medicament for the treatment of urolithiasis and pyelonephritis, containing the above-mentioned compound or salt as an active ingredient.
    Type: Grant
    Filed: September 18, 1979
    Date of Patent: March 17, 1981
    Assignee: Eisai Co., Ltd.
    Inventors: Keiichi Munakata, Satoru Tanaka, Tamotsu Kanazawa, Masaru Satoh, Jun-ichi Hase, Kyoichi Kobashi